Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: A lock assembly for a door includes a lock body for mounting above a door lever of the door and including a locking bolt supported in a housing of the lock body for movement between a retracted position and an extended position. The locking bolt is held in the retracted position and spring biased toward the extended position and releasable from the retracted position to move to the extended position in response to actuation of a trigger operatively coupled with the lock body. The lock assembly further includes a door lever assembly adapted for mounting on the door lever in rotative fixed relationship with the door lever, and operatively coupled with the locking bolt so that rotation of the door lever assembly causes movement of the locking bolt from the extended position to the retracted position.

Abstract: The present disclosure relates to methods of treating or preventing a sleep breathing disorder. More specifically, the disclosure relates to a method of treating or preventing sleep apnea comprising the use of a KCNQ potassium channel opener.

Abstract: A pipe coupling for connecting adjacent pipes. The pipe coupling has a connection type at each end that may be male or female. A female end may have an interior surface defining a receiving chamber. An interior circumferential groove is formed in the interior surface in which a band is seated. A plurality of rigid fingers is extends from the band into the receiving chamber. The receiving chamber receives a male end of an adjacent pipe, the male end having an exterior surface. An exterior circumferential groove is defined on the exterior surface to receive the plurality of rigid fingers. A variety of connection types and combinations are disclosed. The female end may define a sight window to permit viewing of the position of a male end of an adjacent pipe. The receiving chamber may have a reduced diameter proximate to the middle of the coupling to improve sealing.

Abstract: An example of a thermal composite includes a substrate, a primer layer, a first adhesive layer, a blanket layer, a second adhesive layer, and a metal layer. The blanket layer includes basalt fibers or glass fibers. The thermal composite may be incorporated into a battery pack as a battery enclosure.

Abstract: Methods of repairing a defect in a polymeric composite structure are provided. The methods include disposing a patch over a defect in a polymeric composite structure; disposing a textured sheet over the polymeric patch, applying pressure to the polymeric patch and the textured sheet; and heating the polymeric patch. The textured sheet has a surface texture that is a negative of a surface texture of the polymeric composite structure.

Abstract: A pipe coupling for connecting adjacent pipes. The pipe coupling has a connection type at each end that may be male or female. A female end may have an interior surface defining a receiving chamber. An interior circumferential groove is formed in the interior surface in which a band is seated. A plurality of rigid fingers is extends from the band into the receiving chamber. The receiving chamber receives a male end of an adjacent pipe, the male end having an exterior surface. An exterior circumferential groove is defined on the exterior surface to receive the plurality of rigid fingers. A variety of connection types and combinations are disclosed. The female end may define a sight window to permit viewing of the position of a male end of an adjacent pipe. The receiving chamber may have a reduced diameter proximate to the middle of the coupling to improve sealing.

Abstract: A lock assembly for a door includes a lock body for mounting above a door lever of the door and including a locking bolt supported in a housing of the lock body for movement between a retracted position and an extended position. The locking bolt is held in the retracted position and spring biased toward the extended position and releasable from the retracted position to move to the extended position in response to actuation of a trigger operatively coupled with the lock body. The lock assembly further includes a door lever assembly adapted for mounting on the door lever in rotative fixed relationship with the door lever, and operatively coupled with the locking bolt so that rotation of the door lever assembly causes movement of the locking bolt from the extended position to the retracted position.

Abstract: Examples of an application experiment system are provided that can manage and run experiments for software applications. In one embodiment, the application experiment system receives definitions for experiments and treatments for an application, runs experiments in response to requests from users of the system, automatically allocates treatments to users of the application, logs experiment data and treatment allocation data, and/or reports experiment results data. The application experiment system enables application developers to test changes or features in a precise, controlled environment on a limited user base before deciding whether to deploy changes or features to all users of an application.

Abstract: A method for fabricating a micro-truss structure having particular application for a vehicle impact structure. The method includes providing a thin support enclosure having a plurality of walls, where at least one of the walls is transparent to ultraviolet (UV) light. The support enclosure is filled with a liquid photomonomer resin and light from at least one UV source is directed through apertures in a mask and through the at least one transparent wall into the enclosure so as to polymerize and at least partially cure columns of the resin therein to form polymerized struts defining a micro-truss core in the enclosure that is secured to the walls. The support enclosure is then inserted into an outer structural enclosure.

Abstract: A three-dimensional lattice includes a stabilizing grid having grid warp strands and grid weft strands crossing the grid warp strands. Grid cells are defined by adjacent grid warp strands and adjacent grid weft strands intersecting the adjacent grid warp strands. A projecting net has net warp strands and net weft strands crossing the net warp strands. Each subnet in a plurality of subnets uniquely corresponds to a corresponding grid cell. Each subnet includes a net warp strand portion intersecting both of the grid weft strands that define the corresponding grid cell. Each subnet includes a net weft strand portion intersecting both of the grid warp strands that define the corresponding grid cell. The net warp strand portion and the net weft strand portion of each subnet are spaced from a minimum surface defined by the corresponding grid cell.

