Patents by Inventor J. Bruce Pitner
J. Bruce Pitner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220146514Abstract: Some embodiments provided herein relate to combined assays. In some embodiments, an assay for identifying influenza type A or influenza type B is combined with an assay for determining the sensitivity of an influenza neuraminidase to an antiviral drug.Type: ApplicationFiled: November 16, 2021Publication date: May 12, 2022Inventors: Robert Campbell, Kevin G. Dolan, Eric Fallows, Randal A. Hoke, Ross Jacobson, J. Bruce Pitner, Glenn P. Vonk, Rajashaker Kache, Upma Gulati, Herman D. Himel, IV, Rosemary B. Evans-Storms
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Patent number: 11209433Abstract: Some embodiments provided herein relate to combined assays. In some embodiments, an assay for identifying influenza type A or influenza type B is combined with an assay for determining the sensitivity of an influenza neuraminidase to an antiviral drug.Type: GrantFiled: April 15, 2019Date of Patent: December 28, 2021Assignee: Becton, Dickinson and CompanyInventors: Robert Campbell, Kevin G. Dolan, Eric Fallows, Randal A. Hoke, Ross Jacobson, J. Bruce Pitner, Glenn P. Vonk, Rajashaker Kache, Upma Gulati, Herman D. Himel, IV, Rosemary B. Evans-Storms
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Publication number: 20190339272Abstract: Some embodiments provided herein relate to combined assays. In some embodiments, an assay for identifying influenza type A or influenza type B is combined with an assay for determining the sensitivity of an influenza neuraminidase to an antiviral drug.Type: ApplicationFiled: April 15, 2019Publication date: November 7, 2019Inventors: Robert Campbell, Kevin G. Dolan, Eric Fallows, Randal A. Hoke, Ross Jacobson, J. Bruce Pitner, Glenn P. Vonk, Rajashaker Kache, Upma Gulati, Herman D. Himel, IV, Rosemary B. Evans-Storms
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Patent number: 10317404Abstract: Some embodiments provided herein relate to combined assays. In some embodiments, an assay for identifying influenza type A or influenza type B is combined with an assay for determining the sensitivity of an influenza neuraminidase to an antiviral drug.Type: GrantFiled: April 1, 2014Date of Patent: June 11, 2019Assignee: BECTON, DICKINSON AND COMPANYInventors: Robert Campbell, Kevin G. Dolan, Eric Fallows, Randal A. Hoke, Ross Jacobson, J. Bruce Pitner, Glenn P. Vonk, Rajashaker Kache, Upma Gulati, Herman Himel, Rosemary B. Evans-Storms
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Publication number: 20150018641Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: ApplicationFiled: July 1, 2013Publication date: January 15, 2015Applicant: Becton, Dickinson and CompanyInventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Patent number: 8389290Abstract: The current invention relates to sensing elements and devices comprising at least one amphipathic lipid-binding protein or fatty acid binding protein, wherein the binding proteins are associated with a luminescent reporter group. The binding proteins and luminescent reporter groups are encapsulated within a hydrogel matrix that comprises at least one co-monomer, wherein the co-monomer is present at a concentration that decreases or inhibits micelle formation of the amphipathic lipid. Binding of the amphipathic lipid or fatty acid to the appropriate binding protein can produce at least one detectable change in the property of the luminescent reporter group.Type: GrantFiled: December 1, 2008Date of Patent: March 5, 2013Assignee: Becton, Dickinson and CompanyInventors: W. Shannon Dillmore, J. Bruce Pitner
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Publication number: 20120100631Abstract: The current invention relates to sensing elements and devices comprising at least one amphipathic lipid-binding protein or fatty acid binding protein, wherein the binding proteins are associated with a luminescent reporter group. The binding proteins and luminescent reporter groups are encapsulated within a hydrogel matrix that comprises at least one co-monomer, wherein the co-monomer is present at a concentration that decreases or inhibits micelle formation of the amphipathic lipid. Binding of the amphipathic lipid or fatty acid to the appropriate binding protein can produce at least one detectable change in the property of the luminescent reporter group.Type: ApplicationFiled: December 1, 2008Publication date: April 26, 2012Inventors: W. Shannon Dillmore, J. Bruce Pitner
