Patents by Inventor Iwan Märki
Iwan Märki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230400464Abstract: The present invention relates to a method for assessing the severity of Severe Acute Respiratory Syndrome (SARS) in a patient; said method being based on a severity score consisting of at least: a) a respiratory system score, b) a score determined by the level of pancreatic stone protein/regenerating protein (PSP/reg) in a body fluid sample from said patient.Type: ApplicationFiled: November 3, 2020Publication date: December 14, 2023Inventors: Nicolas DURAND, Iwan MÄRKI, François VENTURA
-
Patent number: 10617303Abstract: A functional optical coherent imaging (fOCI) platform includes at least one active camera unit (ACU) having a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD.Type: GrantFiled: July 28, 2017Date of Patent: April 14, 2020Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Theo Lasser, Dimitri Van De Ville, Erica Martin-Williams, Marcel Leutenegger, Iwan Maerki, Michael Friedrich, Martin Villiger
-
Patent number: 10434508Abstract: A capsule (100) comprising a housing (110) in which are disposed nanofluidic biosensors (120), a fluid connecting element (140), a filter (150) and a cover (160) is described. The capsule (100) allows the analysis of a fluid sample (300) that would be deposited in the capsule system (100) by a pipette (400). The fluid sample (300) is filtered when passing through a filter (150), then transferred by a fluid connecting element (140) to the inlets of one or several nanofluidic biosensors (120). The capsule system (100) is disposed on an external support (200), and finally an optical or an electrical measurement unit (500) is used to measure the molecular interactions in the nanofluidic biosensors.Type: GrantFiled: June 23, 2015Date of Patent: October 8, 2019Assignee: Abionic SAInventors: Iwan Maerki, Lauriane Carrere, Nicolas Durand
-
Patent number: 10166540Abstract: A nanofluidic biosensor system (200) comprising a bottom substrate (120) and a top substrate (110) between which are defined an input lateral aperture (210), a nanoslit (230) which contains at least one functionalized area (231) and an output lateral aperture (220) or an internal reservoir (221), said biosensor system (200) being adapted to let a solution containing biomolecules (320) enter the input lateral aperture (210) and successively pass through said nanoslit (230) and said output lateral aperture (220) or internal reservoir (221); said biosensor system (200) furthermore comprising a gas evacuation subsystem (150-155) which is located between said nanoslit (230) and the biosensor external environment.Type: GrantFiled: December 17, 2014Date of Patent: January 1, 2019Assignee: Abionic SAInventors: Nicolas Durand, Iwan Maerki, Matthias Geissbuehler
-
Patent number: 9989526Abstract: A method and device for multiplexing and calibrating rapid quantification of biomolecules present in a nanofluidic biosensor composed by a nanoslit. A novel concept defining multiple different local structured areas containing biomarkers. Local structured areas can also be structured to decrease the biomarkers density in the nanoslit. Such enables the multiplexed quantification biomolecular interactions of interest in the same nanofluidic biosensor.Type: GrantFiled: July 7, 2014Date of Patent: June 5, 2018Assignee: ABIONIC SAInventors: Nicolas Durand, Iwan Märki, Annick Mayor, Stéphane Broillet
-
Publication number: 20180098702Abstract: A functional optical coherent imaging (fOCI) platform includes at least one active camera unit (ACU) having a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit. SAU); and an operator interface (HOD.Type: ApplicationFiled: July 28, 2017Publication date: April 12, 2018Inventors: Theo LASSER, Dimitri VAN DE VILLE, Erica MARTIN-WILLIAMS, Marcel LEUTENEGGER, Iwan MAERKI, Michael FRIEDRICH, Martin VILLIGER
-
Patent number: 9757039Abstract: A functional optical coherent imaging (fOCI) platform includes at least one active camera unit (ACU) having a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD.Type: GrantFiled: June 29, 2015Date of Patent: September 12, 2017Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Theo Lasser, Dimitri Van De Ville, Erica Martin-Williams, Marcel Leutenegger, Iwan Maerki, Michael Friedrich, Martin Villiger
-
Publication number: 20170197210Abstract: A capsule (100) comprising a housing (110) in which are disposed nanofluidic biosensors (120), a fluid connecting element (140), a filter (150) and a cover (160) is described. The capsule (100) allows the analysis of a fluid sample (300) that would be deposited in the capsule system (100) by a pipette (400). The fluid sample (300) is filtered when passing through a filter (150), then transferred by a fluid connecting element (140) to the inlets of one or several nanofluidic biosensors (120). The capsule system (100) is disposed on an external support (200), and finally an optical or an electrical measurement unit (500) is used to measure the molecular interactions in the nanofluidic biosensors.Type: ApplicationFiled: June 23, 2015Publication date: July 13, 2017Inventors: Iwan Maerki, Lauriane Carrere, Nicolas Durand
-
Patent number: 9547004Abstract: A method and device for the rapid quantification of biomolecules (320) present in a nanochannel (210) is claimed. In particular, the present invention relates to a novel concept of liquid actuation and selectively functionalized surfaces in a nanochannel that create a concentration gradient of transitory immobilized biomolecules (340) across the nanochannel. The present concept enables the quantification of biomolecular interactions of interest (320).Type: GrantFiled: February 6, 2012Date of Patent: January 17, 2017Assignee: ABIONIC SAInventors: Nicolas Durand, Iwan Märki, Stéphane Broillet, Annick Mayor, Theo Lasser
