Abstract: A dedicated access module inserted between standard conveyor belt modules in a conveyor belt forms a dedicated opening and closing point for the conveyor belt. The dedicated access module comprises two mating portions, each portion including standard, articulating hinge elements on an outside end and non-articulating connection means on an inside end for connecting to the other, corresponding mating portion.

Abstract: Disclosed are compounds of formula (I): and pharmaceutically acceptable salts thereof. The compounds of the invention are BDII-selective inhibitors of BET proteins, and have therapeutic potential for treating cancer, acute kidney disease, and viral infections, among other diseases.

Abstract: The present disclosure provides compounds and compositions thereof which are useful as inhibitors of tyrosine kinase and which exhibit desirable characteristics for the same. Further disclosed herein are methods of treating cancer using these tyrosine kinase inhibitor compounds.

Abstract: Systems and methods are disclosed for pressure-sensitive, electrophoretic displays, which may optionally include haptic feedback. A display may comprise a first conductive layer having a pressure-sensitive conductivity and an electrophoretic layer positioned adjacent to the first conductive layer, wherein the electrophoretic layer is in electrical communication with the first conductive layer and is configured to locally change state based on a pressure applied to the first conductive layer. Local and global writing and erasing of the display can also be achieved.

Abstract: A photonics package may include a substrate, a hanging connector, and a fast-axis collimator (“FAC”). The hanging connector is typically affixed to a side of the substrate other than the side through which a light output is emitted. The hanging connector may be L-shaped in cross-section, having a base section and an extended section projecting from the base section. The base section affixes to the substrate while the extended section affixes to the FAC, so that the FAC extends downward along the emitter surface of the substrate; a vertex of the FAC is coplanar with an emitter outputting the light output.

Abstract: A dedicated access module inserted between standard conveyor belt modules in a conveyor belt forms a dedicated opening and closing point for the conveyor belt. The dedicated access module comprises two mating portions, each portion including standard, articulating hinge elements on an outside end and non-articulating connection means on an inside end for connecting to the other, corresponding mating portion.

Abstract: Improved methods for driving an active matrix of pixel electrodes controlled with thin film transistors when the voltage on a top electrode is being altered between driving frames. The method is useful for electrowetting devices. In particular, the methods can provide for more consistent droplet movement when used with a digital microfluidic device based upon an active matrix of pixel electrodes.

Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.

Abstract: Disclosed are compounds of formula (I): and pharmaceutically acceptable salts thereof. The compounds of the invention are BDII-selective inhibitors of BET proteins, and have therapeutic potential for treating cancer, acute kidney disease, and viral infections, among other diseases.

Abstract: Disclosed is a staged-air burner device capable of high energy efficiency, high flame stability, combusting multiple readily switchable fuels ranging from pure hydrogen, to any hydrogen/methane mixture, to pure methane, and generating a low level of NOx. The burner device can include: a primary air chamber receiving a primary air and a flue gas; a burner tube capable of receiving a fuel jet and drawing in the air-flue gas mixture from the primary air chamber; a burner tip discharging the fuel-air-flue gas mixture formed in the burner tube to a first combustion zone and a second combustion zone via center orifices and side orifices on the burner tip, respectively; and a staged air chamber receiving staged air and discharging it via staged air ports into a third combustion zone. Combustion of the fuel occurs in at least one of the first, second, and third combustion zones.

Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.

Abstract: Described herein are one or more methods for integrating an optical component into an integrated photonics device. The die including a light source, an outcoupler, or both, may be bonded to a wafer having a cavity. The die can be encapsulated using an insulating material, such as an overmold, that surrounds its edges. Another (or the same) insulating material can surround conductive posts. Portions of the die, the overmold, and optionally, the conductive posts can be removed using a grinding and polishing process to create a planar top surface. The planar top surface enables flip-chip bonding and an improved connection to a heat sink. The process can continue with forming one or more additional conductive layers and/or insulating layers and electrically connecting the p-side and n-side contacts of the laser to a source.

