Abstract: A phase correlation method (PCM) can be used for translational and/or rotational alignment of 3D medical images even in the presence of non-rigid deformations between first and second images of a registered volume of a patient.

Abstract: A target volume within a test object is irradiated according to an irradiation plan with a particle beam using a particle irradiation unit. The irradiation plan is determined in order to apply the energy of the particle beam in the target volume according to a predetermined dose distribution. In addition, a boundary condition is specified for at least one of the isoenergy layers and the irradiation plan is additionally specified such that the boundary condition is met for the at least one isoenergy layer. The boundary condition includes one or more of a minimum boundary energy, a maximum boundary energy, a minimum grid point number, a minimum total particle number, a minimum total dose, a minimum dose contribution to a total dose to be administered, a minimum contribution to a target function which is calculated for determining the irradiation plan, and a minimum dose compensation error.

Abstract: Disclosed herein are methods including calibrating a radiotherapy machine to identify an effective radiation source size of a radiation source contained within the radiotherapy machine, the radiation source having a nominal radiation source size, to improve accuracy of a predicted dose profile for one or more radiation beams from the radiation source to further improve accuracy of radiation dose calculation and treatment delivery.

Abstract: A method and a device for regulating a therapeutic beam directed at an object are provided. The method includes displaying at least one multidimensional image data record encompassing at least one target area of the object. The method also includes determining the treatment beam dosage directed at the at least one target area, and recording and optionally visualizing an isoline or isosurface dependent on the treatment beam dosage in the at least one multidimensional image data record. The method includes adjusting the isoline or isosurface such that the isoline or isosurface approximates a contour of the target area as closely as possible or corresponds to the contour, and regulating the treatment beam dosage by evaluation of the adjusted isoline or isosurface.

Abstract: A target volume within a test object is irradiated according to an irradiation plan with a particle beam using a particle irradiation unit. The irradiation plan is determined in order to apply the energy of the particle beam in the target volume according to a predetermined dose distribution. In addition, a boundary condition is specified for at least one of the isoenergy layers and the irradiation plan is additionally specified such that the boundary condition is met for the at least one isoenergy layer. The boundary condition includes one or more of a minimum boundary energy, a maximum boundary energy, a minimum grid point number, a minimum total particle number, a minimum total dose, a minimum dose contribution to a total dose to be administered, a minimum contribution to a target function which is calculated for determining the irradiation plan, and a minimum dose compensation error.

Abstract: A phase correlation method (PCM) can be used for translational and/or rotational alignment of 3D medical images even in the presence of non-rigid deformations between first and second images of a registered volume of a patient.

Abstract: A method for determining a 4D plan for carrying out intensity-modulated radiation therapy of a target volume subject to irregular periodic motion, with a radiation therapy apparatus is provided. The method includes selecting positions of a radiation source. The number of positions is selected to be identical in all 3D radiation therapy plans. The method also includes selecting a number of respective aperture settings assigned to a respective position of the radiation source to be identical in all 3D radiation therapy plans. A geometrical, temporal, and/or dynamic restriction that restricts a change of the aperture from one aperture setting to another aperture setting is predetermined, and the 3D radiation therapy plans are determined such that the 3D radiation therapy plans fulfill predetermined restrictions for aperture settings in each case.

Abstract: A method for determining a 4D plan for carrying out intensity-modulated radiation therapy of a target volume subject to irregular periodic motion, with a radiation therapy apparatus is provided. The method includes selecting positions of a radiation source. The number of positions is selected to be identical in all 3D radiation therapy plans. The method also includes selecting a number of respective aperture settings assigned to a respective position of the radiation source to be identical in all 3D radiation therapy plans. A geometrical, temporal, and/or dynamic restriction that restricts a change of the aperture from one aperture setting to another aperture setting is predetermined, and the 3D radiation therapy plans are determined such that the 3D radiation therapy plans fulfill predetermined restrictions for aperture settings in each case.

Abstract: A method and a device for regulating a therapeutic beam directed at an object are provided. The method includes displaying at least one multidimensional image data record encompassing at least one target area of the object. The method also includes determining the treatment beam dosage directed at the at lest one target area, and recording and optionally visualizing an isoline or isosurface dependent on the treatment beam dosage in the at least one multidimensional image data record. The method includes adjusting the isoline or isosurface such that the isoline or isosurface approximates a contour of the target area as closely as possible or corresponds to the contour, and regulating the treatment beam dosage by evaluation of the adjusted isoline or isosurface.