Abstract: Various embodiments of the present invention are directed to a mapping management computer system. According to various embodiments, the mapping management computer system may be configured for updating geographical maps by assessing map data and operational data including vehicle telematics data to identify portions of a vehicle path that do not correspond to known travel paths. In various embodiments, the system is configured to define these identified portions as new known travel paths corresponding to a public road, private road, parking lot lane, or the like, and update the map data to reflect the new known travel paths.

Abstract: COVID-19 results from the infection of the SARS-CoV-2 virus and has spread quickly to literally infected the world. Although coronavirus spike proteins can recognize a broad range of host cell-surface proteins, inhibiting spike protein binding to a survival factor called GRP78 results in a significant reduction in SARS-CoV-2 attachment, entry and replication in lung and kidney cells. This inhibition is accomplished with a novel type of inhibitor that potently blocks the binding of SARS-CoV-2 spike protein and whole virus to surface-bound GRP78. These novel GRP78 inhibitors also down regulate cytokines (IL10, IL6), immune co-inhibitory checkpoint proteins (PD-L1, B7H3, B7H4), and up regulate immune co-stimulatory proteins (MHC-II, CD-86) resulting in the reduction of the immune suppressive nature of infected lung alveolar epithelial cells in vitro and in vivo. Finally, these novel GRP78 inhibitors inhibit the hyperfibrinolysis of infected lung cells by reducing the activation of plasmin on cell surfaces.

Abstract: Provided is a last round bolt hold-open mechanism for a firearm with a removable ammunition magazine and a longitudinally reciprocating bolt that automatically releases the bolt when a loaded ammunition magazine is inserted. The mechanism includes a frame mountable to a firearm receiver and having a pair of mounting flanges. A catch member is pivotally mounted on a pivot axle oriented transverse to the longitudinal reciprocation of the bolt and carried by the mounting flanges. The catch member has a rearward portion that moves between bolt blocking and bolt release positions and is spring biased toward the bolt blocking position. A forwardly extending finger is configured to be lifted by the presence of at least one ammunition cartridge in the magazine and, when lifted, causes the catch member to pivot to the bolt release position.

Abstract: This disclosure relates generally to the use of automated platforms in the preparation of biomarker-stained cellular samples for microscopic analysis and use of such stained cells in the diagnosis of certain conditions. Disclosed herein is a method of affinity staining a Romanowsky-type stained sample on automated advanced staining systems, wherein the automated advanced stainer destains the sample prior to contact with a biomarker-specific reagent. Also disclosed herein are methods of processing body fluid samples for morphological and biomarker analysis by depositing cells of the sample in a thin layer onto one or more solid supports, staining at least one such solid support with a Romanowsky-type stain and staining at least one such solid support for one or more biomarkers useful for categorizing one or more cells of the sample.

Abstract: Glucose-regulated protein (GRP78) antagonists that block, interfere, and/or inhibit binding of receptor tyrosine kinase orphan receptors (RORs) are described for use as immunotherapy anticancer. These GRP78 antagonists inhibit surface bound GRP78 binding and receptor signaling and are believed to mimic the behavior of anti-angiogenic kringles found in mammalian plasminogen and in receptor tyrosine kinase orphan receptors. These GRP78 antagonist may be free peptide fragments, or peptide fragments covalently fused to blood borne proteins such as albumin or immunoglobins, or modified peptide fragments that a designed to bind to blood or tissue peptides when introduced in vivo into the blood stream of a patient.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for segmenting operational data and identifying events of interested in the segmented operational data. With the events of interest identified from the segmented operational data, a total time between the events of interest can be determined, evaluated, and provided.

Abstract: A multi-column box magazine for rimmed ammunition cartridges of varied lengths has an elongated housing with a neck portion where cartridges are arranged in a single column and a mouth at an upper feed end through which cartridges are inserted and extracted. In a multi-column portion, cartridges are arranged in laterally alternating columns, and in a transition portion the alternating columns are transitioned into the single column as the cartridges are moved toward the mouth within the housing. A follower is biased by a spring toward the mouth. The multi-column portion has a forward interior surface limiting forward movement position of cartridges, which varies depending on individual cartridge length, and the neck portion having a forwardly sloped rearward wall which confronts the cartridge rim and shifts the cartridge forward, as needed, as cartridges are moved upwardly within the housing to the mouth.

Abstract: Various embodiments of the present invention are directed to a mapping management computer system. According to various embodiments, the mapping management computer system may be configured for updating geographical maps by assessing map data and operational data including vehicle telematics data to identify portions of a vehicle path that do not correspond to known travel paths. In various embodiments, the system is configured to define these identified portions as new known travel paths corresponding to a public road, private road, parking lot lane, or the like, and update the map data to reflect the new known travel paths.

