Patents by Inventor Ivo Lieberam

Ivo Lieberam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for inducing differentiation of embryonic stem cells and uses thereof
    Patent number: 7390659
    Abstract: The present invention provides a method for inducing differentiation of an embryonic stem cell into a differentiated neural cell. The present invention further provides a method for producing differentiated neural cells, and a population of cells comprising the differentiated neural cells. Additionally, the present invention provides a method for repopulating a spinal cord in a subject, and a method for treating nervous tissue degeneration in a subject in need of treatment. The present invention further provides neural progenitor cells, differentiated neural cells, and uses of same. Also provided is a transgenic non-human animal containing the differentiated neural cells. The present invention is further directed to a method for isolating a population of differentiated neural cells. Finally, the present invention provides a method for identifying an agent for use in treating a condition associated with neuron degeneration.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: June 24, 2008
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Thomas Jessell, Hynek Wichterle, Ivo Lieberam
  • Systems and methods for screening for modulators of neural differentiation
    Publication number: 20070224650
    Abstract: The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of an FGF signalling pathway, a modulator of FGF-dependent neural differentiation, a modulator of a retinoid signalling pathway, and a modulator of retinoid-dependent neural differentiation. Also provided are modulators identified by these methods.
    Type: Application
    Filed: August 25, 2006
    Publication date: September 27, 2007
    Inventors: Thomas Jessell, Hynek Wichterle, Sara Wilson, Ivo Lieberam
  • Systems and methods for screening for modulators of neural differentiation
    Publication number: 20070185024
    Abstract: The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of a Wnt signalling pathway, a modulator of Wnt-dependent neural differentiation, a modulator of a BMP signalling pathway, a modulator of BMP-dependent neural differentiation, a modulator of a Hh signalling pathway, and a modulator of Hh-dependent neural differentiation. Also provided are modulators identified by these methods.
    Type: Application
    Filed: August 25, 2006
    Publication date: August 9, 2007
    Inventors: Thomas Jessell, Hynek Wichterle, Sara Wilson, Ivo Lieberam
  • Methods for inducing differentiation of embryonic stem cells and uses thereof
    Publication number: 20040014210
    Abstract: The present invention provides a method for inducing differentiation of an embryonic stem cell into a differentiated neural cell. The present invention further provides a method for producing differentiated neural cells, and a population of cells comprising the differentiated neural cells. Additionally, the present invention provides a method for repopulating a spinal cord in a subject, and a method for treating nervous tissue degeneration in a subject in need of treatment. The present invention further provides neural progenitor cells, differentiated neural cells, and uses of same. Also provided is a transgenic non-human animal containing the differentiated neural cells. The present invention is further directed to a method for isolating a population of differentiated neural cells. Finally, the present invention provides a method for identifying an agent for use in treating a condition associated with neuron degeneration.
    Type: Application
    Filed: July 16, 2002
    Publication date: January 22, 2004
    Inventors: Thomas M. Jessell, Hynek Wichterle, Ivo Lieberam