Abstract: Described are methods and systems for identifying a target for therapy and treating a subject that exhibits a disease gene expression signature, comprising identifying and administering a therapy determined to revert a disease gene expression signature in a subject suffering from a disease, disorder, or condition toward a non-diseased expression signature (e.g., disease gene expression signature of a non-diseased subject).

Abstract: Network architectures and methods including addressing and dynamic network topology construction schemes that guarantee maximally efficient and scalable routing are disclosed herein. The network architectures and methods introduce a new approach to network design. The network architectures and methods include an addressing scheme based on geographic position of network nodes, and a network topology construction scheme based on the addressing scheme and that can reproduce properties of the existing Internet topology. A routing algorithm for the network architecture is shown to be maximally scalable and efficient. According to an example embodiment, a network includes a plurality of nodes, where each node has a network address based on a latitude of a location of the node, a longitude of the location of the node, and a centrality of the location of the node.

Abstract: Network architectures and methods including addressing and dynamic network topology construction schemes that guarantee maximally efficient and scalable routing are disclosed herein. The network architectures and methods introduce a new approach to network design. The network architectures and methods include an addressing scheme based on geographic position of network nodes, and a network topology construction scheme based on the addressing scheme and that can reproduce properties of the existing Internet topology. A routing algorithm for the network architecture is shown to be maximally scalable and efficient. According to an example embodiment, a network includes a plurality of nodes, where each node has a network address based on a latitude of a location of the node, a longitude of the location of the node, and a centrality of the location of the node.