Abstract: A photonics package may include a substrate, a hanging connector, and a fast-axis collimator (“FAC”). The hanging connector is typically affixed to a side of the substrate other than the side through which a light output is emitted. The hanging connector may be L-shaped in cross-section, having a base section and an extended section projecting from the base section. The base section affixes to the substrate while the extended section affixes to the FAC, so that the FAC extends downward along the emitter surface of the substrate; a vertex of the FAC is coplanar with an emitter outputting the light output.

Abstract: Methods and systems for driving an active matrix electrowetting on dielectric device including thin-film-transistors to increase the switching frequency of the propulsion electrodes beyond what is typical for line-by-line active matrix driving. By using a latching circuit, it is possible to selectively switch specific propulsion (pixel) electrodes between an “on” and an “off” state, wherein a propulsion electrode in an “on” state can be driven by a time varying drive voltage on the top electrode that is a much higher frequency than is typically possible with amorphous silicon thin-film-transistor arrays. The faster drive frequency improves the performance of electrowetting devices, especially when used with aqueous droplets having a high ionic strength.

Abstract: Improved methods for driving an active matrix of pixel electrodes controlled with thin film transistors when the voltage on a top electrode is being altered between driving frames. The methods described increase performance by providing smaller swings in the overall voltage between the top electrode and pixel electrode while reducing stress on the thin film transistor.

Abstract: Described herein is an integrated photonics device including a light emitter, integrated edge outcoupler(s), optics, and a detector array. The device can include a hermetically sealed enclosure. The hermetic seal can reduce the amount of moisture and/or contamination that may affect the measurement, analysis, and/or the function of the individual components within the sealed enclosure. Additionally or alternatively, the hermetic seal can be used to protect the components within the enclosure from environmental contamination induced during the manufacturing, packaging, and/or shipping process. The outcoupler(s) can be formed by creating one or more pockets in the layers of a die. Outcoupler material can be formed in the pocket and, optionally, subsequent layers can be deposited on top. The edge of the die can be polished until a targeted polish plane is achieved. Once the outcoupler is formed, the die can be flipped over and other components can be formed.

Abstract: A photonics package may include a substrate, a hanging connector, and a fast-axis collimator (“FAC”). The hanging connector is typically affixed to a side of the substrate other than the side through which a light output is emitted. The hanging connector may be L-shaped in cross-section, having a base section and an extended section projecting from the base section. The base section affixes to the substrate while the extended section affixes to the FAC, so that the FAC extends downward along the emitter surface of the substrate; a vertex of the FAC is coplanar with an emitter outputting the light output.

Abstract: A woven structure formed by warp and weft tows A, E of fiber reinforcement material includes: a plurality of multi-warp stacks SA, each including a plurality of warp tows A which are in superposition along a longitudinal extent of the warp stack SA, a plurality of multi-weft stacks SE, each including a plurality of weft tows E which are in superposition along the stack SE, wherein one or more multi-warp stacks SA and/or one or more multi-weft stacks SE has an embedded taper structure, including: an embedded tow A1, A2, E1, E2 which has a terminal portion M1, M2 disposed between two locally outermost tows A0, E0 of the respective stack SA SE, the terminal portion M1, M2 terminating at a taper position D1 D2 along the respective path of the stack SA SE; and a method for manufacturing a composite component.

Abstract: A magneto-electrophoretic medium that can be globally and locally addressed and erased. The medium provides a writeable display with no perceivable lag and the ability to write and erase with only minimal power requirements. In particular, the magneto-electrophoretic medium can be erased by providing a subthreshold electric stimulus and supplementing a second non-electric stimulus that disturbs the written state and allows the magneto-electrophoretic particles to return to their original state.

Abstract: Described herein are one or more methods for integrating an optical component into an integrated photonics device. The die including a light source, an outcoupler, or both, may be bonded to a wafer having a cavity. The die can be encapsulated using an insulating material, such as an overmold, that surrounds its edges. Another (or the same) insulating material can surround conductive posts. Portions of the die, the overmold, and optionally, the conductive posts can be removed using a grinding and polishing process to create a planar top surface. The planar top surface enables flip-chip bonding and an improved connection to a heat sink. The process can continue with forming one or more additional conductive layers and/or insulating layers and electrically connecting the p-side and n-side contacts of the laser to a source.