Patents by Inventor Ivars Kalvins

Ivars Kalvins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210205384
    Abstract: Provided herein is the use of an ECHO-7 class oncolytic virus for the treatment of uveal melanoma and compositions comprising the ECHO-7 virus and pharmaceutically acceptable carrier for the treatment of uveal melanoma.
    Type: Application
    Filed: May 23, 2019
    Publication date: July 8, 2021
    Applicant: DITESAN LTD.
    Inventors: Dite Venskus, Ivars Kalvins, Peteris Alberts, Karlis Urbans, Jurgis Auzins
  • Patent number: 10561681
    Abstract: The present invention relates to a novel cancer metastasis preventing and curing selenopheno[h]chromene derivatives, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment and/or prevention of primary cancer and its metastasis by administration of such substances.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: February 18, 2020
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Pavels Arsenjans, Jelena Vasiljeva, Ilona Domracheva, Irina Shestakova, Ivars Kalvins
  • Patent number: 10435672
    Abstract: In a method for manufacturing a modified enterovirus of ECHO 7 type by modification of native ECHO 7 virus, isolated by a known method from human feces and identified by genome sequence, the modification is performed initially conducting the virus adaptation in cancer cells, attenuated by anti-cancer agent dacarbazine, further passaging the modified virus in human embryonal fibroblast culture, followed by propagation in human melanoma cells and further passaging in human embryonal fibroblast culture, that was treated by ribavirin, isolation and purification by known method. The modified virus is suitable for treating various tumors.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: October 8, 2019
    Assignee: DITESAN LTD.
    Inventors: Dite Venskus, Ivars Kalvins, Dace Pjanova, Ramona Petrovska, Jurgis Auzins
  • Publication number: 20190298758
    Abstract: The present invention relates to a novel cancer metastasis preventing and curing selenopheno[h]chromene derivatives, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment and/or prevention of primary cancer and its metastasis by administration of such substances.
    Type: Application
    Filed: July 21, 2016
    Publication date: October 3, 2019
    Inventors: Pavels Arsenjans, Jelena Vasiljeva, Ilona Domracheva, Irina Shestakova, Ivars Kalvins
  • Patent number: 10351534
    Abstract: Salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: July 16, 2019
    Assignee: JSC GRINDEKS
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Ilmars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Reinis Vilskersts, Solveiga Grinberga
  • Publication number: 20190144833
    Abstract: In a method for manufacturing a modified enterovirus of ECHO 7 type by modification of native ECHO 7 virus, isolated by a known method from human feces and identified by genome sequence, the modification is performed initially conducting the virus adaptation in cancer cells, attenuated by anti-cancer agent dacarbazine, further passaging the modified virus in human embryonal fibroblast culture, followed by propagation in human melanoma cells and further passaging in human embryonal fibroblast culture, that was treated by ribavirin, isolation and purification by known method. The modified virus is suitable for treating various tumours.
    Type: Application
    Filed: September 27, 2018
    Publication date: May 16, 2019
    Inventors: Dite Venskus, Ivars Kalvins, Dace Pjanova, Ramona Petrovska, Jurgis Auzins
  • Patent number: 10174291
    Abstract: In a method for manufacturing a modified enterovirus of ECHO 7 type by modification of native ECHO 7 virus, isolated by a known method from human feces and identified by genome sequence, the modification is performed initially conducting the virus adaptation in cancer cells, attenuated by anti-cancer agent dacarbazine, further passaging the modified virus in human embryonal fibroblast culture, followed by propagation in human melanoma cells and further passaging in human embryonal fibroblast culture, that was treated by ribavirin, isolation and purification by known method. The modified virus is suitable for treating various tumours.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: January 8, 2019
    Assignee: Ditesan Ltd.
    Inventors: Dite Venskus, Ivars Kalvins, Dace Pjanova, Ramona Petrovska, Jurgis Auzins
  • Patent number: 10105348
    Abstract: Use of 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: October 23, 2018
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Liga Zvejniece, Maija Dambrova, Baiba Svalbe, Edijs Vavers, Ivars Kalvins, Grigorijs Veinbergs, Ilmars Stonans, Ilga Misane, Maksims Vorona, Aleksandrs Cernobrovijs
  • Publication number: 20180200227
    Abstract: Use of 2-(55-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.
