Abstract: Described are nucleotide sequences coding for and regulating expression of a cell cycle regulatory protein, designated p193, and recombinant vectors and host cells containing nucleotide sequences coding for and regulating expression of the protein sequence. Also described are methods for modifying the cell cycle of a cell by regulating p193 or its pathway. Methods for inducing apoptosis in cells are provided by increasing level of a pro-apoptotic p193 protein in the cells. Methods for suppressing apoptosis in or increasing the proliferative potential of cells are provided by reducing the level of pro-apoptotic p193 protein the cells and/or by interfering with the native p193 signal transduction pathway, for instance utilizing a p193 protein having a dominant negative mutation.

Abstract: The quick release canister supporting apparatus of the present invention includes a mounting bracket mountable to a rigid support, a rigid, canister retaining frame releasably mountable into mating engagement with the mounting bracket, and at least one latch cooperating between the mounting bracket and the retaining frame for the releasable mounting into mating engagement of the retaining frame with the mounting bracket. The latch may be mounted to the mounting bracket or to the retaining frame. A manually operable release actuator cooperates with the latch for selective actuation of the latch to release the retaining frame from the mounting bracket. The retaining frame defines a rigid cavity having an opening for receiving a gas canister substantially completely into the cavity. The retaining frame includes at least one selectively releasable canister rotation restraint for inhibiting rotation and sliding of the canister about and along its longitudinal axis.

Abstract: A flat panel display is based on a new switching technology for routing laser light among a set of optical waveguides and coupling that light toward the viewer. The switching technology is based on poled electro-optical structures. The display technology is versatile enough to cover application areas spanning the range from miniature high resolution computer displays to large screen displays for high definition television formats. The invention combines the high brightness and power efficiency inherent in visible semiconductor diode laser sources with a new waveguide electro-optical switching technology to form a dense two-dimensional addressable array of high brightness light emissive pixels.

Abstract: The invention provides an anticorrosive surface coating composition comprising a resin system, and a hydrophobic metal oxide. The hydrophobic metal oxide is characterized by being produced via a wet process and having a surface area of at least about 350 m2/g. The invention also provides a method of producing such an anticorrosive coating composition. The invention further provides a substrate having a surface coated with the surface coating composition of the invention, as well as a method of imparting corrosion resistance to a surface of a substrate.

Abstract: The invention provides a matt, thixotropic paint formulation comprising a resin system and a matting agent. The matting agent comprises a hydrophobic metal oxide, which has a surface moiety (i.e., one or more surface moieties) selected from the group consisting of trimethyl silyl, vinyl dimethyl silyl, acryl dimethyl silyl, and dimethyl silyl. Morever, the paint formulation is characterized by having thixotropic properties such that it does not sag at a notch height of about 75 &mgr;m when measured with an anti-sag meter after application to a substrate. The invention also provides a method of producing such a paint formulation. The invention further provides a substrate having a surface coated with the matt, thixotropic paint formulation of the invention.

Abstract: The present invention provides a surface coating composition comprising a resin, a hydrophobic metal oxide, and a carrier, wherein said composition, after application to a substrate, is characterized by moisture resistance, organic alcohol resistance, and a matting effect. In addition, the present invention provides a method of matting a surface coating composition and enhancing the moisture and chemical resistance of the composition, as well as a method of treating a substrate with the surface coating composition, and a substrate coated with such a surface coating composition.

Abstract: Described are methods in vitro and in vivo which involve the use of increased cyclin D2 activity to activate the cell cycle of cardiomyocytes as a baseline measure and/or in response to stimuli. Also described are vectors useful for these purposes, and cardiomyocyte cells exhibiting an activated cell cycle. Transgenic cyclin D2 animal models are also described.

Abstract: An optical assembly, such as a multiple output diode laser pump source for EDFAs, is formed by pressing an optical array emitter chip against a standoff structure protruding from a submount such that the emitter chip deforms to match the curvature of the standoff structure. An IO chip is also juxtaposed against the standoff structure such that its optical receivers can receive optical energy from the emitter chip. The IO chip can provide various optical functions, and then provide an optical array output for coupling into an optical fiber array. The standoff structure preferably contacts the emitter chip over an aggregate contact area much smaller than the area by which the emitter chip overlaps the submount. The materials used for bonding the emitter chip and the IO chip to the submount are disposed in the recesses between standoffs and not on the contact surfaces of the standoff structure.

