Patents by Inventor Ivana TRAPANI

Ivana TRAPANI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VECTOR SYSTEM
    Publication number: 20220389450
    Abstract: A vector system for expressing a transgene in a cell, the vector system comprising a first vector and a second vector, wherein: (a) the first vector comprises in a 5? to 3? direction: a promoter; an intron; a 5? end portion of the transgene coding sequence (CDS); a splice donor sequence; and a first recombinogenic region; (b) the second vector comprises in a 5? to 3? direction: a second recombinogenic region; a splice acceptor sequence; and a 3? end portion of the transgene CDS; wherein the 5? end portion and the 3? end portion together constitute the transgene CDS, and wherein the intron is not capable of homologous recombination with the splice donor sequence to excise the 5? end portion of the transgene CDS.
    Type: Application
    Filed: May 12, 2022
    Publication date: December 8, 2022
    Inventors: Alberto AURICCHIO, Fabio DELL'AQUILA, Ivana TRAPANI, Rita FERLA
  • MULTIPLE VECTOR SYSTEM AND USES THEREOF
    Publication number: 20220002749
    Abstract: The present invention relates to constructs, vectors, relative host cells and pharmaceutical compositions which allow an effective gene therapy, in particular of genes larger than 5 Kb.
    Type: Application
    Filed: March 15, 2021
    Publication date: January 6, 2022
    Inventors: Pasqualina Colella, Alberto Auricchio, Ivana Trapani
  • INTEIN PROTEINS AND USES THEREOF
    Publication number: 20210371878
    Abstract: The present invention relates to constructs, vectors, relative host cells and pharmaceutical compositions which allow an effective gene therapy, in particular of genes larger than 5 Kb.
    Type: Application
    Filed: October 15, 2019
    Publication date: December 2, 2021
    Inventors: Alberto AURICCHIO, Ivana TRAPANI, Patrizia TORNABENE
  • TREATMENT OF BONE GROWTH DISORDERS
    Publication number: 20200230207
    Abstract: The present invention relates to an activator of beclin 1-Vps 34 complex for use in the treatment and/or prevention of a bone growth disorder. The activator may be a polypeptide, a polynucleotide, a vector, a host cell or a small molecule. In particular the activator may be a Beclin 1 peptide or a fragment or a derivative thereof, a mTORC1 inhibitor or a BH3 mimetic. The present invention also relates to pharmaceutical composition comprising said activator.
    Type: Application
    Filed: September 28, 2016
    Publication date: July 23, 2020
    Inventors: Carmine SETTEMBRE, Laura CINQUE, Rosa BARTOLOMEO, Alberto AURICCHIO, Ivana TRAPANI, Elisabetta TORIELLO
  • Effective delivery of large genes by dual AAV vectors
    Patent number: 10494645
    Abstract: The present invention relates to constructs, vectors, relative host cells and pharmaceutical compositions which allow an effective gene therapy, in particular of genes larger than 5 Kb.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: December 3, 2019
    Assignee: FONDAZIONE TELETHON
    Inventors: Alberto Auricchio, Pasqualina Colella, Ivana Trapani
  • MULTIPLE VECTOR SYSTEM AND USES THEREOF
    Publication number: 20180327779
    Abstract: The present invention relates to constructs, vectors, relative host cells and pharmaceutical compositions which allow an effective gene therapy, in particular of genes larger than 5 Kb.
    Type: Application
    Filed: March 3, 2016
    Publication date: November 15, 2018
    Inventors: Pasqualina Colella, Alberto Auricchio, Ivana Trapani
  • EFFECTIVE DELIVERY OF LARGE GENES BY DUAL AAV VECTORS
    Publication number: 20160076054
    Abstract: The present invention relates to constructs, vectors, relative host cells and pharmaceutical compositions which allow an effective gene therapy, in particular of genes larger than 5 Kb.
    Type: Application
    Filed: April 18, 2014
    Publication date: March 17, 2016
    Inventors: Alberto AURICCHIO, Pasqualina COLELLA, Ivana TRAPANI