Patents by Inventor J. Edward Semple

J. Edward Semple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for treating influenza
    Patent number: 11850237
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: December 26, 2023
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR COMPOUNDS AND USES THEREOF
    Publication number: 20230293539
    Abstract: Described herein are phenyl triazole and aniline compounds that are MLL1-WDR5 protein-protein interaction inhibitors. Also disclosed herein are pharmaceutical compositions and methods of use for the phenyl triazole and the aniline compounds.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 21, 2023
    Inventors: Farbod SHOJAEI, Che FANG, J. Edward SEMPLE, Mireille GILLINGS
  • PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
    Publication number: 20230286925
    Abstract: Described herein are a phenyl triazole MLL1-WDR5 protein-protein interaction inhibitors, pharmaceutical compositions and methods of use.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 14, 2023
    Inventors: Qidong YOU, Xiaoke GUO, Farbod SHOJAEI, Xin CHEN, J. Edward SEMPLE, Zhengyu JIANG, Xiaoli XU, Mireille GILLINGS
  • HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
    Publication number: 20230286948
    Abstract: Described herein are a haloalkylpyridyl triazole MLL1-WDR5 protein-protein interaction inhibitors, pharmaceutical compositions and methods of use.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 14, 2023
    Inventors: Farbod SHOJAEI, J. Edward SEMPLE, Mireille GILLINGS
  • COMPOUNDS AND METHODS FOR TREATING INFLUENZA
    Publication number: 20210177809
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 17, 2021
    Applicant: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Compounds and methods for treating influenza
    Patent number: 10912768
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: February 9, 2021
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • COMPOUNDS AND METHODS FOR TREATING INFLUENZA
    Publication number: 20190307730
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 10, 2019
    Applicant: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Compounds and methods for treating influenza
    Patent number: 10363243
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: July 30, 2019
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • COMPOUNDS AND METHODS FOR TREATING INFLUENZA
    Publication number: 20180078533
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Application
    Filed: November 16, 2017
    Publication date: March 22, 2018
    Applicant: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Compounds and methods for treating influenza
    Patent number: 9820975
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: November 21, 2017
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • COMPOUNDS AND METHODS FOR TREATING INFLUENZA
    Publication number: 20160228415
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Application
    Filed: April 20, 2016
    Publication date: August 11, 2016
    Applicant: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Compounds and methods for treating influenza
    Patent number: 9345690
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: May 24, 2016
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • COMPOUNDS AND METHODS FOR TREATING INFLUENZA
    Publication number: 20150250768
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Application
    Filed: March 16, 2015
    Publication date: September 10, 2015
    Applicant: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Haloalkyl heteroaryl benzamide compounds
    Patent number: 9126992
    Abstract: A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: September 8, 2015
    Assignee: Romark Laboratories, L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Compounds and methods for treating influenza
    Patent number: 9023877
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: May 5, 2015
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Alkylsulfonyl-substituted thiazolide compounds
    Patent number: 8895752
    Abstract: A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: November 25, 2014
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • HALOALKYL HETEROARYL BENZAMIDE COMPOUNDS
    Publication number: 20140341850
    Abstract: A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
    Type: Application
    Filed: August 5, 2014
    Publication date: November 20, 2014
    Applicant: Romark Laboratories, L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Haloalkyl heteroaryl benzamide compounds
    Patent number: 8846727
    Abstract: A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: September 30, 2014
    Assignee: Romark Laboratories, L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Haloalkyl heteroaryl benzamide compounds
    Patent number: RE46724
    Abstract: A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: February 20, 2018
    Assignee: Romark Laboratories, L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Haloalkyl heteroaryl benzamide compounds
    Patent number: RE47786
    Abstract: A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: December 31, 2019
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple