Abstract: Ophthalmic lens molds include first and second mold members sized and adapted to be assembled, for example interference fitted, together to define a lens-shaped cavity therebetween. At least one of the mold members includes a polar polymeric material and has a flexural modulus less than 3800 MPa.

Abstract: Contact lenses ready for use in an eye are provided including a contact lens body containing a hydrophilic polymeric component and a water soluble polymer component. Such contact lenses, which preferably are wet cast molded, are particularly useful as disposable or single use lenses. New contact lens packaging systems and production methods are also provided.

Abstract: Methods of correcting vision are described. The methods include inserting a lens into a corneal epithelial pocket or a pocket created between a corneal epithelium of an eye of a patient and Bowman's membrane of the eye. A lens is inserted into the pocket to correct vision. Certain methods include one or more steps of cooling the corneal epithelium, and applying an aqueous liquid to the eye. The lenses that are inserted into the pocket can include collagen, including recombinant collagen, synthetic polymeric materials, and combinations thereof.

Abstract: Contact lenses ready for use in an eye are provided including a contact lens body containing a hydrophilic polymeric component and a water soluble polymer component. Such contact lenses, which preferably are wet cast molded, are particularly useful as disposable or single use lenses. New contact lens packaging systems and production methods are also provided.

Abstract: Methods for improving vision in a person diagnosed with presbyopia include placing a corneal onlay lens having a lens body diameter less than 5 mm in contact with an eye of the person. The corneal onlay lens has at least one refractive region having a refractive power to correct vision effects caused by the presbyopia. If the person is a presbyopic emmetrope, the method may include a step of placing only one corneal onlay lens in the person to treat presbyopia or improve the vision of the person. Additional corneal onlay lenses and methods of making such corneal onlay lenses are also described.

Abstract: Devices and methods for improving vision are described. The vision of a person can be corrected using a corneal onlay or a lens positioned between an epithelial cell layer and Bowman's membrane of the person's eye. Wavefront aberrations are measured for the person's eye or eyes, and the aberrations are used to shape the corneal onlay to provide a desired vision correction power, or to shape the person's cornea.

Abstract: Contact lenses ready for use in an eye are provided including a contact lens body containing a hydrophilic polymeric component and a water soluble polymer component. Such contact lenses, which preferably are wet cast molded, are particularly useful as disposable or single use lenses. New contact lens packaging systems and production methods are also provided.

Abstract: Biocompatible polymers and adhesives have a cyanoacrylic core and other substituents such as therapeutic agents, targeting moieties, imaging agents, amino acid residues or other organic moieties. Exemplary uses of inventive compositions include use as sealants and adhesives for medical uses, and as polymeric formulations for biocompatible implants and matrices and drug delivery.

Abstract: Corneal onlays and method of making and using corneal onlays are described. The present corneal onlays may have clinically acceptable lens bodies for use in human eyes. The present corneal onlays may have one or more physical features that contribute to the success of the present onlays in human eyes.

Abstract: Contact lenses for use in eyes are provided and include a lens body and a plurality of microchannels defined in a posterior face of the lens body. The microchannels are structured to promote effective tear fluid exchange between an exposed surface of the eye and a surface of the eye covered by the lens body. Each of the microchannels preferably includes a substantially junctionless, convex surface along a major portion of a length of the microchannel.

Abstract: Contact lenses for use in eyes are provided and include a lens body and a plurality of microchannels defined in a posterior face of the lens body. The microchannels are structured to promote effective tear fluid exchange between an exposed surface of the eye and a surface of the eye covered by the lens body. Each of the microchannels preferably includes a substantially junctionless, convex surface along a major portion of a length of the microchannel.

Abstract: Devices, methods, and compositions for improving vision or treating diseases, disorders or injury of the eye are described. Ophthalmic devices, such as corneal onlays, corneal inlays, and full-thickness corneal implants, are made of a material that is effective in facilitating nerve growth through or over the device. The material may include an amount of collagen greater than 1% (w/w), such as between about 10% (w/w) and about 30% (w/w). The material may include collagen polymers and/or a second biopolymer or water-soluble synthetic polymer cross-linked using EDC/NHS chemistry. The material may additionally comprise a synthetic polymer. The devices are placed into an eye to correct or improve the vision of an individual or to treat a disease, disorder or injury of an eye of an individual.

Abstract: Contact lenses for use in eyes are provided and include a lens body and a plurality of microchannels defined in a posterior face of the lens body. The microchannels are structured to promote effective tear fluid exchange between an exposed surface of the eye and a surface of the eye covered by the lens body. Each of the microchannels preferably includes a substantially junctionless, convex surface along a major portion of a length of the microchannel.

Abstract: Contact lenses ready for use in an eye are provided including a contact lens body containing a hydrophilic polymeric component and a water soluble polymer component. Such contact lenses, which preferably are wet cast molded, are particularly useful as disposable or single use lenses. New contact lens packaging systems and production methods are also provided.

Abstract: Contact lenses for use in eyes are provided and include a lens body and a plurality of radially extending microchannels defined in the posterior face of the lens body. In one embodiment, the microchannels are sized and adapted to promote effective tear fluid exchange between an exposed surface of the eye and a surface of the eye covered by the lens body without substantially interfering with the optical zone function of the lens body.

Abstract: Contact lenses for use in eyes are provided and include a lens body and a plurality of microchannels defined in a posterior face of the lens body. The microchannels are structured to promote effective tear fluid exchange between an exposed surface of the eye and a surface of the eye covered by the lens body. Each of the microchannels preferably includes a substantially junctionless, convex surface along a major portion of a length of the microchannel.

Abstract: A tinted or colored contact lens has a pupil section, an iris section having an area and circumferentially surrounding the pupil section, and a colorant component extending across a major portion of the area of the iris section. The colorant component provides a color to the iris section and at least one additional benefit to the contact lens. For example, the colorant component may enhance the natural appearance of the iris section when the contact lens is in an eye. Alternatively or in addition, the colorant component may enhance the perception of depth in the iris section by an ordinary viewer. Still further, the colorant component may provide a darkened-image within an outer portion of the iris section.

Abstract: Contact lenses for use in eyes are provided and include a lens body and a plurality of radially extending microchannels defined in the posterior face of the lens body. In one embodiment, the microchannels are sized and adapted to promote effective tear fluid exchange between an exposed surface of the eye and a surface of the eye covered by the lens body without substantially interfering with the optical zone function of the lens body.