Patents by Inventor J. Bruce German

J. Bruce German has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bovine milk oligosaccharides
    Patent number: 10238674
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: March 26, 2019
    Assignee: The Regents of the University of California
    Inventors: J. Bruce German, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
  • Enzymes And Methods For Cleaving N-Glycans From Glycoproteins
    Publication number: 20190054155
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Application
    Filed: August 8, 2018
    Publication date: February 21, 2019
    Inventors: Daniel GARRIDO, J. Bruce GERMAN, Carlito B. LEBRILLA, David A. MILLS
  • Methods of producing glycolipids
    Patent number: 10196663
    Abstract: Provided are methods and yeast cultures for producing glycolipids and glycolipid compositions.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: February 5, 2019
    Assignee: The Regents of the University of California
    Inventors: Kyria Boundy-Mills, Luis Antonio Garay Almada, Irnayuli Sitepu, J. Bruce German
  • Methods and compositions for improved digestion of milk oligosaccharides
    Patent number: 10165788
    Abstract: Pre-biotic compositions containing oligosaccharides and probiotic compositions useful for treatment of a subject are provided herein. Also provided are methods for administering probiotic or pre-biotic compositions.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: January 1, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: David Mills, Daniel Garrido, Santiago Ruiz-Moyano, Carlito Lebrilla, J. Bruce German
  • Enzymes and methods for cleaving N-glycans from glycoproteins
    Patent number: 10071142
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: September 11, 2018
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • BOVINE MILK OLIGOSACCHARIDES
    Publication number: 20170326164
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Application
    Filed: July 20, 2017
    Publication date: November 16, 2017
    Inventors: J. Bruce German, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
  • Bovine milk oligosaccharides
    Patent number: 9808475
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 7, 2017
    Assignee: The Regents of the University of California
    Inventors: J. Bruce German, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
  • ANTIBACTERIAL AND PROTECTIVE FORMULATIONS AND METHODS FOR MAKING AND USING THEM
    Publication number: 20170312322
    Abstract: Provided are compositions and methods for treating, ameliorating and preventing various infections, disorders and conditions in mammals, including genetically-predisposed and chronic disorders, where a microbial or bacterial flora is at least one causative or symptom-producing factor, where exemplary compositions are products of manufacture, a food, a drink, a nutraceutical, a dietary supplement, a formulation, a pharmaceutical or a pharmaceutical preparation comprising at least one or several of a plurality of isolated, or substantially purified bacteriophages or prophages, or bacteriophage subunits, a milk, a milk product, milk lipid, C milk fat globule (MFG) macromolecule, a milk mucin, a milk glycolipid, a milk free glycan, a milk mucin-like glycoprotein, a milk protein, a milk sugar or lactose, a milk fat or butterfat, a milk vitamin.
    Type: Application
    Filed: November 18, 2015
    Publication date: November 2, 2017
    Inventors: Forest ROHWER, Jeremy J. BARR, J. Bruce GERMAN
  • METHODS OF PRODUCING GLYCOLIPIDS
    Publication number: 20170183702
    Abstract: Provided are methods and yeast cultures for producing glycolipids and glycolipid compositions.
    Type: Application
    Filed: March 30, 2015
    Publication date: June 29, 2017
    Applicant: The Regents of the University of California
    Inventors: Kyria BOUNDY-MILLS, Luis Antonio GARAY ALMADA, Irnayuli SITEPU, J. Bruce GERMAN
  • PREBIOTIC OLIGOSACCHARIDES
    Publication number: 20170000811
    Abstract: The present invention provides galacto-oligosaccharide compositions that preferentially stimulate growth of specific Bifidobacterium species and subspecies.
    Type: Application
    Filed: July 22, 2016
    Publication date: January 5, 2017
    Inventors: Mariana Barboza, J. Bruce German, Carlito B. Lebrilla, David Mills, Samara Freeman-Sharkey, William Robert King
  • ENZYMES AND METHODS FOR CLEAVING N-GLYCANS FROM GLYCOPROTEINS
    Publication number: 20160287680
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Application
    Filed: March 24, 2016
    Publication date: October 6, 2016
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • BOVINE MILK OLIGOSACCHARIDES
    Publication number: 20160143928
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Application
    Filed: September 30, 2015
    Publication date: May 26, 2016
    Inventors: J. Bruce German, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
  • Enzymes and methods for cleaving N-glycans from glycoproteins
    Patent number: 9327016
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: May 3, 2016
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • Bovine milk oligosaccharides
    Patent number: 9200091
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: December 1, 2015
    Assignee: The Regents of the University of California
    Inventors: J. Bruce German, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
  • ENZYMES AND METHODS FOR CLEAVING N-GLYCANS FROM GLYCOPROTEINS
    Publication number: 20150110771
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Application
    Filed: February 14, 2013
    Publication date: April 23, 2015
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • Bifidobacterial gene sequences and their use
    Patent number: 8999705
    Abstract: This invention provides nucleic acids and proteins involved in oligosaccharide modification in the species Bifidobacteria. The invention provides methods for utilizing the proteins of the invention to generate human milk oligosaccharides or oligosaccharide mimics. The invention also provides compositions containing the human milk oligosaccharides or oligosaccharide mimics and methods for use.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: April 7, 2015
    Assignee: The Regents of the University of California
    Inventors: David A. Mills, Carlito B. Lebrilla, J. Bruce German, David Sela
  • Methods and Compositions for Improved Digestion of Milk Oligosaccharides
    Publication number: 20150010670
    Abstract: Pre-biotic compositions containing oligosaccharides and probiotic compositions useful for treatment of a subject are provided herein. Also provided are methods for administering probiotic or pre-biotic compositions.
    Type: Application
    Filed: June 16, 2014
    Publication date: January 8, 2015
    Inventors: David Mills, Daniel Garrido, Santiago Ruiz-Moyano, Carlito Lebrilla, J. Bruce German
  • BOVINE MILK OLIGOSACCHARIDES
    Publication number: 20130195803
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Application
    Filed: July 12, 2011
    Publication date: August 1, 2013
    Applicant: The Regents of the University of California
    Inventors: J. Bruce German, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
  • Prebiotic oligosaccharides
    Patent number: 8425930
    Abstract: The present invention provides galacto-oligosaccharide compositions that preferentially stimulate growth of specific Bifidobacterium species and subspecies.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: April 23, 2013
    Assignees: The Regents of the University of California, DSM Food Specialties USA Inc.
    Inventors: Mariana Barboza, J. Bruce German, Carlito Lebrilla, David Mills, Samara Freeman, William Robert King
  • Bifidobacterial gene sequences and their use
    Patent number: 8361756
    Abstract: This invention provides nucleic acids and proteins involved in oligosaccharide modification in the species Bifidobacteria. The invention provides methods for utilizing the proteins of the invention to generate human milk oligosaccharides or oligosaccharide mimics. The invention also provides compositions containing the human milk oligosaccharides or oligosaccharide mimics and methods for use.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: January 29, 2013
    Assignee: The Regents of the University of California
    Inventors: David A. Mills, Carlito B. Lebrilla, J. Bruce German, David Sela