Patents by Inventor J. Alex BATES

J. Alex BATES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS
    Publication number: 20210163465
    Abstract: Disclosed are compounds of Formula (I) to (VIII): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.
    Type: Application
    Filed: December 16, 2020
    Publication date: June 3, 2021
    Inventors: Xiaojun Zhang, Eldon Scott Priestley, J. Alex Bates, Oz Scott Halpern, Samuel Kaye Reznik, Jeremy M. Richter
  • 3-sulfonyl-5-aminopyridine-2,4-diol APJ agonists
    Patent number: 10669258
    Abstract: The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: June 2, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jeremy M. Richter, J. Alex Bates
  • 3-SULFONYL-5-AMINOPYRIDINE-2,4-DIOL APJ AGONISTS
    Publication number: 20190308948
    Abstract: The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
    Type: Application
    Filed: October 12, 2017
    Publication date: October 10, 2019
    Inventors: Jeremy M. Richter, J. Alex Bates
  • BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS
    Publication number: 20190292176
    Abstract: Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.
    Type: Application
    Filed: July 13, 2017
    Publication date: September 26, 2019
    Inventors: Xiaojun Zhang, Eldon Scott Priestley, J. Alex Bates, Oz Scott Halpern, Samuel Kaye Reznik, Jeremy M. Richter
  • Macrocyclic factor VIIa inhibitors
    Patent number: 9657006
    Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: May 23, 2017
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Jeremy Richter, J. Alex Bates, Daniel L. Cheney
  • MACROCYCLIC FACTOR VIIA INHIBITORS
    Publication number: 20160115159
    Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.
    Type: Application
    Filed: June 11, 2014
    Publication date: April 28, 2016
    Inventors: Jeremy RICHTER, J. Alex BATES, Daniel L. CHENEY