Abstract: Adhesive bonds may be formed between components (e.g., automotive) by sliding components into position without wiping or removing the uncured adhesive. Here, a first bonding region has an uncured adhesive and a plurality of bond standoffs that is positioned adjacent to a second bonding region. Bond standoffs promote sliding between the first and second components, while substantially retaining the uncured adhesive during the sliding. Bond standoffs can be formed on the surface, for example, by molding or stamping. The first and second bonding regions slide into engagement, followed by applying pressure, heat, and/or energy as needed, to form a solid adhesive bond. Methods of repairing manufactured components (e.g., automotive) are also provided with such techniques, including the ability to slide parts into place without removing the uncured adhesive, using bond standoffs formed as strips of adhesive cured on the substrate component or tacks pinned into a composite substrate component.

Abstract: The present disclosure relates generally to a method of multiple attribute monitoring for biological and other complex compounds using a chromatography-optical detector-mass spectrometry method. The mass spectrometry method can use a high resolution mass spectrometer. The methodology utilizes similar analytical techniques and instruments for both the characterization and the monitoring of biological and other complex compounds.

Abstract: A process for fabricating a curved vehicle impact sandwich beam including a micro-truss structure. The method includes positioning a mold in contact with a curved bottom facesheet so that the mold and the bottom facesheet define a reservoir. The reservoir is filled with a liquid photo-polymer resin and a mask is positioned over the reservoir. A series of UV light sources are provided on a mounting member relative to the mask and the mounting member is flexed to conform to the shape of the bottom facesheet. Light from UV sources shines through apertures in the mask to cure and form polymerized struts in the reservoir to define the micro-truss structure formed to the facesheet.

Abstract: An example of a thermal composite includes a substrate, a primer layer, a first adhesive layer, a blanket layer, a second adhesive layer, and a metal layer. The blanket layer includes basalt fibers or glass fibers. The thermal composite may be incorporated into a battery pack as a battery enclosure.

Abstract: Methods of repairing a defect in a polymeric composite structure are provided. The methods include disposing a patch over a defect in a polymeric composite structure; disposing a textured sheet over the polymeric patch, applying pressure to the polymeric patch and the textured sheet; and heating the polymeric patch. The textured sheet has a surface texture that is a negative of a surface texture of the polymeric composite structure.

Abstract: Examples of an application experiment system are provided that can manage and run experiments for software applications. In one embodiment, the application experiment system receives definitions for experiments and treatments for an application, runs experiments in response to requests from users of the system, automatically allocates treatments to users of the application, logs experiment data and treatment allocation data, and/or reports experiment results data. The application experiment system enables application developers to test changes or features in a precise, controlled environment on a limited user base before deciding whether to deploy changes or features to all users of an application.

Abstract: A process for fabricating a curved beam including a micro-truss structure. In one embodiment, the process includes fabricating the micro-truss structure on a bottom facesheet, where the micro-truss structure is only partially cured so that it is readily bendable, and then forming the partially cured micro-truss structure and bottom facesheet over a curved fixture, where the partially cured micro-truss structure is then fully cured and hardened to its final curved state. A top facesheet is then adhered to a top surface of the micro-truss structure. In an alternate embodiment, a curved bottom facesheet is forced flat against a fixture and the micro-truss structure is formed while the bottom facesheet is secured to the fixture to a partially cured state. The bottom facesheet is then released from the fixture, which causes it to return to its curved configuration causing the micro-truss structure to bend.

Abstract: Examples of an application experiment system are provided that can manage and run experiments for software applications. In one embodiment, the application experiment system receives definitions for experiments and treatments for an application, runs experiments in response to requests from users of the system, automatically allocates treatments to users of the application, logs experiment data and treatment allocation data, and/or reports experiment results data. The application experiment system enables application developers to test changes or features in a precise, controlled environment on a limited user base before deciding whether to deploy changes or features to all users of an application.

Abstract: A system for monitoring for gas and oil flow venting from a surface using time intervals, size and velocity, and using an analysis processor with a data storage containing a bubble flow classification and bubble flow categories. The data storage receives at least one of: video feed, logging while drilling data feed, seismic profile data feed, drilling parameter data feed, measurement while drilling data feed, sonar data feed, hydrographic data feed and a laser data feed to verify a determined bubble flow category and bubble flow classification as a baseline bubble flow classification and provides an alarm when a bubble flow emergency is ascertained due to a change in bubble flow classification without an anticipated change or changes outside predefined acceptable limits within the video feed, logging while drilling data feed, seismic profile data feed, drilling parameter data feed, measurement while drilling data feed, sonar data feed, hydrographic data feed and a laser data feed.