Patents by Inventor Izrail Tsals
Izrail Tsals has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6641565Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: GrantFiled: November 12, 1999Date of Patent: November 4, 2003Assignee: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Yigal, Izrail Tsals, Joseph Gross
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Patent number: 6595956Abstract: A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocate chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to The device may also be provided with manually control for delivering a bolus dose of drug when necessary.Type: GrantFiled: March 23, 1999Date of Patent: July 22, 2003Inventors: Joseph Gross, Izrail Tsals, Gilad Lavi, Gil Yigal, Ehoud Carmel
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Publication number: 20030135159Abstract: A drug delivery device having a housing having an internal reservoir in communication with a drug delivery outlet via a fluid path. An expandable chamber disposed adjacent to the reservoir forces drug from the reservoir to the outlet when supplied with a gas. A flow regulating chamber, in communication with the fluid path, is capable of volumetric changes in response to temperature and/or pressure changes. An increase in the volume of the flow regulating chamber increases flow resistance to the outlet and thereby counteracts the corresponding increase in delivery rate resulting from the expansion of the expandable chamber due to the same volumetric changes in response to temperature and/or pressure. In a preferred embodiment, an electrical circuit has a current stabilizing element in electrical communication with an electrolytic cell which supplies the gas. A throttling device maintains a higher pressure in the device to reduce possible clogging of the fluid path.Type: ApplicationFiled: January 3, 2003Publication date: July 17, 2003Applicant: Elan Pharma International LimitedInventors: David Daily, Oz Cabiri, Mario Rozanowich, Miki Sahar, Jacob Stern, Diana Davidson, Izrail Tsals, Gilad Lavi, Avi Azoulay, Eran Shor, Craig Brodeur
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Patent number: 6585707Abstract: A system adapted to be disposed between a rigid or semi-rigid device and human skin for reliably attaching the device to the skin for an extended period of time. The system includes a skin-contacting surface for adhering to human skin, and an opposed surface for attachment to a rigid or semi-rigid device. The system is attached along its opposed surface to a portion of the total area of the adjacent surface of the device. When the device is subjected to external stress, the stress is transmitted through the area of attachment and distributed to the unattached area. This minimises stress on the skin and reduces the chance of detachment from the skin.Type: GrantFiled: May 20, 1999Date of Patent: July 1, 2003Assignee: Elan Pharma International LimitedInventors: Oz Cabiri, David Katz, Mario Rozanowich, Haim Danon, Joseph Gross, Izrail Tsals, Craig Brodeur, Robert Etheredge
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Publication number: 20030105430Abstract: An injector is automatic in that the needle is injected automatically into the injection site (e.g., a patient's skin), delivery is initiated upon activation of the injector, and the needle is retracted after the end of delivery. Preferably the needle is not seen by the user prior to, during or after injection. Prior and to and after injection, the needle is withdrawn into the device so as to avoid any potential injury or health risk to the user or health care provider. The injector includes a housing and a control unit arranged to slide within the housing to move a piston rod during drug delivery and to pivot within the housing for needle retraction. The injector may also include a back rod that moves the piston rod before activation of the injector for titration and reconstitution and automatically disengages from the piston rod upon activation of the injector. A needle-locking device can be used in any number of pen-like injectors or other types of injectors or syringes.Type: ApplicationFiled: November 8, 2002Publication date: June 5, 2003Applicant: ELAN PHARMA INTERNATIONAL LIMITED WIL HOUSEInventors: Gilad Lavi, Gil Yigal, Izrail Tsals
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Publication number: 20030097098Abstract: A needle assembly has a needle holder that holds a needle and a sheath. The sheath has a needle compartment that accommodates the needle and any spilled drug flowing from the needle. The sheath and the needle holders are detachable. The sheath has an opening communicating with the needle compartment. A liquid barrier, which can comprise a hydrophobic membrane, is positioned in the first opening, blocking the first opening. The liquid barrier allows gas to escape through the first opening but prevent liquid from leaking through the first opening during drug filling stage. In use, the sheath is positioned over the needle of a drug delivery device. The drug delivery device is filled through a separate port until its drug reservoir is completely filled, which is accomplished by filling until the drug spills out through the needle. The sheath maintains the spilled drug within the needle compartment, while air bubbles escape through the liquid barrier.Type: ApplicationFiled: March 21, 2001Publication date: May 22, 2003Inventors: Gilad Lavi, Ehoud Carmel, Izrail Tsals
