Patents by Inventor Jüergen Siekmann

Jüergen Siekmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE
    Publication number: 20210163527
    Abstract: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
    Type: Application
    Filed: February 5, 2021
    Publication date: June 3, 2021
    Inventors: Stefan Haider, Andreas Ivens, Hanspeter Rottensteiner, Jüergen Siekmann, Peter Turecek, Oliver Zoechling