Patents by Inventor J. David Port

J. David Port has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying pharmacologicals for the treatment of heart failure
    Patent number: 6436636
    Abstract: Methods are disclosed for treating heart failure. Methods are disclosed for screening pharmacologicals that inhibit the down-regulatory activity of AUF1 or AUF1-related polypeptide for &bgr;-adrenergic activity. Methods are disclosed for treating a patient with a high level of the AUF1 or AUF1-related gene.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: August 20, 2002
    Assignees: Wake Forest University, University Technology Corporation
    Inventors: J. David Port, Gary Brewer
  • Transgenic model and treatment for heart disease
    Patent number: 6218597
    Abstract: The invention provides a transgenic mouse that is a model for heart muscle disease and heart failure. Also provided are methods of using the transgenic mouse model to study heart muscle disease and heart failure and conditions and treatments related thereto.
    Type: Grant
    Filed: April 1, 1998
    Date of Patent: April 17, 2001
    Assignee: University Technology Corporation
    Inventors: J. David Port, Michael R. Bristow
  • Method for identifying adrenergic receptor antagonists having good tolerability
    Patent number: 6203776
    Abstract: Disclosed are methods to identify adrenergic receptor antagonists having good tolerability. These methods include measuring the inverse agonist activity and/or the intrinsic sympathomimetic activity of an adrenergic receptor antagonist. Also disclosed are a method to treat heart failure and compounds useful therefor.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: March 20, 2001
    Assignee: University Technology Corporation
    Inventors: Michael R. Bristow, J. David Port
  • Detecting and treating heart failure
    Patent number: 5733728
    Abstract: Methods are disclosed for detecting and treating heart failure which are based on the down-regulatory activity of the cytoplasmic RNA-binding polypeptide, AUF1 (A+U-rich element RNA-binding/degradation Factor) toward .beta.-adrenergic receptors. Methods are disclosed for detecting pharmacologicals that inhibit the down-regulatory activity of AUF1 polypeptide for .beta.-adrenergic activity. Methods are disclosed for treating a patient with a high level of the AUF1 gene.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: March 31, 1998
    Assignees: Regents of the University of Colorado, Wake Forest University
    Inventors: J. David Port, Gary Brewer