Abstract: A multi-column box magazine for rimmed ammunition cartridges of varied lengths has an elongated housing with a neck portion where cartridges are arranged in a single column and a mouth at an upper feed end through which cartridges are inserted and extracted. In a multi-column portion, cartridges are arranged in laterally alternating columns, and in a transition portion the alternating columns are transitioned into the single column as the cartridges are moved toward the mouth within the housing. A follower is biased by a spring toward the mouth. The multi-column portion has a forward interior surface limiting forward movement position of cartridges, which varies depending on individual cartridge length, and the neck portion having a forwardly sloped rearward wall which confronts the cartridge rim and shifts the cartridge forward, as needed, as cartridges are moved upwardly within the housing to the mouth.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for segmenting operational data and identifying events of interested in the segmented operational data. With the events of interest identified from the segmented operational data, a total time between the events of interest can be determined, evaluated, and provided.

Abstract: According to various embodiments, a fleet management system is provided for capturing, storing, and analyzing telematics data to improve fleet management operations. The fleet management system may be used, for example, by a shipping entity (e.g., a common carrier) to capture telematics data from a plurality of vehicle sensors located on various delivery vehicles and to analyze the captured telematics data. In particular, various embodiments of the fleet management system are configured to analyze engine idle data in relation to other telematics data in order to identify inefficiencies, safety hazards, and theft hazards in a driver's delivery process. The fleet management system may also be configured to assess various aspects of vehicle performance, such as vehicle travel delays and vehicle speeds.

Abstract: A feedthrough device includes a body having longitudinally spaced first and second end faces and an inner surface defining an opening extending longitudinally through the body, a conductor extending within the opening of the body, and an insulator extending within the opening of the body transversely intermediate the conductor and the inner surface of the body to insulate the conductor from the body, where the conductor includes an interior portion surrounded by the insulator and an exterior portion extending beyond the insulator, the exterior portion having a diameter that is greater than a diameter of the interior portion.

Abstract: Various embodiments of the present invention are directed to a fleet management system configured for capturing and evaluating vehicle telematics data, such as data captured from one or more vehicle telematics devices indicative of one or more vehicle dynamics, and service data, such as data captured from one or more portable data acquisition devices indicative of one or lore service dynamics. In certain embodiments, the fleet management system is configured to associate captured vehicle telematics data with captured service data based on the contextual attributes of each, such as the time, date, and location of data capture. By synching the vehicle telematics data to the service data, the operational data can be uniquely assessed for various operational efficiencies.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for segmenting operational data and identifying events of interested in the segmented operational data. With the events of interest identified from the segmented operational data, a total time between the events of interest can be determined, evaluated, and provided.

Abstract: Various embodiments of the present invention are directed to a mapping management computer system. According to various embodiments, the mapping management computer system may be configured for updating geographical maps by assessing map data and operational data including vehicle telematics data to identify portions of a vehicle path that do not correspond to known travel paths. In various embodiments, the system is configured to define these identified portions as new known travel paths corresponding to a public road, private road, parking lot lane, or the like, and update the map data to reflect the new known travel paths.

Abstract: Methods for the use of peroxyacid for enhancing downstream processes through the enhanced removal of fine particulates from petroleum oils and refinery feedstocks and/or streams are disclosed. The methods beneficially minimize fouling and improve waste water quality. Methods for mitigating heavy metal concentrations in petroleum oil and for preventing solid loading in various streams resulting from use of a metal based H2S scavenger, aluminum and/or zinc salts, or other commonly applied metal-based additives are also disclosed. In addition, methods for enhancing coke quality by the contaminant removal, reducing bacteria in slop oil and crude tanks, as well as reducing downstream catalyst poisoning and prolonging catalyst lifetimes are also disclosed. The compositions for use in the methods are provided.

Abstract: In a feedthrough device and method of assembly thereof, a body has longitudinally spaced first and second end faces and an inner surface defining a longitudinally extending opening. A conductor extends within the opening and an insulator extends within the opening transversely intermediate the conductor and the inner surface of the body to insulate the conductor from the body. The body has at least one indentation formed longitudinally into at least one of the first and second end faces, with a portion of the inner surface of the body being displaced transversely against the insulator in correspondence with the at least one longitudinal indentation to crimp the insulator and conductor within the opening of the body and maintain a hermetic seal across the feedthrough device.

Abstract: Provided is a detachable drum ammunition magazine for rimmed cartridges having a housing with a neck portion configured for detachable attachment to a firearm. A first sprocket in the housing has a first axis of rotation. A second sprocket within the first sprocket has an axis of rotation concentric with the first axis of rotation. The first sprocket has a gap through which cartridges are pushed to the neck portion and a hinged follower is on the second sprocket.

Abstract: Various embodiments of the present invention are generally directed to a systems and methods for assessing turns made by one or more vehicles. According to various embodiments, the system is configured to identify, based telematics data captured from the vehicles, turns executed by the vehicle during a particular time period. The system is further configured to analyze the identified turns to determine and display various turn segment attributes to a user in order to provide an indication of turns having an abnormal or excessive duration and/or to provide overall efficiency-indicative information relating to the vehicle turns.

Abstract: An apparatus and method for retrofitting a wired luminaire to wireless control. The method includes coupling a sensor and the luminaire to the controller by wire and further includes controlling a separate memory device, a radio, a relay for switching power to a luminaire, a zero to ten-volt luminaire control output, and a hardware switch with a single microcontroller.