Patents by Inventor Ivo L. Jirkovsky

Ivo L. Jirkovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7276611
    Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are useful as intermediates in the preparation of ?-lactamase inhibitors.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: October 2, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Michael William Winkley, Anita Wai-Yin Chan, Ivo L. Jirkovsky, Kenneth Alfred Martin Kremer, Joseph Zeldis, Antonia Aristotelevna Nikitenko, Henry Lee Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam M. Venkatesan
  • Publication number: 20040242874
    Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification 1
    Type: Application
    Filed: May 12, 2004
    Publication date: December 2, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Michael William Winkley, Anita Wai-Yin Chan, Ivo L. Jirkovsky, Kenneth Alfred Martin Kremer, Joseph Zeldis, Antonia Aristotelevna Nikitenko, Henry Lee Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam M. Venkatesan
  • Patent number: 5389671
    Abstract: The present invention relates to novel 4- or 5-(substituted sulfonyl) methyl-3(2H)-furanones having the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl containing 1 to 6 branched or straight chain carbon atoms, phenyl, or halogen substituted phenyl; or R.sup.1 and R.sup.2 are joined by 5 to 7 carbon atoms;R.sup.3 and R.sup.4 are independently hydrogen, alkyl containing 1 to 6 branched or straight chain carbon atoms or R.sup.3 and R.sup.4 are joined by 4 to 6 carbon atoms;R.sup.
    Type: Grant
    Filed: February 16, 1994
    Date of Patent: February 14, 1995
    Assignee: American Home Products Corporation
    Inventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
  • Patent number: 5389673
    Abstract: The present invention relates to novel 4- or 5-(substituted sulfonyl) methyl-3(2H)-furanones having the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl containing 1 to 6 branched or straight chain carbon atoms, phenyl, or halogen substituted phenyl; or R.sup.1 and R.sup.2 are joined by 5 to 7 carbon atoms;R.sup.3 and R.sup.4 are independently hydrogen, alkyl containing 1 to 6 branched or straight chain carbon atoms or R.sup.3 and R.sup.4 are joined by 4 to 6 carbon atoms;R.sup.
    Type: Grant
    Filed: February 16, 1994
    Date of Patent: February 14, 1995
    Assignee: American Home Products Corporation
    Inventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
  • Patent number: 5389672
    Abstract: The present invention relates to novel 4- or 5-(substituted sulfonyl) methyl-3(2H)-furanones having the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl containing 1 to 6 branched or straight chain carbon atoms, phenyl, or halogen substituted phenyl; or R.sup.1 and R.sup.2 are joined by 5 to 7 carbon atoms;R.sup.3 and R.sup.4 are independently hydrogen, alkyl containing 1 to 6 branched or straight chain carbon atoms or R.sup.3 and R.sup.4 are joined by 4 to 6 carbon atoms;R.sup.
    Type: Grant
    Filed: February 16, 1994
    Date of Patent: February 14, 1995
    Assignee: American Home Products Corporation
    Inventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
  • Patent number: 5314913
    Abstract: The present invention relates to novel 4- or 5-(substituted sulfonyl)methyl-3(2H)-furanones having the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl containing 1 to 6 branched or straight chain carbon atoms, phenyl, or halogen substituted phenyl; or R.sup.1 and R.sup.2 are joined by 5 to 7 carbon atoms;R.sup.3 and R.sup.4 are independently hydrogen, alkyl containing 1 to 6 branched or straight chain carbon atoms or R.sup.3 and R.sup.4 are joined by 4 to 6 carbon atoms;R.sup.
    Type: Grant
    Filed: December 8, 1992
    Date of Patent: May 24, 1994
    Assignee: American Home Products Corporation
    Inventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
  • Patent number: 5236941
    Abstract: 5-(2-Hydroxy-1-phenyl (or-1-naphthalenyl)ethylidene) and 5-(2-oxo-1-phenyl (or 1-naphthalenyl)ethylidene)-2,4-thiazolidinediones and derivatives thereof are useful in lowering blood glucose levels in a hyperglycemic laboratory animal model and are thus useful in the treatment of diabetes mellitus.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: August 17, 1993
    Assignee: American Home Products Corporation
    Inventors: Arie Zask, Ivo L. Jirkovsky
  • Patent number: 5118675
    Abstract: The compounds of the formula: ##STR1## in which Q is the quinoxaline nucleus; m is one of the integers 0, 1 or 2; n is one of the integers 1,2 or 3; or a pharmaceutically acceptable salt, alkyl ester or ##STR2## where R.sup.3 and R.sup.4 are, independently, hydrogen, nitro, halo or methoxy, are NMDA antagonists useful in the treatment and prevention of central nervous system related pathological conditions resulting from overstimulation by excitatory amino acids.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: June 2, 1992
    Assignee: American Home Products Corporation
    Inventors: Ivo L. Jirkovsky, Reinhardt B. Baudy, Lynne P. Greenblatt
  • Patent number: 5026725
    Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: June 25, 1991
    Assignee: American Home Products Corporation
    Inventors: Marshall A. Hayward, Joseph P. Sabatucci, Ivo L. Jirkovsky, Yvon Lefebvre
  • Patent number: 5017601
    Abstract: A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substituents selected from halo, alkyl, alkythio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: May 21, 1991
    Assignee: American Home Products Corporation
    Inventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
  • Patent number: 5010102
    Abstract: A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substiuents selected from halo, alkyl, alkylthio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: April 23, 1991
    Assignee: American Home Products Corp.
    Inventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
  • Patent number: 5001126
    Abstract: A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substituents selected from halo, alkyl, alkylthio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: March 19, 1991
    Assignee: American Home Products Corporation
    Inventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
  • Patent number: 4966905
    Abstract: A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substituents selected from halo, alkyl, alkylthio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.
    Type: Grant
    Filed: December 12, 1989
    Date of Patent: October 30, 1990
    Assignee: American Home Products Corporation
    Inventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
  • Patent number: 4916241
    Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: April 10, 1990
    Assignee: American Home Products Corporation
    Inventors: Marshall A. Hayward, Joseph P. Sabatucci, Ivo L. Jirkovsky, Yvon Lefebvre
  • Patent number: 4778812
    Abstract: Herein is disclosed 2,3-dihydro-9-methyl-1H-pyrrolo[1,2-a]indol-1-amines and derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives, and pharmaceutical compositions. The derivatives are chemically novel agents with antihypoxic, cerebroactive, and cognition activating properties.
    Type: Grant
    Filed: June 12, 1987
    Date of Patent: October 18, 1988
    Assignee: American Home Products Corporation
    Inventor: Ivo L. Jirkovsky
  • Patent number: 4492697
    Abstract: The invention discloses novel 4H-imidazo[2,3-c]pyrido[2,3-e][1,4]oxazine derivatives, processes for their preparation, pharmaceutical compositions thereof and methods for using the compounds. The compounds of this invention are useful in the treatment of anaphylactic reactions and allergic conditions in a mammal.
    Type: Grant
    Filed: August 16, 1983
    Date of Patent: January 8, 1985
    Assignee: Ayerst, McKenna & Harrison, Inc.
    Inventors: Jean A. Gauthier, Ivo L. Jirkovsky
  • Patent number: 4409224
    Abstract: Pyrimido[1,6-a]indole derivatives characterized by having a substituted ethyl group at position 5 and optionally being further substituted at various positions on the pyrimido[1,6-a]indole nucleus are disclosed. The foregoing compounds are useful as antihypertensive agents in a mammal. Methods for their preparation also are disclosed.
    Type: Grant
    Filed: July 13, 1981
    Date of Patent: October 11, 1983
    Assignee: American Home Products Corp.
    Inventor: Ivo L. Jirkovsky
  • Patent number: 4355031
    Abstract: Pyrazinoisoindolone derivatives of the formula ##STR1## wherein R.sup.1 is lower alkyl, phenyl, diphenylmethyl, pyridinyl, pyrimidinyl, pyrazinyl or pyrazinyl substituted with a lower alkyl, lower alkoxy or halo; and R.sup.2 is hydrogen, lower alkyl or di(lower)alkylamino(lower)alkyl are useful as antihypertensive agents.
    Type: Grant
    Filed: May 11, 1981
    Date of Patent: October 19, 1982
    Assignee: American Home Products Corp.
    Inventors: Christopher A. Demerson, Ivo L. Jirkovsky
  • Patent number: 4351942
    Abstract: A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.
    Type: Grant
    Filed: January 7, 1980
    Date of Patent: September 28, 1982
    Assignee: American Home Products Corp.
    Inventors: Thomas A. Dobson, Leslie G. Humber, Christopher A. Demerson, Ivo L. Jirkovsky
  • Patent number: 4307092
    Abstract: This invention discloses novel 1-oxo-5H-pyrimidol[2,1-c][1,4]benzoxa(or thia)zinc-2-carboxylic acid lower alkyl esters, derivatives thereof, process for their preparation, pharmaceutical compositions thereof and methods for using the compounds. The compounds of this invention are useful in the treatment of anaphylactic reactions and allergic conditions in a mammal.
    Type: Grant
    Filed: July 22, 1980
    Date of Patent: December 22, 1981
    Assignee: Ayerst McKenna & Harrison, Inc.
    Inventors: Jean A. Gauthier, Ivo L. Jirkovsky