Abstract: Systems and methods are described for removing an embolus in a cerebral vessel of a patient. The assembled system of devices includes a catheter having a catheter lumen and a distal end and a catheter advancement element extending through the catheter lumen. A tapered distal end region of the catheter advancement element extends distal to the distal end of the catheter. The assembled system of devices is advanced together towards an occlusion site in a cerebral vessel of a patient visible on angiogram. The occlusion site includes an angiographic limit of contrast and an embolus downstream of the angiographic limit of contrast. The catheter advancement element is advanced to a location past the angiographic limit of contrast without crossing the embolus. The catheter is advanced to position the distal end of the catheter at a treatment site located past the angiographic limit of contrast and aspiration applied.

Abstract: The dental wedge has an elongated body extending from an outer end to an opposite inner end. The body includes a longitudinal intermediate wall, a longitudinal first side wall connected to the intermediate wall, and a longitudinal second side wall connected to the intermediate wall. The first side wall and the second side wall each flare away from the intermediate wall such that a first distal end of the first side wall and a second distal end of the second side wall are spaced apart creating an inverted generally V-shaped transverse section for the body. The body has a top surface and a bottom surface formed by the intermediate wall, the first side wall and the second side wall. The intermediate wall includes a region of increased flexibility compared to each of the first side wall and the second side wall.

Abstract: A dental separator device includes an elastic body having a first end and a second end. A first surface engager is connected to the first end of the body. The first surface engager includes a first distal section and a first mesial section and a notch between the first distal section and the first mesial section. The first distal section and the first mesial section each include a pair of spaced apart hands. A second surface engager is connected to the second end of the body. The second surface engager includes a second distal section and a second mesial section, and a notch between the second distal section and the second mesial section. The second distal section and the second mesial section each include a pair of spaced apart hands. The hands are for engaging teeth and/or for creating adaptation pressure on a dental matrix stabilizer and/or dental matrix.

Abstract: An automation apparatus for dispensing groups of individually packaged products, the apparatus including a storage arrangement adapted to store a plurality of products each contained in an individual package. The storage arrangement includes a first module and a second module, where the first module is adapted to store products having a first frequency demand threshold and the second module is adapted to store products having a second frequency demand threshold that is lower than the first frequency demand threshold. The apparatus further includes a plurality of fixed first discharge assemblies adapted to move selected ones of the individual packages from the first module of the storage arrangement and a second discharge assembly comprising a moveable pick device adapted to move selected ones of the individual packages out of the second module of the storage arrangement.

Abstract: An integrated system and method measures building characteristics and user behavior to provide real-time and forecasted utility usages and costs. The system gathers current and historical heating and cooling load data, compares the data with current and historical weather data and a building system set point, and calculates the heating or cooling load needed for the building based on the user's call for heat or cooling and the ambient environmental conditions. The system additionally analyzes individual device usage using usage signatures and user inputted tracking to create a comprehensive real-time and forecast of utility usages with the estimated costs. Through history of selections with usage changes corresponding to user input of individual devices, the system will be able to learn various devices' usage. The system then creates a comprehensive, real-time forecast of utility costs including the foregoing characteristics.

Abstract: Newly identified fungal sweet-taste modifying proteins (designated Honey Truffle Sweetener (HTS)), and polynucleotides encoding the proteins are described. Specifically, Myd proteins with sweet taste modulation activity, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed are sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.

Abstract: Embodiments of collapsible wheels and methods of making collapsible wheels are generally described herein. Other embodiments may be described and claimed.

Abstract: Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract: Shaped charge devices, systems, and related methods of use. A housing sheet is configurable to form at least part of a shaped charge enclosure enclosing a shaped charge and biasing an explosion in a desired direction. The housing sheet can include one or more incisions in at least one surface thereof. The housing sheet can have at least one connection mechanism integrally formed therein, and the housing sheet can be configurable to form a plurality of sizes of shaped charge housing portions. The housing sheet can also provide for forming a plurality of dimensions of the shaped charge enclosure.

Abstract: A piston assembly that includes a pair of piston members that are formed of compacted powdered metal. The piston members have sets of locking features that include alternating projections and recesses that are spaced circumferentially about and intersect a rod aperture that extends through the piston member. Each projection is formed along a projection axis, which extends radially from a center axis along which the rod aperture is formed, and has a pair of opposite side walls and an end wall that connects the side walls to one another on a side of the projection that is opposite the rod aperture. The recesses on each piston member are configured to matingly and frictionally receive the projections on the other piston member.

