Abstract: A composition containing nicotine and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer is applied on the skin of patients in the form of a gel, ointment, solution, suspension or film which slowly releases nicotine and creates levels of the drug in the blood to reduce nicotine-craving in smokers, thereby assisting in smoking-cessation programs.

Abstract: A composition containing nicotine and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer is applied on the skin of patients in the form of a gel, ointment, solution, suspension or film which slowly releases nicotine and creates levels of the drug in the blood to reduce nicotine-craving in smokers, thereby assisting in smoking-cessation programs.

Abstract: A pharmaceutical and cosmetical preparation which rapidly penetrates through human skin, and which thus is able to bring about the rapid transdermal penetration of a wide variety of active ingredients. The compounds which enhance the rate of dermal penetration are also anti-oxidative agents and thus protect active substances susceptible to oxidative degradation. Preferred agents enhancing penetration and which protect against oxidation are higher esters and higher amides of thioglycolic acid and of mercaptopropionic acid. The preparations can be in the form of mixtures or there may be prepared chemical compounds which are a combination of the active substance and the said thioacids.

Abstract: Composition for the treatment of gingivitis and other afflictions of the oral cavity, as well as for the reduction of dental plaque. These are in the form of gels, solutions or similar forms which comprise a therapeutically active agent in a polymeric carrier which contains a solvent. The nature of the preparation is such that when these are applied to an aqueous environment of the oral cavity, the polymer and the active agent precipitate and form a coating.

Abstract: The invention comprises compositions and methods for the treatment of psoriasis.

Abstract: The invention comprises compositions and methods for the treatment of psoriasis.

Abstract: A mixture of estradiol or other estrogen and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer provides a matrix which gradually releases the medicament upon application to the skin of a patient in the form of an ointment, gel or film. The polymer provides for the slow and sustained release of the medicament upon topical application to the skin so that the concentration of drug in the blood plasma of the patient is maintained within the levels required for clinical efficacy.

Abstract: The invention comprises compositions and methods for the treatment of psoriasis.

Abstract: A mixture of estradiol or other estrogen and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer provides a matrix which gradually releases the medicament upon application to the skin of a patient in the form of an ointment, gel or film. The polymer provides for the slow and sustained release of the medicament upon topical application to the skin so that the concentration of drug in the blood plasma of the patient is maintained within the levels required for clinical efficacy.

Abstract: A mixture of nitroglycerin and a water-insoluble vinylpyrrolidone polymer provides a polymeric matrix which gradually releases nitroglycerin upon application to the skin of a patient in the form of a film, gel or ointment. The water-insoluble vinylpyrrolidone polymer may be an uncrosslinked copolymer or a crosslinked homopolymer or copolymer. The polymer provides increased stability and reduced volatility of the nitroglycerin while permitting slow and sustained release of the drug upon topical application to the skin.

Abstract: A mixture of nitroglycerin and a water-insoluble vinylpyrrolidone polymer provides a polymeric matrix which gradually releases nitroglycerin upon application to the skin of a patient in the form of a film, gel or ointment. The water-insoluble vinylpyrrolidone polymer may be an uncrosslinked copolymer or a crosslinked homopolymer or copolymer. The polymer provides increased stability and reduced volatility of the nitroglycerin while permitting slow and sustained release of the drug upon topical application to the skin.

Abstract: A salt of a polymer, containing acid groups, soluble or dispersible in water or organic solvents, is combined with a salt-forming pharmaceutically effective compound for application, orally, topically, or systemically. A sustained release of the pharmaceutical compound is thus obtained.

Abstract: A composition comprising a copolymer of from 20 to 60 parts of at least one member selected from the class consisting of acrylic and methacrylic acids, from 20 to 70 parts of one member selected from the class of lower alkyl acrylates and lower alkyl methacrylates, and from 5 to 20 parts of a plasticizing monomer, in which at least some of the acid groups have been neutralized by multivalent cations, where a chemical, exclusive of water and plasticizer, releasable from a film of the referenced copolymer, is formed by casting and drying an aqueous solution of the copolymer containing the chemical.

Abstract: A copolymer derived from a monomeric mixture comprising from 20 to 60 parts of acrylic or methacrylic acid, from 20 to 70 parts of a lower alkyl acrylate or methacrylate, and from 5 to 20 parts of a plasticizing monomer is at least partially neutralized by multivalent cations.

Abstract: Copolymers comprising acrylic or methacrylic acid and methyl methacrylate are neutralized by the addition of cyclic alkylene imines, preferably ethylene imine, to form a product which is capable of absorbing large amounts of material soluble in water, and slowly releasing those materials. The fundamental copolymer may be modified by the addition of cross-linking agents, chain terminators, plasticizers, etc., prior to treatment with the alkylene imine. The treated copolymers are particularly useful in the formation of contact lenses for the application of medicinals to the eye, and for other depot materials.