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Patent number: 8129525Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Nile Red nucleus dyes are disclosed having thiol-reactive groups. Nile Red nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm.Type: GrantFiled: June 22, 2009Date of Patent: March 6, 2012Assignee: Becton Dickinson and CompanyInventors: J. Bruce Pitner, Douglas B. Sherman, Arounaguiry Ambroise, Joseph Thomas
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Patent number: 8071794Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.Type: GrantFiled: June 22, 2009Date of Patent: December 6, 2011Assignee: Becton, Dickinson and CompanyInventors: J. Bruce Pitner, Douglas B. Sherman, Joseph Thomas
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Publication number: 20110184168Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.Type: ApplicationFiled: June 22, 2009Publication date: July 28, 2011Applicant: Becton, Dickinson and CompanyInventors: J. Bruce PITNER, Douglas B. SHERMAN, K. Joseph THOMAS
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Publication number: 20110184259Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: ApplicationFiled: August 23, 2010Publication date: July 28, 2011Inventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman, Steven Keith
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Patent number: 7851593Abstract: The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived therefrom, and their use as analyte biosensors both in vitro and in vivo.Type: GrantFiled: February 12, 2004Date of Patent: December 14, 2010Assignee: Becton, Dickinson and CompanyInventors: Helen Vivian Hsieh, J. Bruce Pitner, Terry J. Amiss, Colleen M. Nycz, Douglas B. Sherman, David J. Wright
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Patent number: 7792561Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.Type: GrantFiled: August 16, 2007Date of Patent: September 7, 2010Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. Denuzzio, Christopher C. Herdman, Ross Wayne Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Patent number: 7787923Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: GrantFiled: October 19, 2004Date of Patent: August 31, 2010Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amis, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman, Steven Keith
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Patent number: 7767821Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.Type: GrantFiled: June 22, 2009Date of Patent: August 3, 2010Assignee: Becton, Dickinson & CompanyInventors: J. Bruce Pitner, Douglas B. Sherman, Joseph Thomas
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Publication number: 20100167417Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.Type: ApplicationFiled: June 22, 2009Publication date: July 1, 2010Applicant: Becton, Dickinson and CompanyInventors: J. Bruce Pitner, Douglas B. Sherman, K. Joseph Thomas
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Publication number: 20100003763Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.Type: ApplicationFiled: June 22, 2009Publication date: January 7, 2010Applicant: Becton, Dickinson and CompanyInventors: J. Bruce Pitner, Douglas B. Sherman, Arounaguiry Ambroise, K. Joseph Thomas
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Patent number: 7629172Abstract: The invention is directed to entrapped mutated binding proteins, mutated binding proteins containing reporter groups, compositions of mutated binding proteins containing reporter groups in analyte permeable matrixes, and their use as analyte biosensors both in vitro and in vivo.Type: GrantFiled: September 27, 2004Date of Patent: December 8, 2009Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcon, Christopher J. Knors, J. Bruce Pitner
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Patent number: 7563891Abstract: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.Type: GrantFiled: May 18, 2005Date of Patent: July 21, 2009Assignee: Becton, Dickinson & CompanyInventors: J. Bruce Pitner, Douglas B. Sherman, Arounaguiry Ambroise, Joseph Thomas
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Patent number: 7496392Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is described. An optical conduit, preferably an optical fiber, has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and may include at least one binding protein adapted to bind with at least one target analyte. The sensing element further may also include at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.Type: GrantFiled: November 26, 2003Date of Patent: February 24, 2009Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcón, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross Wayne Jacobson, J. Bruce Pitner, Douglas B. Sherman