Abstract: The disclosure relates to methods for treating pemphigus and/or a pemphigoid disease in a subject in need thereof, wherein the methods include administering to a subject in need thereof a therapeutically effective amount of an FcRn inhibitor. In certain embodiments, the FcRn inhibitor is an anti-FcRn antibody or antigen-binding fragment thereof.

Abstract: An orientation of an application user interface (e.g., text and/or content) on a display of a device may be determined by an orientation of the device relative to gravity. In situations where the orientation of the device relative to gravity does not provide a confident or accurate orientation for the application user interface, orientation of the application user interface may be determined from face orientation data. Face orientation data may be obtained from a face detection process operating on images of the user captured during a facial recognition process or during an attention detection process.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to human serum albumin. The FcRn-binding proteins can be used to treat a variety of disorders including acute and chronic toxic exposure.

Abstract: A gas management system for use with an ostomy pouch includes an insert port defining an insert-receiving passage in communication with an inner chamber of an ostomy pouch and an exterior of the ostomy pouch. The insert port may be integrated into one or more walls of the ostomy pouch. An insert is selectively received in the insert-receiving passage of the insert port, the insert including at least one vent therein. An odor absorbent element is disposed in the insert. The insert-receiving passage and the vent of the insert defining a pathway for gases passing from the inner chamber of the ostomy pouch and through the absorbent material to pass out of the gas management apparatus. A guard may be supplied to carry a used insert upon removal from the insert port, as well as a replacement insert. The guard may have a wall to seal the used insert and the replacement insert. In certain embodiments, an applicator may be used to facilitate insertion of replacement inserts.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract: A gas management system for use with an ostomy pouch includes an insert port defining an insert-receiving passage in communication with an inner chamber of an ostomy pouch and an exterior of the ostomy pouch. The insert port may be integrated into one or more walls of the ostomy pouch. An insert is selectively received in the insert-receiving passage of the insert port, the insert including at least one vent therein. An odor adsorbent element is disposed in the insert. The insert-receiving passage and the vent of the insert defining a pathway for gases passing from the inner chamber of the ostomy pouch and through the adsorbent material to pass out of the gas management apparatus. A guard may be supplied to carry a used insert upon removal from the insert port, as well as a replacement insert. The guard may have a wall to seal the used insert and the replacement insert. In certain embodiments, an applicator may be used to facilitate insertion of replacement inserts.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract: An orientation of an application user interface (e.g., text and/or content) on a display of a device may be determined by an orientation of the device relative to gravity. In situations where the orientation of the device relative to gravity does not provide a confident or accurate orientation for the application user interface, orientation of the application user interface may be determined from face orientation data. Face orientation data may be obtained from a face detection process operating on images of the user captured during a facial recognition process or during an attention detection process.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to human serum albumin. The FcRn-binding proteins can be used to treat a variety of disorders including acute and chronic toxic exposure.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract: A gas management system for use with an ostomy pouch includes an insert port defining an insert-receiving passage in communication with an inner chamber of an ostomy pouch and an exterior of the ostomy pouch. The insert port may be integrated into one or more walls of the ostomy pouch. An insert is selectively received in the insert-receiving passage of the insert port, the insert including at least one vent therein. An odor adsorbent element is disposed in the insert. The insert-receiving passage and the vent of the insert defining a pathway for gases passing from the inner chamber of the ostomy pouch and through the adsorbent material to pass out of the gas management apparatus. A guard may be supplied to carry a used insert upon removal from the insert port, as well as a replacement insert. The guard may have a wall to seal the used insert and the replacement insert. In certain embodiments, an applicator may be used to facilitate insertion of replacement inserts.

Abstract: The invention relates to method and apparatus for relieving headaches. The method broadly comprises the step of applying a sufficient force to a given area of the triangular fossa region of the patient's ear for a sustained period of time effective for treating the patient by reducing the perceived pain of the headache. Apparatus is disclosed for employing the method, the apparatus comprising a banded earplug device having a biased headband positionable about the head of the patient and a pair of pods at opposite ends of the biased headband. The pods are placeable in compressive engagement with an area of the triangular fossa region in each of the patient's ears.