Abstract: The present invention relates to methods for the restoration of a decayed portion of a tooth or re-restoration of a previously filled tooth, and to dental capsules and dental composite resin dispensers that may be used in the methods for the restoration of a decayed portion of a tooth.

Abstract: A system includes a printed circuit board (PCB). The PCB includes a radio frequency (RF) circuit that includes a plurality of circuit modules and signal trace lines. Each circuit module is electrically connected to at least one other circuit module by a signal trace line. The system includes a via fence comprising fence walls having at least two materials laminated using a printed wire board (PWB) process. The fence walls include a plurality of vias. The fence walls form a plurality of free-form RF isolation chambers, each chamber includes chamber walls that surround each circuit module outside of the PCB. The embodiments also include a method of manufacturing and/or isolating the system or components of the system.

Abstract: Thermal regulating units are provided. Each thermal regulating unit includes a first thermally conductive layer in contact with the skin of the body. The first thermally conductive layer is embedded with electrical wiring and a first passive thermometer sensor. A plurality of spaced apart thermoelectric coolers are provided on the first thermal conductivity layer. A second thermally conductive layer opposite the first layer is exposed to ambient air or fluid. The second thermally conductive layer includes embedded electrical wiring and a second passive thermometer sensor. A thermal insulating layer is provided between the first and second thermally conductive layers. The thermal insulating layer creates a thermal barrier therebetween and adheres the first and second thermally conductive layer together. The thermal regulating unit operates responsive to a controller to regulate the temperature of a user based on the feedback of the one or more thermal regulating units.

Abstract: A medical device for left atrial appendage closure includes a support frame with a proximal collar and a distal collar, where the support frame is actuatable from a first constrained configuration to a second radially expanded configuration. A membrane is disposed on at least a portion of the support frame, and an engagement element is coupled to the distal end region of the support frame. The engagement element extends distally from the support frame and is configured to engage an inner surface of the left atrial appendage and prevent the support frame from sliding along the inner surface of the left atrial appendage during implantation.

Abstract: Described are multifocal contact lenses that contain high energy visible (HEV) light absorbing compounds and their use for improving one or more vision attributes.

Abstract: A drug delivery system for delivering a drug product is provided that includes a drug product container containing a drug product, a fluid path adapted to receive the drug product from the drug product container, and a drug delivery device positioned along and/or adjacent to the fluid path. The drug delivery device may include a housing, a fluid displacement assembly at least partially supported by and/or surrounded by the housing, and a drive component at least partially supported by and/or surrounded by the housing. The drive component may drive the medicament through the fluid displacement assembly. Further, the drug delivery device includes a controller workingly coupled with the drive component for controlling the drug delivery device. The controller may operate in a normal operation mode and a reserve mode.

Abstract: A drug delivery system includes a packaging housing a first component including at least one of a drug product, a diluent, a saline solution, or an IV stabilizing solution (“IVSS”) and a second component comprising at least one of the drug product, the diluent, the saline solution, and the IVSS, the first component being different than the second component. The first component is disposed in a first container in a storage state and the first container is positioned in a first compartment of the packaging housing. The second component is disposed in a second container in a storage state and the second container is positioned in a second compartment of the packaging housing. At least one of the first compartment and the second compartment may include an individual seal and wherein each of the individual seals and the first and second compartments are sterilized.

Abstract: The disclosure relates to insecticidal toxin resistance management and screening of novel insecticidal toxins. One embodiment relates to the isolation, characterization, compositions, and methods of use relating to polynucleotides encoding novel insecticidal toxin receptors and the polypeptides encoded thereby. The polynucleotides and polypeptides are useful in identifying or designing novel insecticidal toxin receptor ligands including novel insecticidal toxins.

Abstract: A device for connecting tubes for a drug delivery system includes a connecting portion having a first tube channel, a second tube channel, a connecting heating element, and a carriage assembly. The first tube channel is adapted to receive a first tube, and the second tube channel is adapted to receive a second tube. The connecting heating element is positioned adjacent to and/or intersecting the first and second tube channels and is adapted to selectively heat at least a portion of the first and second tube. The carriage assembly moves the heated first and second tubes into end-to-end contact with each other to couple the first and second tubes together.

Abstract: An approach for determining material compatibility for components of a drug delivery system is provided that includes using surface zeta-potential analytical method to evaluate surface interactions between a desired molecule and at least one material present within a given IV-bag system.