Abstract: Colorimetry is used to detect amplification reaction products. A sample is contacted with a reaction mix under conditions such that an amplification reaction occurs and produces an amplification reaction product if the sample contains a target nucleic acid template molecule. The reaction mix includes an enzyme for catalyzing the amplification reaction, and at least one halochromic agent. If the target nucleic acid template molecule is present, the amplification reaction changes the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating the presence of the target nucleic acid. If the target nucleic acid template molecule is not present, the amplification reaction does not generate an adequate number of protons to sufficiently change the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating that the amplification reaction product has not been produced.

Abstract: Among other things, the present disclosure provides various agents. In some embodiments, provided agents can bind to beta-catenin. In some embodiments, the present disclosure provides technologies for modulating beta-catenin functions. In some embodiments, the present disclosure provides technologies for preventing and/or treating conditions, disorders or diseases associated with beta-catenin. In some embodiments, the present disclosure provides designed amino acids which can provide improved properties and/or activities. In some embodiments, the present disclosure provides agents comprising such amino acids.

Abstract: A diagnostic system performs disease diagnostic tests using at least an optical property modifying device and a mobile device. A user provides a biological sample from a patient to the optical property modifying device that reacts with a reagent in one or more reaction chambers of the device. The user captures one or more images of the one or more reaction chambers using an optical sensor of the mobile device. The diagnostic system can determine a quality level of the images based on factors such as skew, scale, focusing, shadowing, or white-balancing. Based on an analysis of the captured image, the diagnostic system can determine a test result of a disease diagnostic test for the patient. The diagnostic system may communicate the test result, as well as instructions for the disease diagnostic test, to the user via the mobile device.

Abstract: A cross reality system enables any of multiple devices to efficiently access previously stored maps. Both stored maps and tracking maps used by portable devices may have any of multiple types of location metadata associated with them. The location metadata may be used to select a set of candidate maps for operations, such as localization or map merge, that involve finding a match between a location defined by location information from a portable device and any of a number of previously stored maps. The types of location metadata may prioritized for use in selecting the subset. To aid in selection of candidate maps, a universe of stored maps may be indexed based on geo-location information. A cross reality platform may update that index as it interacts with devices that supply geo-location information in connection with location information and may propagate that geo-location information to devices that do not supply it.

Abstract: A bottle, having an antimicrobial property is provided. The bottle has one or more components including a body, a cap, a seal, and a locking ring. One or more of the components of the bottle are treated with an antimicrobial agent or comprise an antimicrobial agent. The antimicrobial is a silver based antimicrobial, a silver-glass antimicrobial, or other antimicrobial agent.

Abstract: Aspects described herein relate to securely performing cross-boundary backup operations. A service of a computing resource service provider may enable backup operations between a source account and a destination account of an organization based at least in part on a security policy allowing such operations.

Abstract: A cross reality system enables any of multiple devices to efficiently access previously stored maps. Both stored maps and tracking maps used by portable devices may have any of multiple types of location metadata associated with them. The location metadata may be used to select a set of candidate maps for operations, such as localization or map merge, that involve finding a match between a location defined by location information from a portable device and any of a number of previously stored maps. The types of location metadata may prioritized for use in selecting the subset. To aid in selection of candidate maps, a universe of stored maps may be indexed based on geo-location information. A cross reality platform may update that index as it interacts with devices that supply geo-location information in connection with location information and may propagate that geo-location information to devices that do not supply it.

Abstract: A system form localizing an electronic device with dynamic buffering identifies, from the buffer, a first set of features that is extracted from a first image captured by the electronic device and receives, at the system, a second set of features that is extracted from a second image captured by the electronic device. The system further determines a first characteristic for the first set of features and a second characteristic for the second set of features and determines whether a triggering condition for dynamically changing a size of the buffer is satisfied based at least in part upon the first characteristic for the first set of features and the second characteristic for the second set of features.

Abstract: A system form localizing an electronic device with dynamic buffering identifies, from the buffer, a first set of features that is extracted from a first image captured by the electronic device and receives, at the system, a second set of features that is extracted from a second image captured by the electronic device. The system further determines a first characteristic for the first set of features and a second characteristic for the second set of features and determines whether a triggering condition for dynamically changing a size of the buffer is satisfied based at least in part upon the first characteristic for the first set of features and the second characteristic for the second set of features.

Abstract: A method includes capturing an image using a content capture device with an initial image setting. The image includes a plurality of pixel groups, and a pixel group can have one or more pixels. A plurality of edge pixel groups is identified and then classified into two subsets. A first subset of saturated edge pixel groups includes edge pixel groups that have at least one neighboring pixel group with an image intensity exceeding a saturated intensity value. A second subset of non-saturated edge pixel groups includes edge pixel groups that have no neighboring pixel groups with an image intensity exceeding a saturated intensity value. An adjustment value to the image setting is determined based on a total number of saturated edge pixel groups and a total number of non-saturated edge pixel groups. An updated image is captured with an updated image setting based on the adjustment value.