Abstract: In one embodiment, the digital bed system is comprised of an array of support cells. Each support cells is capable of communicating with a controller and increasing and decreasing in firmness in response to commands issued by a controller. The support cells are operatively connected to a communication channel that is also connected to a controller. The controller is capable of receiving data from the support cells and is also capable of issuing commands to each of the support cells. The controller is programmed issue commands to increase or decrease the firmness of individual support cells within the support cells.

Abstract: Disclosed is a swimming device which allows a swimmer to read while swimming. A support structure is configured to support reading material in the form of a book, newspaper, or electronic reading device. An attachment device is operatively connected to the support structure and rigidly connects the support structure to the swimmer's body.

Abstract: A vehicle includes a chassis supporting two front axle assemblies and two rear axle assemblies. Each of the front and rear axle assemblies includes an extendible and retractable axle supporting an independently steerable wheel and a steering mechanism. The axles of the respective front and rear axle assemblies are offset from each other. By providing independently steerable wheels, the vehicle is operable in a plurality of steering modes including two-wheel steer, crab steer and coordinated steer. A steering angle for each steering wheel is determined according to a steering angle of an inside front wheel on a turn-by-turn basis.

Abstract: A vehicle includes a chassis supporting two front axle assemblies and two rear axle assemblies. Each of the front and rear axle assemblies includes an extendible and retractable axle supporting an independently steerable wheel and a steering mechanism. The axles of the respective front and rear axle assemblies are offset from each other. By providing independently steerable wheels, the vehicle is operable in a plurality of steering modes including two-wheel steer, crab steer and coordinated steer. A steering angle for each steering wheel is determined according to a steering angle of an inside front wheel on a turn-by-turn basis.

Abstract: A method and apparatus for automating the process of confidentially determining whether people feel mutual attraction or have mutual interests and for automating the process of notifying the people involved of such a match in feelings or interests, while allowing anonymity if no mutual attraction or interests exist. A computer system receives inputs from various persons indicating the identities of persons for whom they feel attraction or with whom they share mutual interests. The system collects this information and periodically searches for matches, i.e., for mutual attractions or interests that have been entered into the system. No notification occurs unless the system determines that a match in attraction or interests exists. If a first person's feelings or interests are not mirrored by a second person, the system will not notify either person and only the computer system will be aware of the first person's feelings for the second person.

Abstract: A bidirectional input/output buffer is disclosed, where the receiver includes complementary bus keeper transistors. The keeper transistors are of opposite conductivity types, and have their gates coupled to the output of a receiver inverter. The keeper transistors thus reinforce the driven data state at the input of the receiver, in CMOS latch fashion, and hold the prior data state thereon after the driving output driver is in tristate. The keeper transistors have significantly weaker drive characteristics than the other receiver transistors, and than typical output drivers, so that the keeper transistors can be easily overdriven with the next data state, if different. In addition, the source/drain resistance of the keeper transistors is also preferably quite high, so that the power dissipation on switching is relatively low. These characteristics are readily achievable by providing relatively long channel lengths for the keeper transistors, relative to other transistors in the circuit.

Abstract: Disclosed is the addition of passive feedback to a prior art T.sup.2 L circuit. The T.sup.2 L circuit with feedback, in accordance with the invention, has a lower power dissipation while retaining noise immunity and small gate delay. The additional resistor required for the feedback T.sup.2 L circuit, in accordance with the invention, can be incorporated into the T.sup.2 L cell without increasing the cell size. The feedback T.sup.2 L circuit, in accordance with the invention, lends itself to the addition of an integrated direct-coupled inverter (DCI) function. The feedback T.sup.2 L circuit, in accordance with the invention, permits more function to be placed on an integrated circuit semiconductor chip while maintaining gate performance and adherence to power restrictions.