    Type: Application
    Filed: August 2, 2016
    Publication date: July 19, 2018
    Inventors: Liga Zvejniece, Maija Dambrova, Baiba Svalbe, Edijs Vavers, Ivars Kalvins, Grigorijs Veinbergs, Ilmars Stonans, Ilga Misane, Maksims Vorona, Aleksandrs Cernobrovijs
  • Patent number: 9908893
    Abstract: The thieno[2,3-b]pyridines of general formula (I), wherein R1 is Me, C6H5, 3,4,5-(OMe)3C6H2, NH2; R2 is H, CN, COMe, COOC1-4alkyl, COOC2H4OMe, COOC2H4OPr(n); R3 is C6H4R6, 3,4-OCH2O—C6H3; 2-furanyl; R6 is 4-Cl, 4-NO2, 4-N(C1-4alkyl)2, 3-(C1-4alkyloxy), 4-(C1-4alkyloxy), 3,4-(C1-4alkyloxy)2, 3,4,5-(C1-4alkyloxy)3; R4 is NH2, NHCOMe; R5 is CN, COMe, COC6H4R7; CO-(2-naphthyl); R7 is H, 4-F, 4-Cl, 3-OMe, 4-OMe, 2,4-(OMe)2, 3,4,5-(OMe)3 as multidrug resistance modulators to increase the effectiveness of chemotherapy in cancer treatment.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: March 6, 2018
    Assignee: LATVIAN INSTITUTE OF ORGANIC SYNTHESIS
    Inventors: Ivars Kalvins, Aivars Krauze, Signe Grinberga, Laura Krasnova, Elina Jaschenko, Ilona Domracheva, Ilze Adlere, Zigmars Andzans, Irina Shestakova, Gunars Duburs
  • Patent number: 9573882
    Abstract: New compound 4-[ethyl(dimethyl)ammonio]butanoate, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: February 21, 2017
    Assignee: JSC GRINDEKS
    Inventors: Ivars Kalvins, Maija Dambrova, Edgars Liepins, Osvalds Pugovics, Reinis Vilskersts, Janis Kuka, Solveiga Grinberga, Einars Loza
  • Publication number: 20160376562
    Abstract: In a method for manufacturing a modified enterovirus of ECHO 7 type by modification of native ECHO 7 virus, isolated by a known method from human feces and identified by genome sequence, the modification is performed initially conducting the virus adaptation in cancer cells, attenuated by anti-cancer agent dacarbazine, further passaging the modified virus in human embryonal fibroblast culture, followed by propagation in human melanoma cells and further passaging in human embryonal fibroblast culture, that was treated by ribavirin, isolation and purification by known method. The modified virus is suitable for treating various tumours.
    Type: Application
    Filed: July 16, 2014
    Publication date: December 29, 2016
    Applicant: Ditesan Ltd
    Inventors: Dite Venskus, Ivars Kalvins, Dace Pjanova, Ramona Petrovska, Jurgis Auzins
  • Patent number: 9278907
    Abstract: New compound 4-[ethyl(dimethyl)ammonio]butanoate, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: March 8, 2016
    Assignee: JSC GRINDEKS
    Inventors: Ivars Kalvins, Maija Dambrova, Edgars Liepins, Osvalds Pugovics, Reinis Vilskersts, Janis Kuka, Solveiga Grinberga, Einars Loza
  • Patent number: 8940793
    Abstract: 4-[(Haloalkyl)(dimethyl)ammonio]butanoates of formula wherein Hal is Cl or F, n=1 or 2, method for preparing thereof and use thereof for treating cardiovascular disease.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: January 27, 2015
    Assignee: JSC Grindeks
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Ilmars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Viktors Andrianovs, Marina Makrecka, Daina Gustina, Solveiga Grinberga
  • Patent number: 8889902
    Abstract: Novel betaine salts of acetylsalicylic acid, namely 4-trimethylammoniobutanoate acetylsalicylic acid addition salt (gamma-butyrobetaine acetylsalicylate), L-carnitine acetylsalicylic acid addition salt and 3-(trimethylammonioamino)propanoate (meldonium) acetylsalicylic acid addition salt. Use of meldonium acetylsalicylate as antiplatelet agent for treating various pathologies induced by platelet aggregation, anti-inflammatory and antihyperlipidemic agent.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: November 18, 2014
    Assignee: Tetra, SIA
    Inventors: Ivars Kalvins, Anatolijs Birmans, Maris Veveris, Antons Lebedevs, Anatolijs Misnovs
  • Patent number: 8791273
    Abstract: The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: July 29, 2014
    Assignee: JSC Grindeks
    Inventors: Ivars Kalvins, Antons Lebedevs, Aleksandrs Cernobrovijs, Maija Dambrova, Liga Zvejniece, Maksims Vorona, Grigorijs Veinbergs
  • Publication number: 20140107202
    Abstract: 4-[(Haloalkyl)(dimethyl)ammonio]butanoates of formula wherein Hal is Cl or F, n=1 or 2, method for preparing thereof and use thereof for treating cardiovascular disease.
    Type: Application
    Filed: April 27, 2012
    Publication date: April 17, 2014
    Applicant: JSC GRINDEKS
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Ilmars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Viktos Andrianovs, Marina Makrecka, Daina Gustina, Solveiga Grinberga
  • Publication number: 20140088125
    Abstract: Salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 27, 2014
    Applicant: JSC Grindeks
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Limars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Reinis Vilskersts, Solveiga Grinberga
  • Publication number: 20130131126
    Abstract: 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type compounds having general formula I wherein R is hydrogen or carboxylate-methyl ester, R1 is sodium carboxylate-methyl ester R2 is methyl, ethyl or sodium carboxyate-methyl ester possessing antiviral efficacy.
    Type: Application
    Filed: July 15, 2011
    Publication date: May 23, 2013
    Applicant: JSC Grindeks
    Inventors: Ilmars Stonans, Ilze Jansone, Indra Jonane-Osa, Egils Bisenieks, Gunars Duburs, Ivars Kalvins, Brigita Vigante, Janis Uldrikis, Imanta Bruvere, Liga Zuka, Janis Poikans, Zaiga Neidere
  • Publication number: 20120220656
    Abstract: New compound 4-[ethyl(dimethyl)ammonio]butanoate, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Application
    Filed: October 22, 2010
    Publication date: August 30, 2012
    Applicant: JSC GRINDEKS
    Inventors: Ivars Kalvins, Maija Dambrova, Edgars Liepins, Osvalds Pugovics, Reinis Vilskersts, Janis Kuka, Solveiga Grinberga, Einars Loza