Patents by Inventor Iwan Gunawan

Iwan Gunawan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7531564
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: May 12, 2009
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, C. Richard Lyttle
  • Publication number: 20070167503
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 11, 2006
    Publication date: July 19, 2007
    Applicant: Wyeth
    Inventors: Michael Malamas, Robert McDevitt, Iwan Gunawan, Eric Manas, Michael Collini, Heather Harris, James Keith, Leo Albert, C. Richard Lyttle
  • Publication number: 20070027199
    Abstract: The present invention provides a 2-amino-5-cycloalkyl-hydantoin compound of formula I The present invention also provides methods and compositions for the inhibition of ?-secretase (BACE) and the treatment of ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: July 28, 2006
    Publication date: February 1, 2007
    Applicant: Wyeth
    Inventors: Michael Malamas, Iwan Gunawan, James Erdei, Pawel Nowak, Joseph Stock, Yinfa Yan
  • Publication number: 20070004786
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: June 29, 2006
    Publication date: January 4, 2007
    Applicant: Wyeth
    Inventors: Michael Malamas, Ping Zhou, William Fobare, William Solvibile, Iwan Gunawan, James Erdei, Yinfa Yan, Patrick Andrae, Dominick Quagliato
  • Patent number: 7148247
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: December 12, 2006
    Assignee: Wyeth
    Inventors: Michael S Malamas, Robert E McDevitt, Iwan Gunawan, Eric S Manas, Michael D Collini, Heather A Harris, James C Keith, Jr., Leo M Albert, Cecil Richard Lyttle
  • Patent number: 7129258
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: October 31, 2006
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini
  • Publication number: 20060160828
    Abstract: The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: January 13, 2006
    Publication date: July 20, 2006
    Applicant: Wyeth
    Inventors: Michael Malamas, James Erdei, Iwan Gunawan, Pawel Nowak, Boyd Harrison
  • Publication number: 20050282826
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Application
    Filed: June 15, 2005
    Publication date: December 22, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, James Erdei, Iwan Gunawan, Keith Barnes, Matthew Johnson, Yu Hui
  • Publication number: 20050282825
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Application
    Filed: June 15, 2005
    Publication date: December 22, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, James Erdei, Iwan Gunawan, Ping Zhou, Yinfa Yan, Dominick Quagliato
  • Publication number: 20050272786
    Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure wherein, A is wherein R1, R2, R3, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 30, 2005
    Publication date: December 8, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, Iwan Gunawan, Heather Harris, James Keith, Leo Albert
  • Patent number: 6960607
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: November 1, 2005
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Iwan Gunawan, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Publication number: 20050239851
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 17, 2004
    Publication date: October 27, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, Robert McDevitt, Iwan Gunawan, Eric Manas, Michael Collini, Heather Harris, James Keith, Leo Albert, C. Lyttle
  • Publication number: 20050159465
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, and R3 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 1, 2005
    Publication date: July 21, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, Tam Dinh, Iwan Gunawan, Michael Collini, Heather Harris, James Keith, Leo Albert
  • Patent number: 6884814
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: April 26, 2005
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Tam Q. Dinh, Iwan Gunawan, Michael D. Collini, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Publication number: 20050080117
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 19, 2004
    Publication date: April 14, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, Robert McDevitt, Iwan Gunawan, Eric Manas, Michael Collini
  • Patent number: 6844358
    Abstract: This invention provides compounds of Formula I having the structure wherein: A is O, S, or N; B is —(CH2)m—, —CH(OH)—, or carbonyl; R1 is hydrogen, halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, or trifluoromethyl; R2 is alkyl of 1-18 carbon atoms, aryl of 6-10 carbon atoms, arylalkyl of 7-15 carbon atoms, Het-alkyl wherein the alkyl moiety is 1-6 carbon atoms; Het is R2a is alkylene of 1-3 carbon atoms; G is oxygen, sulfur, or nitrogen; R3, R4 are each, independently, hydrogen, halogen, alkyl of 1-3 carbon atoms, aryl of 6-10 carbon atoms or a heterocyclic ring of 5 to 7 ring atom containing 1 to 3 heteroatoms selected from oxygen, nitrogen, sulfur; R5 is hydrogen, alkyl of 1-6 carbon atoms, —CH(R7)R8, —C(CH2)nCO2R9, —C(CH3)2CO2R9, —CH(R7)(CH2)nCO2R9, or CH(R7)C6H4CO2R9; R6 is hydrogen, halogen, alkyl of 1-6 carbon atoms, or —OR5; m=1-6; n=1-6; R7 is hydrogen, alkyl of 1-6 carbon atoms, aryl of 6-10 carbon atoms, or arylalkyl of 7-15 carbon atoms; R8 is —CO2R10, —CONHR10, tetrazol
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: January 18, 2005
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Jay E. Wrobel, Arlene J. Dietrich, Zenan Li, Iwan Gunawan
  • Patent number: 6794403
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: September 21, 2004
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini
  • Publication number: 20040102480
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: November 21, 2002
    Publication date: May 27, 2004
    Applicant: Wyeth
    Inventors: Michael S. Malamas, Jay E. Wrobel, Arlene J. Dietrich, Zenan Li, Iwan Gunawan
  • Publication number: 20030207927
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: November 6, 2003
    Applicant: Wyeth
    Inventors: Michael S. Malamas, Tam Q. Dinh, Iwan Gunawan, Michael D. Collini, Heather A. Harris, James C. Keith, Leo M. Albert
  • Publication number: 20030199562
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 4, 2002
    Publication date: October 23, 2003
    Applicant: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini, Heather A. Harris, James C. Keith, Leo M. Albert, C. Richard Lyttle