Patents by Inventor Ivars Y. Kalvinsh

Ivars Y. Kalvinsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5017611
    Abstract: The present invention relates to the art of organic chemistry. The novel compounds - ethyl-3-(2-ethyl-2,2-dimethylhydrazinium)-propionate salts have the general formula: ##STR1## wherein X is Cl, Br, I. The compounds of the present invention possess an antiarrhythmic effect.
    Type: Grant
    Filed: October 30, 1989
    Date of Patent: May 21, 1991
    Inventors: Gunar A. Bremanis, Felix Z. Meerson, Ivars Y. Kalvinsh, Nurlan Abdikaliev, Petr T. Trapentsier, Ma/Ya G. Pshennikova, Irene B. Antsena, Edmund Y. Lukevits, Boris Z. Simkhovich
  • Patent number: 4704403
    Abstract: Novel compounds, viz. 3-(2,2,2-trisubstituted hydrazinium) propionates have the following general formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are an alkyl, a substituted alkyl, a substituted or unsubstituted aryl, an aralkyl or an unsaturated alkyl;R.sup.4, R.sup.5 are hydrogen or a lower alkyl; n is 0 to 2, except for the case where R.sup.1, R.sup.2 and R.sup.3 are methyl, R.sup.4 and R.sup.5 are not hydrogen.The compounds of the present invention possess both hypotensive and antiarrhythmic activity and are useful in medicine.
    Type: Grant
    Filed: December 27, 1985
    Date of Patent: November 3, 1987
    Inventors: Gunar A. Bremanis, Ivars Y. Kalvinsh, Irene B. Antsena, Edmund Y. Lukevits, Maris M. Veveris, Marina L. Erenshtein, Valdis D. Mikazhan, Valeryans Y. Kauss, Edvard E. Liepinsh, Petr T. Trapentsier
  • Patent number: 4686215
    Abstract: The pharmaceutical composition possessing antitumor activity against tumors susceptible to 2-carbamoylaziridine which consists of a therapeutically efficaceous quantity of 1-H-2-aziridinecarbonic acid derivative having the formula ##STR1## where R is NH.sub.2 and a pharmaceutically suitable solvent or filler. The pharmaceutical composition possesses a high activity against tumors susceptible to 2-carbamoylaziridine, a wide spectrum of antitumor effect and low toxicity (LD.sub.50 within the range of 3,000 and 3,500 mg/kg. The invention is also a method for treating malignant tumors susceptible to 2-carbamoxylaziridine by administration of 2-carbamoyl-aziridine.
    Type: Grant
    Filed: January 22, 1985
    Date of Patent: August 11, 1987
    Assignee: Institut Organicheskogo Sinteza Akademii Nauk SSR
    Inventors: Ivars Y. Kalvinsh, Elena B. Astapenok
  • Patent number: 4633014
    Abstract: Substituted 3-hydrazinopropionates comprising compounds of the general fola: ##STR1## wherein R.sup.1, R.sup.2 =H, an alkyl, a substituted alkyl, hydroxycarbonyl, alkoxycarbonyl, an aryl, an aralkyl, an unsaturated alkyl, a substituted aryl or a substituted aralkyl: ##STR2## wherein R.sup.7, R.sup.8 =H, an alkyl, an unsaturated alkyl, an aralkyl, an aryl, a substituted alkyl,R.sup.9 =OH, an alkoxy, an aralkoxy, an alkyl, an unsaturated alkyl, an aryl, a substituted aryl, an aralkyl;R.sup.4 is --C.tbd.N, --COR.sup.10, wherein R.sup.10 =OR.sup.11, NR.sup.12 R.sup.13, where R.sup.11 is H, an alkyl, an aralkyl and an alkali metal, R.sup.11 and R.sup.12 are each H, an alkyl, an aralkyl, an aryl;R.sup.5, R.sup.6 = an alkyl, an aryl, an aralkyl.
    Type: Grant
    Filed: July 6, 1984
    Date of Patent: December 30, 1986
    Assignee: Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr
    Inventors: Gunar A. Bremanis, Ivars Y. Kalvinsh, Irene B. Antsena, Edmund Y. Lukevits, Maris M. Veveris, Valeryans Y. Kauss, Peter T. Trapentsier, Edvards E. Liepinsh
  • Patent number: 4568689
    Abstract: A novel pharmaceutical preparation for the treatment of hypertensive disease and myocardial infarction, which comprises as an active ingredient, (1,1-dimethyl-3-oxopyrazolidin-1-io-4-yl)acetate of the following formula: ##STR1## and a pharmaceutically acceptable vehicle.
    Type: Grant
    Filed: May 16, 1984
    Date of Patent: February 4, 1986
    Inventors: Ivars Y. Kalvinsh, Marina L Erenshtein, Gunar A. Bremanis, Valdis D. Mikazhan, Maris M. Veveris, Edmund Y. Lukevits, Edit A. Pule, Anatoly S. Birman
  • Patent number: 4481218
    Abstract: The novel compound according to the invention 3-(2,2,2-trimethylhydrazinium)-propionate has the general formula:(CH.sub.3).sub.3 NNHCH.sub.2 CH.sub.2 COO.2H.sub.2 O.The method for preparing this novel compound comprises passing a solution of 3-(2,2,2-grimethylhydrazinium) alkylpropionate of the formula:X.sup.- (CH.sub.3).sub.3 N.sup.+ NHCH.sub.2 CH.sub.2 COORwherein X is Cl, Br, I, CH.sub.3 SO.sub.4, R is a loawer alkyl, through a column with a strongly-basic anion exchange resin, followed by isolation of the desired product. The growth stimulator for animals and fowl contains the novel compound, i.e. 3-(2,2,2-trimethylhydrazinium)-propionate as the active principle.
    Type: Grant
    Filed: July 8, 1982
    Date of Patent: November 6, 1984
    Assignee: Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi SSR
    Inventors: Anatoly Eremeev, Ivars Y. Kalvinsh, Valentina G. Semenikhina, Edvards E. Liepinsh, Yan Y. Latvietis, Paul P. Anderson, Elena B. Astapenok, Yazep Y. Spruzh, Petr T. Trapentsiers, Gennady I. Podoprigora, Solomon A. Giller, deceased
  • Patent number: 4451485
    Abstract: A pharmaceutical composition for the treatment of cardio-vascular diseases comprising 3-(2,2,2-trimethylhydrazinium) propionate dihydrate of the following formula:(CH.sub.3).sub.3 N.sup.+ NHCH.sub.2 CH.sub.2 COO.sup.- .multidot.2H.sub.2 Oand a pharmaceutically acceptable diluent.
    Type: Grant
    Filed: September 17, 1982
    Date of Patent: May 29, 1984
    Assignee: Institu Organicheskogo Sinteza Akademii Nauk Latviiskoi SSR
    Inventors: Ivars Y. Kalvinsh, Alexei V. Vinogradov, Maris M. Veveris, Inna I. Makarova, Anatoly S. Birman, Georgy V. Barmotin, Oleg N. Akifiev