Abstract: Known reactions are arranged in a novel manner to produce 11.beta.-difluoromethyl and (E)- and (Z)-11-fluoromethylene 19-norandrostenediones and 19-nor-13.beta.-ethylandrostenediones which are useful as contraceptive agents.

Abstract: 17.beta.-Difluoromethyl steroids are disclosed which have progestational, antiprogestational activity and which are useful as and male and female contraceptive agents.

Abstract: The steroids of the present invention have been found to be useful as male contraceptives when administered orally. Upon cessation of administration of the male contraceptive steroids of the present invention the male promptly regains normal fertility.

Abstract: Novel steroid derivatives containing a tyrosine ester amide group linked to an 11-hydroxysteroid alkylene dicarboxylic hemi-ester are described, suitable for iodination with radioactive iodine, useful in radioimmunoassay.

Abstract: A process for the prevention or treatment of osteoporosis induced as a side effect of the administration of glucocorticoid steroids by the administration of a compound of the formula: ##STR1## WHEREIN R.sub.1 and R.sub. 2 are the same or different radicals selected from the group consisting of hydrogen, alkyl of less than 9 carbon atoms, and phenyl; R.sub.3 and R.sub. 5 are selected from the group consisting of hydrogen and lower acyl; n is an integer, selected from the group consisting of 2, 3, and 4; or a hydrate thereof in association with a pharmaceutical carrier to a human or animal being treated or having been treated with a gluco-corticoid hormone.

Abstract: Novel testosterone 17-ether 2,3-isoxazole and 2-cyano derivatives are disclosed as useful steroid enzyme inhibitors and for other pharmaceutical purposes.