-
Publication number: 20160367145Abstract: A functional optical coherent imaging (fOCI) platform includes at least one active camera unit (ACU) having a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD.Type: ApplicationFiled: June 29, 2015Publication date: December 22, 2016Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Theo LASSER, Dimitri VAN DE VILLE, Erica MARTIN-WILLIAMS, Marcel LEUTENEGGER, Iwan MAERKI, Michael FRIEDRICH, Martin VILLIGER
-
Publication number: 20160339432Abstract: A nanofluidic biosensor system (200) comprising a bottom substrate (120) and a top substrate (110) between which are defined an input lateral aperture (210), a nanoslit (230) which contains at least one functionalized area (231) and an output lateral aperture (220) or an internal reservoir (221), said biosensor system (200) being adapted to let a solution containing biomolecules (320) enter the input lateral aperture (210) and successively pass through said nanoslit (230) and said output lateral aperture (220) or internal reservoir (221); said biosensor system (200) furthermore comprising a gas evacuation subsystem (150-155) which is located between said nanoslit (230) and the biosensor external environment.Type: ApplicationFiled: December 17, 2014Publication date: November 24, 2016Inventors: Nicolas Durand, Iwan Maerki, Matthias Geissbuehler
-
Patent number: 9452927Abstract: A method and device for the rapid detection of biomolecules (320) diffusing in a nanometer-confined slit (204) is claimed. In particular, the present invention relates to a novel concept of fluidic side apertures (205) that facilitates the filling of the device, the surface coating with biomolecules and that measures the affinity between fluorescently labeled biomolecules in aqueous solution with other biomolecules immobilized on surfaces.Type: GrantFiled: November 19, 2010Date of Patent: September 27, 2016Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Nicolas Durand, Yannick Fournier, Theo Lasser, Iwan Märki
-
Publication number: 20160153980Abstract: A method and device for multiplexing and calibrating rapid quantification of biomolecules present in a nanofluidic biosensor composed by a nanoslit (210) is claimed. In particular, the present invention relates to a novel concept defining multiple different functionalized areas containing biomarkers. Functionalized areas can also being structured to decrease the biomarkers density in the nanoslit. The present concept enables the multiplexed quantification biomolecular interactions of interest in the same nanofluidic biosensor.Type: ApplicationFiled: July 7, 2014Publication date: June 2, 2016Inventors: Nicolas DURAND, Iwan MÄRKI, Annick MAYOR, Stéphane BROILLET
-
Patent number: 9066686Abstract: The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD.Type: GrantFiled: July 10, 2008Date of Patent: June 30, 2015Assignee: Novadaq Technologies Inc.Inventors: Theo Lasser, Dimitri Van De Ville, Erica Martin-Williams, Marcel Leutenegger, Iwan Maerki, Michael Friedrich, Martin Villiger
-
Patent number: 8938103Abstract: A method and system for the rapid detection of biomolecular interactions, the system comprising a sensing platform which comprises a primary support structure including recesses designed to be located in front of a detection unit, said recesses containing one or several arrays of biosensors, said system furthermore comprising a reader unit for optical excitation and detection.Type: GrantFiled: February 25, 2011Date of Patent: January 20, 2015Assignee: Ecole Polytechnique Ferderale de Lausanne (EPFL)Inventors: Nicolas Durand, Iwan Märki, Theo Lasser
-
Publication number: 20140256573Abstract: A method and device for the rapid quantification of biomolecules (320) present in a nanochannel (210) is claimed. In particular, the present invention relates to a novel concept of liquid actuation and selectively functionalized surfaces in a nanochannel that create a concentration gradient of transitory immobilized biomolecules (340) across the nanochannel. The present concept enables the quantification of biomolecular interactions of interest (320).Type: ApplicationFiled: February 6, 2012Publication date: September 11, 2014Applicant: ABIONIC SAInventors: Nicolas Durand, Iwan Märki, Stéphane Broillet, Annick Mayor, Theo Lasser
-
Publication number: 20130017967Abstract: A method and device for the rapid detection of biomolecules (320) diffusing in a nanometer-confined slit (204) is claimed. In particular, the present invention relates to a novel concept of fluidic side apertures (205) that facilitates the filling of the device, the surface coating with biomolecules and that measures the affinity between fluorescently labeled biomolecules in aqueous solution with other biomolecules immobilized on surfaces.Type: ApplicationFiled: November 19, 2010Publication date: January 17, 2013Inventors: Nicolas Durand, Yannick Fournier, Theo Lasser, Iwan Märki
-
Publication number: 20130016887Abstract: A method and system for the rapid detection of biomolecular interactions, the system comprising a sensing platform which comprises a primary support structure including recesses designed to be located in front of a detection unit, said recesses containing one or several arrays of biosensors, said system furthermore comprising a reader unit for optical excitation and detection.Type: ApplicationFiled: February 25, 2011Publication date: January 17, 2013Inventors: Nicolas Durand, Iwan Märki, Theo Lasser
-
Publication number: 20110169978Abstract: The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD.Type: ApplicationFiled: July 10, 2008Publication date: July 14, 2011Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Theo Lasser, Dimitri Van De Ville, Erica Martin-Williams, Marcel Leutenegger, Iwan Maerki, Michael Friedrich, Martin Villiger