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Patent number: 6530900Abstract: A drug delivery device having a housing having an internal reservoir in communication with a drug delivery outlet via a fluid path. An expandable chamber disposed adjacent to the reservoir forces drug from the reservoir to the outlet when supplied with a gas. A flow regulating chamber, in communication with the fluid path, is capable of volumetric changes in response to temperature and/or pressure changes. An increase in the volume of the flow regulating chamber increases flow resistance to the outlet and thereby counteracts the corresponding increase in delivery rate resulting from the expansion of the expandable chamber due to the same volumetric changes in response to temperature and/or pressure. In a preferred embodiment, an electrical circuit has a current stabilizing element in electrical communication with an electrolytic cell which supplies the gas. A throttling device maintains a higher pressure in the device to reduce possible clogging of the fluid path.Type: GrantFiled: May 23, 2000Date of Patent: March 11, 2003Assignee: Elan Pharma International LimitedInventors: David Daily, Oz Cabiri, Mario Rozanowich, Miki Sahar, Jacob Stern, Diana Davidson, Izrail Tsals, Gilad Lavi, Avi Azoulay, Eran Shor, Craig Brodeur
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Patent number: 6520941Abstract: A stopper for use in preventing any volume of gas from escaping from a drug container when used in connection therewith. The stopper has a body having a perimeter for slidable engagement with the interior of a drug receptacle; an outer surface; and an inner surface facing the bottom of the drug receptacle, the inner surface shaped so as to trap any volume of gas located within the drug receptacle when the body is slidably engaged therein. The invention is further directed to a drug container having a hollow body for holding a liquid. The body has an open end and a closed end. The container also has a stopper slidably received in the hollow body, and a feature for entrapping any volume of gas within the container.Type: GrantFiled: October 12, 1999Date of Patent: February 18, 2003Inventors: Kevin Durand, Izrail Tsals, Craig Brodeur
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Patent number: 6500150Abstract: A drug delivery device having a base member defining a skin-contacting surface, a syringe serving as a reservoir for the drug, and means for expelling drug from the syringe. The syringe is connected to the base member such that the longitudinal axis of the syringe is substantially parallel to the skin surface. A delivery needle is in communication with the syringe. The needle has an angled bend which directs the tip of the needle substantially perpendicular to the skin-contacting surface. In use, the tip of the needle is adapted to penetrate the skin of the subject.Type: GrantFiled: June 23, 1998Date of Patent: December 31, 2002Assignee: Elan Pharma International LimitedInventors: Joseph Gross, Gilad Lavi, Izrail Tsals
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Patent number: 6478771Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: GrantFiled: November 12, 1999Date of Patent: November 12, 2002Assignee: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Yigal, Izrail Tsals, Joseph Gross
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Publication number: 20020123719Abstract: The present invention related to a drug delivery device for mixing and delivering a drug by injection. The devices includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example, a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: ApplicationFiled: February 7, 2002Publication date: September 5, 2002Applicant: ELAN PHARMA INTERNATIONAL LIMITEDInventors: Gilad Lavi, Gil Ygal, Izrail Tsals, Joseph Gross
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Publication number: 20020055711Abstract: A needle device has a needle retraction mechanism that retracts the needle upon removing the device from the skin surface (either intentionally or unintentionally). Once the needle is retracted, the device is rendered inoperative. The needle can be further made inoperative by bending it when one attempts to reuse the device. In another embodiment, a needle opening formed in the base of the housing can be covered to render the needle inoperative when one attempts to reuse the device. In another embodiment, the needle device instead has a needle shield that automatically covers the needle after use.Type: ApplicationFiled: June 17, 2001Publication date: May 9, 2002Inventors: Gilad Lavi, Gil Yigal, Izrail Tsals
