Abstract: The present invention provides an antibody or antigen-binding fragment thereof that binds ?v?3 integrin, as well as methods of use in the treatment of diseases and disorders.

Abstract: Methods and systems of detection of presence in and delivery to location are provided. A method detects a presence of a mobile device within a perimeter of a geographic region. The method searches a database to determine whether the first mobile device is associated with any existing account. Responsive to determining that the mobile device is associated with a first account, the method searches the database to determine whether there is any pending task associated with the first account. Responsive to determining that there is a pending task associated with the first account, the method transmits a first message indicating the detection of presence of the mobile device associated with the first account. The method determines that the mobile device is at least approximately at a first location of a plurality of predefined locations within the perimeter. The method transmits information associated with the first location to the computing device.

Abstract: The present invention provides an antibody or antigen-binding fragment thereof that binds ?v?3 integrin, as well as methods of use in the treatment of diseases and disorders.

Abstract: Provided herein is an isolated antibody or antigen-binding fragment that specifically binds tau, the antibody or fragment comprising a heavy chain variable (VH) region and a light chain variable (VL) region having amino acid sequences set forth herein. Also provided are methods of preventing or treating a tauopathy in a subject, comprising administering to a human in need of therapy for a tauopathy with one or more antibodies or fragments as described herein, wherein the antibodies or antigen-binding fragment are administered under conditions and in an amount effective to prevent or treat the tauopathy.

Abstract: A system and computer program product of handling multiple backup processes have been provided. The system comprises receiving one or more instructions initiating a plurality of backup processes from a single source storage volume to a plurality of target storage volumes, adding each target storage volume to a cascade of target storage volumes from the source storage volume, the target storage volumes added to the cascade in an order inversely proportional to the copy rate of the respective backup process such that a first target storage volume added to the cascade of target storage volumes has a slowest copy rate, a next added target storage volume to the cascade of target storage volumes has a faster copy rate than an immediately prior added target storage volume, and a most recent target storage volume added to the cascade of target storage volumes has a fastest copy rate.

Abstract: A method comprises creating a cascade of target storage volumes from a plurality of target storage volumes by inserting each most recent target storage volumes between a last added target storage volume and a source storage volume, the most recent target storage volumes each having a copy rate faster than the last added target storage volume, such that each added target storage volume has a faster copy rate than an immediately prior added target storage volume, and a most recent target storage volume added to the cascade of target storage volumes has a fastest copy rate; and receiving one or more instructions initiating a plurality of backup processes from the source storage volume to a plurality of target storage volumes.

Abstract: A method of handling multiple served backup processes comprising creating a cascade of target storage volumes from a plurality of target storage volumes by inserting each most recent target storage volumes between a last added target storage volume and a source storage volume, the most recent target storage volumes each having a copy rate faster than the last added target storage volume, such that each added target storage volume has a faster copy rate than an immediately prior added target storage volume, and a most recent target storage volume added to the cascade of target storage volumes has a fastest copy rate; and receiving one or more instructions initiating a plurality of served backup processes from the source storage volume to a plurality of target storage volumes.

Abstract: The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

Abstract: A method of updating existing screen printing or other manufacturing processing in order to generate sheets and other bedding with marking indicators for proper alignment of the covering on a mattress, and the covering as produced. For a top sheet it would be marked along the top edge of the sheet as well as the body of the sheet which contacts the corners of the mattress at the foot of the bed, and for a fitted bottom sheet the markings would occur at each corner of the sheet which is associated with a corner of the mattress. Optional side indicators located between the corner indicators may also be included. The purpose is to provide a quick and easy identifier for locating the corners of the mattress with the sheet so that the sheet is quickly and easily placed symmetrically upon the mattress the first time.

Abstract: An expandable clothes rack, including a first vertical longitudinal wood member, having a plurality of spaced apertures; a plurality of parallel wood dowels, each dowel fixedly secured within one of the spaced apertures within the first vertical longitudinal wood member, such that the dowel extends outwardly on either side of the first vertical longitudinal wood member; and, a second vertical longitudinal wood member including a plurality of parallel spaced metal tubes fixedly secured to and extending outwardly from the second vertical longitudinal wood member, and operatively arranged to telescopingly engage the plurality of parallel wood dowels to form a ladder-like structure.

Abstract: A method of handling multiple served backup processes comprising creating a cascade of target storage volumes from a plurality of target storage volumes by inserting each most recent target storage volumes between a last added target storage volume and a source storage volume, the most recent target storage volumes each having a copy rate faster than the last added target storage volume, such that each added target storage volume has a faster copy rate than an immediately prior added target storage volume, and a most recent target storage volume added to the cascade of target storage volumes has a fastest copy rate; and receiving one or more instructions initiating a plurality of served backup processes from the source storage volume to a plurality of target storage volumes.

Abstract: The present invention provides an antibody or antigen-binding fragment thereof that binds ?v?3 integrin, as well as methods of use in the treatment of diseases and disorders.

Abstract: A method comprises creating a cascade of target storage volumes from a plurality of target storage volumes by inserting each most recent target storage volumes between a last added target storage volume and a source storage volume, the most recent target storage volumes each having a copy rate faster than the last added target storage volume, such that each added target storage volume has a faster copy rate than an immediately prior added target storage volume, and a most recent target storage volume added to the cascade of target storage volumes has a fastest copy rate; and receiving one or more instructions initiating a plurality of backup processes from the source storage volume to a plurality of target storage volumes.

Abstract: The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

Abstract: The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.

Abstract: Techniques for providing friction-free transactions using geolocation and user identifiers are described herein. These techniques may ascertain a user's location based on a location of a mobile device. A transaction between the user and a merchant may be completed with zero or minimal input from the user based on the geolocation of the mobile device and the user identifiers. In some implementations, a transaction initiated earlier is completed when the mobile device arrives at the merchant. Additionally, a parent-child or similar relationship may be established between multiple devices. Security on the mobile device based may be provided by biometric identification and calculation of variance from regular movement patterns. Advertisements may be sent to the mobile device based on bids from merchants near to the mobile device. Promotions may be sent to the mobile device when more than a threshold number of mobile devices are located at the same merchant.

Abstract: The present invention provides an antibody or antigen-binding fragment thereof that binds ?V?3 integrin, as well as methods of use in the treatment of diseases and disorders.

Abstract: A method comprises receiving one or more instructions initiating a plurality of backup processes from a single source storage volume to a plurality of target storage volumes, adding each target storage volume to a cascade of target storage volumes from the source storage volume, the target storage volumes added to the cascade in an order inversely proportional to the copy rate of the respective backup process, and starting each backup process in turn, the backup processes started in an order from the most recent target storage volume added to cascade to the first target storage volume added to cascade.

Abstract: A system and computer program product of handling multiple backup processes have been provided. The system comprises receiving one or more instructions initiating a plurality of backup processes from a single source storage volume to a plurality of target storage volumes, adding each target storage volume to a cascade of target storage volumes from the source storage volume, the target storage volumes added to the cascade in an order inversely proportional to the copy rate of the respective backup process such that a first target storage volume added to the cascade of target storage volumes has a slowest copy rate, a next added target storage volume to the cascade of target storage volumes has a faster copy rate than an immediately prior added target storage volume, and a most recent target storage volume added to the cascade of target storage volumes has a fastest copy rate.