Patents by Inventor Ivan Osorio

Ivan Osorio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12383190
    Abstract: Methods, system and apparatus for identifying an extreme epileptic state/event in a patient are provided. In one aspect, at least two seizure events are identified. At least one inter-seizure interval (ISI) value related to the at least two seizure events are determined. The ISI value is compared to at least one reference value. An occurrence of an extreme seizure event is determined based upon the comparison of the determined ISI value to the at least one reference value. In another aspect, a first seizure event is detected. At least one body index affected by the first seizure event is determined. A second seizure event is detected. An occurrence of an extreme seizure event is determined based at least in part in response to a determination that the second seizure event occurred prior to the body index value returning to a reference value.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: August 12, 2025
    Assignee: FLINT HILLS SCIENTIFIC, LLC
    Inventor: Ivan Osorio
  • Patent number: 12377269
    Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: August 5, 2025
    Assignee: FLINT HILLS SCIENTIFIC, LLC
    Inventor: Ivan Osorio
  • Publication number: 20250194990
    Abstract: We report a method of a method for detecting an epileptic seizure, comprising providing a first body signal reference value; determining a current body signal value from a time series of body signals; comparing the current body signal value and the first reference value; determining a work level of the patient; determining whether the current body signal value comprises an ictal component, based on the work level and the comparing; issuing a detection of an epileptic seizure in response to the determination that the current body signal value comprises the ictal component; and taking at least one further action (e.g. warning, delivering a therapy, etc.), based on the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Application
    Filed: November 14, 2024
    Publication date: June 19, 2025
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 12310740
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: May 27, 2025
    Assignee: FLINT HILLS SCIENTIFIC, LLC.
    Inventors: Ivan Osorio, Mark Frei
  • Publication number: 20250160660
    Abstract: A method, comprising receiving a time series of patient body signal, determining first and second sliding time windows for the time series; applying an autoregression algorithm, comprising: applying an autoregression analysis to each of the first and second windows, yielding autoregression coefficients and a residual variance for each window; estimating a parameter vector for each window based on the autoregression coefficients and residual variances; and determining a difference between the parameter vectors; and determining seizure onset and seizure termination based on the difference between the parameter vectors. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Application
    Filed: January 17, 2025
    Publication date: May 22, 2025
    Applicant: Flint Hills Scientific, L.L.C.
    Inventors: Ivan Osorio, Alexey Lyubushin, Didier Sornette
  • Publication number: 20250152084
    Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
    Type: Application
    Filed: January 16, 2025
    Publication date: May 15, 2025
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 12274880
    Abstract: A method, comprising detecting, in at least a first brain region of a patient, an electrical activity relating to an epileptic activity; determining a first regularity index of said electrical activity; and applying at least one first electrical stimulation to at least one neural target of said patient for treating said epileptic event, in response to said first regularity index being within a first range. A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform the method. A medical device system suitable for use in the method.
    Type: Grant
    Filed: September 24, 2023
    Date of Patent: April 15, 2025
    Assignee: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20250114602
    Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
    Type: Application
    Filed: September 24, 2024
    Publication date: April 10, 2025
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 12226193
    Abstract: A method, comprising receiving a time series of patient body signal, determining first and second sliding time windows for the time series; applying an autoregression algorithm, comprising: applying an autoregression analysis to each of the first and second windows, yielding autoregression coefficients and a residual variance for each window; estimating a parameter vector for each window based on the autoregression coefficients and residual variances; and determining a difference between the parameter vectors; and determining seizure onset and seizure termination based on the difference between the parameter vectors. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Grant
    Filed: May 26, 2023
    Date of Patent: February 18, 2025
    Assignee: Flint Hills Scientific, L.L.C.
    Inventors: Ivan Osorio, Alexey Lyubushin, Didier Sornette
  • Patent number: 12201437
    Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
    Type: Grant
    Filed: December 11, 2021
    Date of Patent: January 21, 2025
    Assignee: FLINT HILLS SCIENTIFIC, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 12178594
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: December 31, 2024
    Assignee: Flint Hills Scientific, LLC
    Inventors: Ivan Osorio, Mark Frei
  • Publication number: 20240423531
    Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
    Type: Application
    Filed: September 6, 2024
    Publication date: December 26, 2024
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20240423559
    Abstract: A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively.
    Type: Application
    Filed: August 29, 2024
    Publication date: December 26, 2024
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20240399151
    Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
    Type: Application
    Filed: June 11, 2024
    Publication date: December 5, 2024
    Inventor: Ivan Osorio
  • Patent number: 12144640
    Abstract: We report a method of a method for detecting an epileptic seizure, comprising providing a first body signal reference value; determining a current body signal value from a time series of body signals; comparing the current body signal value and the first reference value; determining a work level of the patient; determining whether the current body signal value comprises an ictal component, based on the work level and the comparing; issuing a detection of an epileptic seizure in response to the determination that the current body signal value comprises the ictal component; and taking at least one further action (e.g. warning, delivering a therapy, etc.), based on the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Grant
    Filed: April 27, 2021
    Date of Patent: November 19, 2024
    Assignee: Flint Hills Scientivic, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 12121727
    Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
    Type: Grant
    Filed: April 11, 2023
    Date of Patent: October 22, 2024
    Assignee: Flint Hills Scientific, LLC
    Inventor: Ivan Osorio
  • Publication number: 20240341670
    Abstract: We report a method comprising receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering the first biological signal or feature thereof; receiving a second indication to stop gathering the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering the first biological signal or feature thereof. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Application
    Filed: June 24, 2024
    Publication date: October 17, 2024
    Inventor: Ivan Osorio
  • Patent number: 12082939
    Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
    Type: Grant
    Filed: June 3, 2022
    Date of Patent: September 10, 2024
    Assignee: Flint Hills Scientific, LLC
    Inventor: Ivan Osorio
  • Patent number: 12076170
    Abstract: A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively.
    Type: Grant
    Filed: July 21, 2022
    Date of Patent: September 3, 2024
    Assignee: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 12023169
    Abstract: We report a method comprising receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering the first biological signal or feature thereof; receiving a second indication to stop gathering the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering the first biological signal or feature thereof. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: July 2, 2024
    Assignee: FLINT HILLS SCIENTIFIC, L.L.C.
    Inventor: Ivan Osorio