Patents by Inventor Ivana Celic

Ivana Celic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sample processing device
    Patent number: 9242245
    Abstract: A floating chamber set may include a plurality of containers coupled to a frame such that each container translates vertically within a limited vertical range independent of the other containers. Each container may be perforated to allow liquid penetration.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: January 26, 2016
    Assignee: The Johns Hopkins University
    Inventors: Alex Leo Kolodkin, Terry Harrison Shelley, Shih-Hsiu Wang, Ivana Celic
  • Sample Processing Device
    Publication number: 20120208207
    Abstract: A floating chamber set may include a plurality of containers coupled to a frame such that each container translates vertically within a limited vertical range independent of the other containers. Each container may be perforated to allow liquid penetration.
    Type: Application
    Filed: September 21, 2010
    Publication date: August 16, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Alex Leo Kolodkin, Terry Harrison Shelley, Shih-Hsiu Wang, Ivana Celic
  • Sir2 products and activities
    Patent number: 7741295
    Abstract: A novel compound, 2?/3?-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2? and 3? regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2?-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated peptides and NAD+. Analogs of 2?/3?-O-acetyl-ADP-ribose are also provided. Additionally, methods of preparing 2?/3?-O-acetyl-ADP-ribose, methods of determining whether a test compound is an inhibitor of a Sir2 enzyme, methods of detecting Sir2 activity in a composition, methods of deacetylating an acetylated peptide, and methods of inhibiting the deacetylation of an acetylated peptide are provided. Prodrugs of 2?/3?-O-acetyl-ADP-ribose are also provided.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: June 22, 2010
    Assignees: Albert Einstein College of Medicine of Yeshiva University, The Johns Hopkins University
    Inventors: Vern L. Schramm, Jef D. Boeke, Anthony Sauvé, Ivana Celic
  • Sir2 products and activities
    Publication number: 20090068695
    Abstract: A novel compound, 2?/3?-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2? and 3? regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2?-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated peptides and NAD+. Analogs of 2?/3?-O-acetyl-ADP-ribose are also provided. Additionally, methods of preparing 2?/3?-O-acetyl-ADP-ribose, methods of determining whether a test compound is an inhibitor of a Sir2 enzyme, methods of detecting Sir2 activity in a composition, methods of deacetylating an acetylated peptide, and methods of inhibiting the deacetylation of an acetylated peptide are provided. Prodrugs of 2?/3?-O-acetyl-ADP-ribose are also provided.
    Type: Application
    Filed: September 5, 2008
    Publication date: March 12, 2009
    Inventors: Vern L. Schramm, Jef D. Boeke, Anthony Sauve, Ivana Celic
  • Sir2 products and activities
    Patent number: 7432246
    Abstract: A novel compound, 2?/3?-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2? and 3? regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2?-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated peptides and NAD+. Analogs of 2?/3?-O-acetyl-ADP-ribose are also provided. Additionally, methods of preparing 2?/3?-O-acetyl-ADP-ribose, methods of determining whether a test compound is an inhibitor of a Sir2 enzyme, methods of detecting Sir2 activity in a composition, methods of deacetylating an acetylated peptide, and methods of inhibiting the deacetylation of an acetylated peptide are provided. Prodrugs of 2?/3?-O-acetyl-ADP-ribose are also provided.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: October 7, 2008
    Assignees: Albert Einstein College of Medicine of Yeshiva University, The Johns Hopkins University
    Inventors: Vern L. Schramm, Jef D. Boeke, Anthony Sauvé, Ivana Celic
  • Sir2 products and activities
    Publication number: 20060058520
    Abstract: A novel compound, 2?/3?-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2? and 3? regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2?-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated peptides and NAD+. Analogs of 2?/3?-O-acetyl-ADP-ribose are also provided. Additionally, methods of preparing 2?/3?-O-acetyl-ADP-ribose, methods of determining whether a test compound is an inhibitor of a Sir2 enzyme, methods of detecting Sir2 activity in a composition, methods of deacetylating an acetylated peptide, and methods of inhibiting the deacetylation of an acetylated peptide are provided. Prodrugs of 2?/3?-O-acetyl-ADP-ribose are also provided.
    Type: Application
    Filed: October 12, 2005
    Publication date: March 16, 2006
    Inventors: Vern Schramm, Jef Boeke, Anthony Sauve, Ivana Celic
  • Sir2 products and activities
    Patent number: 6987091
    Abstract: A novel compound, 2?/3?-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2? and 3? regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2?-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated peptides and NAD+. Analogs of 2?/3?-O-acetyl-ADP-ribose are also provided. Additionally, methods of preparing 2?/3?-O-acetyl-ADP-ribose, methods of determining whether a test compound is an inhibitor of a Sir2 enzyme, methods of detecting Sir2 activity in a composition, methods of deacetylating an acetylated peptide, and methods of inhibiting the deacetylation of an acetylated peptide are provided. Prodrugs of 2?/3?-O-acetyl-ADP-ribose are also provided.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: January 17, 2006
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Vern L. Schramm, Jef D. Boeke, Anthony Sauvé, Ivana Celic
  • Sir2 products and activities
    Publication number: 20030149261
    Abstract: A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated peptides and NAD+. Analogs of 2′/3′-O-acetyl-ADP-ribose are also provided. Additionally, methods of preparing 2′/3′-O-acetyl-ADP-ribose, methods of determining whether a test compound is an inhibitor of a Sir2 enzyme, methods of detecting Sir2 activity in a composition, methods of deacetylating an acetylated peptide, and methods of inhibiting the deacetylation of an acetylated peptide are provided. Prodrugs of 2′/3′-O-acetyl-ADP-ribose are also provided.
    Type: Application
    Filed: November 21, 2002
    Publication date: August 7, 2003
    Inventors: Vern L. Schramm, Jef D. Boeke, Anthony Sauve, Ivana Celic