Patents by Inventor J. Denry Sato

J. Denry Sato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybridomas producing monoclonal antibodies which specifically bind to continuous epitope on the human EGF receptor and compete with EGF for binding to the EGF receptor
    Patent number: 5459061
    Abstract: Hybridomas producing monoclonal antibodies that specifically bind to the human EGF receptor and compete with EGF for binding to the EGF receptor are described. The subject monoclonal antibodies bind to an epitope located between residues Ala-351 and Asp-364 of the EGF receptor, which is not denatured by boiling, treatment with detergent or treatment with a reducing agent.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: October 17, 1995
    Assignee: W. Alton Jones Cell Science Center, Inc.
    Inventors: J. Denry Sato, Dianging Wu, Lihua Wang
  • Method for the isolation of hybridomas using cholesterol auxotrophy of myeloma cells
    Patent number: 5110737
    Abstract: Cholesterol auxotrophy of myeloma cells is used as the basis for selecting hybridomas. The outgrowth of nascent hybridomas in a cholesterol-free medium was 3- to 9-fold more efficient than that in HAT medium and resulted in 3- to 13-times as many antigen-reactive hybridoma cells. This method of hybridoma selection can be applied with any sterol-dependent parent cell line. The nutrient medium is also preferably free of Ham's F-12 nutrient mixture.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: May 5, 1992
    Assignee: W. Alton Jones Cell Science Center Incorporated
    Inventors: Yoshinari Myoken, Tetsuji Okamoto, J. Denry Sato
  • Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
    Patent number: 4943533
    Abstract: Hybrid cell lines that synthesize and secrete monoclonal antibodies against epidermal growth factor receptor generated by the fusion of myeloma cells to lymphocytes immunized with epidermal growth factor receptor are disclosed. The method of generating the hybridomas, as well as therapeutic and diagnostic uses of the monoclonal antibodies in both cancer treatment and research are also disclosed.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: July 24, 1990
    Assignee: The Regents of the University of California
    Inventors: John Mendelsohn, Tomoyuki Kawamoto, Gordon Sato, J. Denry Sato