Abstract: An augmented reality viewing system is described. A local coordinate frame of local content is transformed to a world coordinate frame. A further transformation is made to a head coordinate frame and a further transformation is made to a camera coordinate frame that includes all pupil positions of an eye. One or more users may interact in separate sessions with a viewing system. If a canonical map is available, the earlier map is downloaded onto a viewing device of a user. The viewing device then generates another map and localizes the subsequent map to the canonical map.

Abstract: A cross reality system enables any of multiple types of devices to efficiently and accurately access previously stored maps and render virtual content specified in relation to those maps. The cross reality system may include a cloud-based localization service that responds to requests from devices to localize with respect to a stored map. Devices of any type, with native hardware and software configured for augmented reality operations may be configured to work with the cross reality system by incorporating components that interface between the native AR framework of the device and the cloud-based localization service. These components may present position information about the device in a format recognized by the localization service. Additionally, these components may filter or otherwise process perception data provided by the native AR framework to increase the accuracy of localization.

Abstract: A cross reality system that provides an immersive user experience by storing persistent spatial information about the physical world that one or multiple user devices can access to determine position within the physical world and that applications can access to specify the position of virtual objects within the physical world. Persistent spatial information enables users to have a shared virtual, as well as physical, experience when interacting with the cross reality system. Further, persistent spatial information may be used in maps of the physical world, enabling one or multiple devices to access and localize into previously stored maps, reducing the need to map a physical space before using the cross reality system in it. Persistent spatial information may be stored as persistent coordinate frames, which may include a transformation relative to a reference orientation and information derived from images in a location corresponding to the persistent coordinate frame.

Abstract: A cross reality system enables any of multiple types of devices to efficiently and accurately access previously stored maps and render virtual content specified in relation to those maps. The cross reality system may include a cloud-based localization service that responds to requests from devices to localize with respect to a stored map. Devices of any type, with native hardware and software configured for augmented reality operations may be configured to work with the cross reality system by incorporating components that interface between the native AR framework of the device and the cloud-based localization service. These components may present position information about the device in a format recognized by the localization service. Additionally, these components may filter or otherwise process perception data provided by the native AR framework to increase the accuracy of localization.

Abstract: A cross reality system that provides an immersive user experience by storing persistent spatial information about the physical world that one or multiple user devices can access to determine position within the physical world and that applications can access to specify the position of virtual objects within the physical world. Persistent spatial information enables users to have a shared virtual, as well as physical, experience when interacting with the cross reality system. Further, persistent spatial information may be used in maps of the physical world, enabling one or multiple devices to access and localize into previously stored maps, reducing the need to map a physical space before using the cross reality system in it. Persistent spatial information may be stored as persistent coordinate frames, which may include a transformation relative to a reference orientation and information derived from images in a location corresponding to the persistent coordinate frame.

Abstract: A dental instrument is configured to reduce user discomfort and increase control over the surgical edge of the instrument. The invention further discloses a dental instrument having a replaceable blade.

Abstract: A system form localizing an electronic device with dynamic buffering identifies, from the buffer, a first set of features that is extracted from a first image captured by the electronic device and receives, at the system, a second set of features that is extracted from a second image captured by the electronic device. The system further determines a first characteristic for the first set of features and a second characteristic for the second set of features and determines whether a triggering condition for dynamically changing a size of the buffer is satisfied based at least in part upon the first characteristic for the first set of features and the second characteristic for the second set of features.

Abstract: A cross reality system enables any of multiple devices to efficiently access previously stored maps. Both stored maps and tracking maps used by portable devices may have any of multiple types of location metadata associated with them. The location metadata may be used to select a set of candidate maps for operations, such as localization or map merge, that involve finding a match between a location defined by location information from a portable device and any of a number of previously stored maps. The types of location metadata may prioritized for use in selecting the subset. To aid in selection of candidate maps, a universe of stored maps may be indexed based on geo-location information. A cross reality platform may update that index as it interacts with devices that supply geo-location information in connection with location information and may propagate that geo-location information to devices that do not supply it.

Abstract: An augmented reality viewing system is described. A local coordinate frame of local content is transformed to a world coordinate frame. A further transformation is made to a head coordinate frame and a further transformation is made to a camera coordinate frame that includes all pupil positions of an eye. One or more users may interact in separate sessions with a viewing system. If a canonical map is available, the earlier map is downloaded onto a viewing device of a user. The viewing device then generates another map and localizes the subsequent map to the canonical map.

Abstract: A method includes capturing an image using a content capture device with an initial image setting. The image includes a plurality of pixel groups, and a pixel group can have one or more pixels. A plurality of edge pixel groups is identified and then classified into two subsets. A first subset of saturated edge pixel groups includes edge pixel groups that have at least one neighboring pixel group with an image intensity exceeding a saturated intensity value. A second subset of non-saturated edge pixel groups includes edge pixel groups that have no neighboring pixel groups with an image intensity exceeding a saturated intensity value. An adjustment value to the image setting is determined based on a total number of saturated edge pixel groups and a total number of non-saturated edge pixel groups. An updated image is captured with an updated image setting based on the adjustment value.