Patents by Inventor J. David Lambeth

J. David Lambeth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mitogenic oxygenase regulators
    Patent number: 7524936
    Abstract: The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: April 28, 2009
    Assignee: Emory University
    Inventors: J. David Lambeth, Guangjie Chang
  • Mitogenic oxygenases
    Patent number: 7247709
    Abstract: The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: July 24, 2007
    Assignee: Emory University
    Inventors: J. David Lambeth, Kathy K. Griendling, Bernard P. Lassegue, Rebecca S. Arnold, Guangjie Cheng
  • Regulatory protein for Nox enzymes
    Patent number: 7244590
    Abstract: The present invention relates to nucleotides encoding for the production of novel regulatory proteins for Nox enzymes involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these nucleotides, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these nucleotides and proteins, and methods to determine the activity of drugs to affect the biological activity of the regulatory proteins of the present invention.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: July 17, 2007
    Assignee: Emory University
    Inventors: J. David Lambeth, Guangjie Cheng
  • Dual oxidases as mitogenic and endocrine regulators
    Patent number: 7226769
    Abstract: The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates and in peroxidative reactions that affect biological functions including cell division, thyroid hormone biosynthesis and tissue fibrosis. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: June 5, 2007
    Assignee: Emory University
    Inventors: J. David Lambeth, Bernard P. Lassegue, Kathy K. Griendling, Rebecca S. Arnold, Guangjie Cheng, Lisa Sharling, Guy Benian, William A. Edens
  • Mitogenic oxygenase regulators
    Patent number: 7202053
    Abstract: The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: April 10, 2007
    Assignee: Emory University
    Inventors: J. David Lambeth, Guangjie Cheng
  • Mitogenic oxygenase regulators
    Patent number: 7202052
    Abstract: The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: April 10, 2007
    Assignee: Emory University
    Inventors: J. David Lambeth, Guangjie Cheng
  • Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates
    Patent number: 7119249
    Abstract: The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The present invention additionally comprises cells and cell lines containing transgenes encoding for members of the NOX and Duox family of proteins. The present invention further comprises methods and compositions for evaluating regulators of abnormal cell growth and in the development of compounds that effect ROI expression.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: October 10, 2006
    Assignee: Emory University
    Inventors: J. David Lambeth, Guangjie Cheng, James McCoy
  • Antibodies to mitogenic oxygenases
    Patent number: 7048923
    Abstract: The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: May 23, 2006
    Assignee: Emory University
    Inventors: J. David Lambeth, Kathy K. Griendling, Bernard P. Lassegue, Rebecca S. Arnold, Guangjie Cheng
  • Mitogenic oxygenases
    Patent number: 7045351
    Abstract: The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: May 16, 2006
    Assignee: Emory University
    Inventors: J. David Lambeth, Kathy K. Griendling, Bernard P. Lassegue, Rebecca S. Arnold, Guangie Cheng
  • Regulatory protein for Nox enzymes
    Patent number: 7029673
    Abstract: The present invention relates to nucleotides encoding for the production of novel regulatory proteins for Nox enzymes involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these nucleotides, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these nucleotides and proteins, and methods to determine the activity of drugs to affect the biological activity of the regulatory proteins of the present invention.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: April 18, 2006
    Assignee: Emory University
    Inventors: J. David Lambeth, Guangjie Cheng
  • Mitogenic oxygenase regulators
    Patent number: 6846672
    Abstract: The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: January 25, 2005
    Assignee: Emory University
    Inventors: J. David Lambeth, Guangjie Cheng
  • Mitogenic oxygenase regulators
    Publication number: 20040253681
    Abstract: The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Application
    Filed: May 20, 2004
    Publication date: December 16, 2004
    Inventors: J. David Lambeth, Guangjie Cheng
  • Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates
    Publication number: 20040093628
    Abstract: The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The present invention additionally comprises cells and cell lines containing transgenes encoding for members of the NOX and Duox family of proteins. The present invention further comprises methods and compositions for evaluating regulators of abnormal cell growth and in the development of compounds that effect ROI expression.
    Type: Application
    Filed: July 14, 2003
    Publication date: May 13, 2004
    Inventors: J. David Lambeth, Guangjie Cheng, James McCoy
  • Regulatory protein for nox enzymes
    Publication number: 20040091466
    Abstract: The present invention relates to nucleotides encoding for the production of novel regulatory proteins for Nox enzymes involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these nucleotides, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these nucleotides and proteins, and methods to determine the activity of drugs to affect the biological activity of the regulatory proteins of the present invention.
    Type: Application
    Filed: July 16, 2003
    Publication date: May 13, 2004
    Inventors: J. David Lambeth, Guangjie Cheng
  • Human mitogenic oxidase
    Patent number: 6620603
    Abstract: The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: September 16, 2003
    Assignee: Emory University
    Inventors: J. David Lambeth, Kathy K. Griendling, Bernard P. Lassegue, Rebecca S. Arnold, Guangjie Cheng
  • Antibodies to mitogenic oxygenases
    Publication number: 20030166198
    Abstract: The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Application
    Filed: December 13, 2002
    Publication date: September 4, 2003
    Inventors: J. David Lambeth, Kathy K. Griendling, Bernard P. Lassegue, Rebecca S. Arnold, Guangjie Cheng
  • Mitogenic oxygenases
    Publication number: 20030157678
    Abstract: The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Application
    Filed: December 13, 2002
    Publication date: August 21, 2003
    Inventors: Kathy K. Griendling, Bernard P. Lassegue, J. David Lambeth, Rebecca S. Arnold, Guangjie Cheng
  • Mitogenic oxygenase regulators
    Publication number: 20020176852
    Abstract: The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Application
    Filed: November 15, 2001
    Publication date: November 28, 2002
    Inventors: J. David Lambeth, Guangjie Cheng