Patents by Inventor Ivar M. McDonald

Ivar M. McDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS
    Publication number: 20200109140
    Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK?) and diacylglycerol kinase zeta (DGK?), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
    Type: Application
    Filed: June 26, 2019
    Publication date: April 9, 2020
    Inventors: Upender VELAPARTHI, Louis S. Chupak, Chetan Padmakar Darne, Min Ding, Robert G. Gentles, Yazhong Huang, Manjunatha Narayana Rao Kamble, Scott W. Martin, Raju Mannoori, Ivar M. McDonald, Richard E. Olson, Hasibur Rahaman, Prasada Rao Jalagam, Saumya Roy, Gopikishan Tonukunuru, Sivasudar Velaiah, Jayakumar Sankara Warrier, Xiaofan Zheng, John S. Tokarski, Bireshwar Dasgupta, Kotha Rathnakar Reddy, Thiruvenkadam Raja
  • ANTIPROLIFERATIVE COMPOUNDS AND CONJUGATES MADE THEREFROM
    Publication number: 20190358339
    Abstract: A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.
    Type: Application
    Filed: August 6, 2019
    Publication date: November 28, 2019
    Inventors: Ivar M. McDonald, Prasanna Sivaprakasam, Christiana I. Iwuagwu, Kevin M. Peese, Heng Cheng, Naidu S. Chowdari, Sanjeev Gangwar
  • NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS
    Publication number: 20190322694
    Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.
    Type: Application
    Filed: April 12, 2019
    Publication date: October 24, 2019
    Inventors: Michael Anthony SCHMIDT, Bin ZHENG, Kyle KNOUSE, Justine deGRUYTER, Martin D. EASTGATE, Phil BARAN, William R. EWING, Richard E. OLSON, Ivar M. McDONALD
  • CAMK2D ANTISENSE OLIGONUCLEOTIDES AND USES THEREOF
    Publication number: 20190275148
    Abstract: The present disclosure relates to antisense oligonucleotides, which target CAMK2D mRNA in a cell, leading to reduced expression of CAMK2D protein. Reduction of CAMK2D protein expression is beneficial for the treatment of certain medical disorders, e.g., cardiovascular-related diseases or disorders.
    Type: Application
    Filed: February 21, 2019
    Publication date: September 12, 2019
    Inventors: Richard E. Olson, Brian R. Anderson, Peter Hagedorn, Marianne Lerbech Jensen, Ivar M. McDonald, Stephen E. Mercer
  • Antiproliferative compounds and conjugates made therefrom
    Patent number: 10398783
    Abstract: A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: September 3, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ivar M. McDonald, Prasanna Sivaprakasam, Christiana I. Iwuagwu, Kevin M. Peese, Heng Cheng, Naidu S. Chowdari, Sanjeev Gangwar
  • Benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 10112975
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: October 30, 2018
    Assignee: Briston-Myers Squibb Company
    Inventors: Yong Zhang, Ivar M. McDonald, Naidu S. Chowdari, Tram N. Huynh, Robert M. Borzilleri, Sanjeev Gangwar
  • ANTIPROLIFERATIVE COMPOUNDS AND CONJUGATES MADE THEREFROM
    Publication number: 20180110873
    Abstract: A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.
    Type: Application
    Filed: October 20, 2017
    Publication date: April 26, 2018
    Inventors: Ivar M. MCDONALD, Prasanna SIVAPRAKASAM, Christiana I. IWUAGWU, Kevin M. Peese, Heng CHENG, Naidu S. CHOWDARI, Sanjeev GANGWAR
  • BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20180079781
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: October 17, 2017
    Publication date: March 22, 2018
    Inventors: Yong ZHANG, Ivar M. MCDONALD, Naidu S. CHOWDARI, Tram N. HUYNH, Robert M. BORZILLERI, Sanjeev GANGWAR
  • HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20180037581
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: October 17, 2017
    Publication date: February 8, 2018
    Inventors: Ivar M. MCDONALD, Naidu S. CHOWDARI, Walter Lewis JOHNSON, Yong ZHANG, Robert M. BORZILLERI, Sanjeev GANGWAR
  • Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 9822112
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: November 21, 2017
    Assignee: Bristol-Meyers Squibb Company
    Inventors: Ivar M. McDonald, Naidu S. Chowdari, Walter Lewis Johnson, Yong Zhang, Robert M. Borzilleri, Sanjeev Gangwar
  • Benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 9822144
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: November 21, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong Zhang, Ivar M. McDonald, Naidu S. Chowdari, Tram N. Huynh, Robert M. Borzilleri, Sanjeev Gangwar
  • Tricyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands
    Patent number: 9796713
    Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic ?7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: October 24, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ivar M. McDonald, Richard E. Olson, Robert A. Mate
  • BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20170233436
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: May 5, 2017
    Publication date: August 17, 2017
    Inventors: Yong ZHANG, Ivar M. MCDONALD, Naidu S. CHOWDARI, Tram N. HUYNH, Robert M. BORZILLERI, Sanjeev GANGWAR
  • HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20170233392
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: May 5, 2017
    Publication date: August 17, 2017
    Inventors: Ivar M. MCDONALD, Naidu S. Chowdari, Walter Lewis Johnson, Yong Zhang, Robert M. Borzilleri, Sanjeev Gangwar
  • Tricyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands
    Patent number: 9708323
    Abstract: The disclosure provides compounds of formula I including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: July 18, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ivar M. McDonald, F. Christopher Zusi, Richard E. Olson
  • Benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 9676794
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: June 13, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong Zhang, Ivar M. McDonald, Naidu S. Chowdari, Tram N. Huynh, Robert M. Borzilleri, Sanjeev Gangwar
  • Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 9676775
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: June 13, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ivar M. McDonald, Naidu S. Chowdari, Walter Lewis Johnson, Yong Zhang, Robert M. Borzilleri, Sanjeev Gangwar
  • TRICYCLIC COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
    Publication number: 20170137425
    Abstract: The disclosure provides compounds of formula I including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
    Type: Application
    Filed: June 5, 2015
    Publication date: May 18, 2017
    Inventors: Ivar M. MCDONALD, F. Christopher ZUSI, Richard E. OLSON
  • TRICYCLIC COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
    Publication number: 20170129892
    Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic ?7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
    Type: Application
    Filed: June 5, 2015
    Publication date: May 11, 2017
    Inventors: Ivar M. MCDONALD, Richard E. OLSON, Robert A. MATE
  • BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20170073357
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: November 15, 2016
    Publication date: March 16, 2017
    Inventors: Yong ZHANG, Ivar M. MCDONALD, Naidu S. CHOWDARI, Tram N. HUYNH, Robert M. BORZILLERI, Sanjeev GANGWAR