Abstract: The present invention provides a recording medium comprising a substrate having a glossy coating thereon, wherein the glossy coating comprises cationic silica. The cationic silica comprises silica particles having a mean diameter of less than about 1 &mgr;m that have been contacted with at least one aluminum compound. The present invention also provides an aqueous dispersion of cationic silica, a coating composition comprising it, and methods of preparing the dispersion, coating composition, and recording medium.

Abstract: This invention provides a method of inhibiting in a mammal neurological damage resulting from impairment of glucose and/or oxygen supply to the brain, which method comprises administering to the mammal prior to the impairment of glucose and/or oxygen supply to the brain an amount of an NR2B subunit selective NMDA antagonist, which amount is effective in inhibiting neurological damage. This invention also provides a method of preventing primary hyperalgesia, secondary hyperalgesia, primary allodynia, secondary allodynia, or other pain caused by central sensitization, in a mammal, which method comprises administering to the mammal, prior to affliction with said pain, an amount of an NR2B subunit selective NMDA antagonist, which amount is effective in preventing said pain.

Abstract: Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the heart.

Abstract: The quick release canister supporting apparatus of the present invention includes a mounting bracket mountable to a rigid support, a rigid, canister retaining frame releasably mountable into mating engagement with the mounting bracket, and at least one latch cooperating between the mounting bracket and the retaining frame for the releasable mounting into mating engagement of the retaining frame with the mounting bracket. The latch may be mounted to the mounting bracket or to the retaining frame. A manually operable release actuator cooperates with the latch for selective actuation of the latch to release the retaining frame from the mounting bracket. The retaining frame defines a rigid cavity having an opening for receiving a gas canister substantially completely into the cavity. The retaining frame includes at least one selectively releasable canister rotation restraint for inhibiting rotation and sliding of the canister about and along its longitudinal axis.

Abstract: Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the heart.

Abstract: An integrated optical microstructure includes a substrate carrying an optical waveguide and supporting a medium disposed to receive optical energy from the waveguide. The medium includes an optical re-radiator such as a phosphor, which re-radiates optical energy in response to optical energy received from the waveguide. The structure further includes a reflector disposed to redirect some of the input optical energy emanating from the medium back into the medium, to achieve spatial confinement of the input light delivered by the input waveguide. The structure can thereby increase the efficiency of the light conversion processes of re-radiating materials. An aperture in the reflector permits optical energy emitted by the re-radiator to emerge from the structure and to propagate in a preferred direction, such as toward a viewer or sensor.

Abstract: Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the heart.

Abstract: An optical structure is fabricated by forming an active layer including a photodefinable material on a substrate or on another underlying layer, forming an upper layer above the active layer, and then patterning the active layer by selective application of radiation through the upper layer. The upper layer is substantially transparent to radiation of the type required to activate the photodefinable material in the active layer.

Abstract: Soft body armor has a ballistic panel having an interleaved construction of a generally vertically oriented plurality of layers of interleaved sheets or woven fiber cloth and sheets of cross plied unidirectional tape adjacently interleaved in an interleave ratio of plies of cross plied unidirectional tape to plies of woven fiber cloth within each layer of the plurality of layers, the plurality of layers forming a non-quilted array between a front face of the ballistic panel and a back face of the ballistic panel, wherein the interleave ratio of plies of cross plied unidirectional tape to plies of woven fiber cloth within each layer of the plurality of layers is between 1:1 and 4:4, and wherein the total number of the plies of cross plied unidirectional tape is equal to or greater than the total number of the plies of woven fiber cloth within the plurality of layers.

Abstract: An integrated optical microstructure includes a substrate carrying an optical waveguide and supporting a medium disposed to receive optical energy from the waveguide. The medium includes an optical re-radiator such as a phosphor, which reradiates optical energy in response to optical energy received from the waveguide. The structure further includes a reflector disposed to redirect some of the input optical energy emanating from the medium back into the medium, to achieve spatial confinement of the input light delivered by the input waveguide. The structure can thereby increase the efficiency of the light conversion processes of re-radiating materials. An aperture in the reflector permits optical energy emitted by the re-radiator to emerge from the structure and to propagate in a preferred direction, such as toward a viewer or sensor.

Abstract: One or more lasers are combined with optical energy transfer devices and energy guiding devices which use an electric field for control. The optical energy transfer devices may form gratings, mirrors, lenses and the like using a class of poled structures in solid material. The poled structures may be combined with waveguide structures. Electric fields applied to the poled structures control routing, reflection and refraction of optical energy. Adjustable tunability is obtained by a poled structure which produces a spatial gradient in a variable index of refraction along an axis in the presence of a variable electric field.

Abstract: Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the heart.