Abstract: Disclosed herein are materials, articles of manufacture, and methods for decreasing, mitigating, removing or precluding formation of an amount of a nitrosating agent and/or an N-nitroso compound, including an N-nitrosamine, in an enclosure of a pharmaceutical drug package to inhibit a potential adverse health effect on a patient associated with the nitrosating agent or N-nitroso compound. The package contains an active agent and a pharmaceutical dosage form in an enclosure of the package. The active agent, consisting essentially of sodium bicarbonate in a granular, particulate or powdered form, is effective to decrease, mitigate, remove or preclude the formation of an amount of the nitrosating agent and/or N-nitroso compound in the enclosure and/or in the pharmaceutical dosage form. Also provided are drug delivery systems including a blister pack configured to house multiple pharmaceutical dosage forms, the blister pack including an active agent as discussed above.

Abstract: Disclosed herein are materials, articles of manufacture, and methods for reducing, mitigating, or precluding formation of and/or amount of a nitrosating agent and/or an N-nitroso compound, including an N-nitrosamine, from a packaging containing an active agent and a pharmaceutical dosage form in an enclosure, wherein the active agent is effective to reduce mitigate or preclude the formation and/or amount of a nitrosating agent and/or N-nitroso compound in the enclosure and/or in the pharmaceutical dosage form. Provided are drug delivery systems comprising a blister pack configured to house multiple pharmaceutical dosage forms, the blister pack comprising an active ingredient that is effective to reduce, mitigate or preclude the formation and/or amount of a nitrosating agent and/or N-nitroso compound in an enclosure of the blister pack and/or in the pharmaceutical dosage form.

Abstract: This disclosure relates to a composition, a system and a method of reducing and preventing the growth of microbes, or for killing microbes. More particularly, the disclosure relates to a composition, a system and a method of reducing and preventing growth of microbes, or for killing microbes, e.g., in food and medical equipment containers, using polymers entrained with antimicrobial agents.