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Patent number: 6364865Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle s used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: GrantFiled: November 12, 1999Date of Patent: April 2, 2002Assignee: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Yigal, Izrail Tsals, Joseph Gross
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Publication number: 20020007671Abstract: A device for measuring a volume of liquid drug. The device includes a first chamber containing liquid drug, a measurement chamber in liquid communication with the first chamber, and a measurement assembly.Type: ApplicationFiled: March 20, 2001Publication date: January 24, 2002Inventors: Gilad Lavi, Gil Yigal, Izrail Tsals
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Publication number: 20020010423Abstract: A drug delivery device having a base member defining a skin-contacting surface, a syringe serving as a reservoir for the drug, and means for expelling drug from the syringe. The syringe is connected to the base member such that the longitudinal axis of the syringe is substantially parallel to the skin surface. A delivery needle is in communication with the syringe. The needle has an angled bend which directs the tip of the needle substantially perpendicular to the skin-contacting surface. In use, the tip of the needle is adapted to penetrate the skin of the subject.Type: ApplicationFiled: April 17, 2001Publication date: January 24, 2002Applicant: Elan Corporation plcInventors: Joseph Gross, Gilad Lavi, Izrail Tsals
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Publication number: 20020004643Abstract: A spike for facilitating the introduction of liquid under pressure into a container containing a substance is provided which includes an elongate spike shaft having a spike side wall, a longitudinal axis, a distal end and a proximally located end portion, where the distal end has a sharp, pointed tip. An introduction channel is located within the spike shaft for receiving liquid into the container where a portion of the introduction channel is angled to cause liquid to travel out of the introduction channel in a direction non-parallel to the longitudinal axis of the spike shaft. An extraction channel may be included within the spike shaft for removing liquid from the container, where the extraction channel extends through the elongate spike shaft towards the proximally located end portion.Type: ApplicationFiled: May 23, 2001Publication date: January 10, 2002Inventors: Ehoud Carmel, Gilad Lavi, Gil Yigal, Izrail Tsals
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Publication number: 20010056262Abstract: A system adapted to be disposed between a rigid or semi-rigid device and human skin for reliably attaching the device to the skin for an extended period of time. The system includes a skin-contacting surface for adhering to human skin, and an opposed surface for attachment to a rigid or semi-rigid device. The system is attached along its opposed surface to a portion of the total area of the adjacent surface of the device. When the device is subjected to external stress, the stress is transmitted through the area of attachment and distributed to the unattached area. This minimises stress on the skin and reduces the chance of detachment from the skin.Type: ApplicationFiled: May 20, 1999Publication date: December 27, 2001Inventors: OZ CABIRI, DAVID KATZ, MARIO ROZANOWICH, HAIM DANON, JOSEPH GROSS, IZRAIL TSALS, CRAIG BRODEUR, ROBERT ETHEREDGE
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Publication number: 20010025168Abstract: A drug delivery device having a base member defining a skin-contacting surface, a syringe serving as a reservoir for the drug, and means for expelling drug from the syringe. The syringe is connected to the base member such that the longitudinal axis of the syringe is substantially parallel to the skin surface. A delivery needle is in communication with the syringe. The needle has an angled bend which directs the tip of the needle substantially perpendicular to the skin-contacting surface. In use, the tip of the needle is adapted to penetrate the skin of the subject.Type: ApplicationFiled: April 18, 2001Publication date: September 27, 2001Applicant: Elan Corporation plcInventors: Joseph Gross, Gilad Lavi, Izrail Tsals
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Patent number: D437930Type: GrantFiled: May 13, 1999Date of Patent: February 20, 2001Assignee: Elan Corporation, plcInventors: Joseph Gross, Gilad Lavi, Izrail Tsals, Gil Yigal
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Patent number: D455207Type: GrantFiled: May 13, 1999Date of Patent: April 2, 2002Assignee: Elan Corporation, plcInventors: Joseph Gross, Gilad Lavi, Izrail Tsals, Gil Yigal