Patents by Inventor J. Flaherty

J. Flaherty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210100797
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Application
    Filed: October 6, 2020
    Publication date: April 8, 2021
    Applicant: Purdue Research Foundation
    Inventors: Daniel P. Flaherty, Richard M. van Rijn, Val J. Watts, Jason A. Scott
  • Patent number: 10959774
    Abstract: An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: March 30, 2021
    Assignee: Fractyl Laboratories, Inc.
    Inventors: Christopher J. Kadamus, Mark A. Manasas, Andrew Coats, Jay Caplan, Harith Rajagopalan, R. Maxwell Flaherty, J. Christopher Flaherty
  • Publication number: 20210085390
    Abstract: An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.
    Type: Application
    Filed: December 3, 2020
    Publication date: March 25, 2021
    Applicant: Fractyl Laboratories, Inc.
    Inventors: Christopher J. Kadamus, Mark A. Manasas, Andrew Coats, Jay Caplan, Harith Rajagopalan, R. Maxwell Flaherty, J. Christopher Flaherty
  • Patent number: 10926710
    Abstract: A carrier rack mountable to a vehicle includes a splined member, a first arm rotationally coupled about the splined member, and a latch coupled to the first arm. The splined member includes a plurality of splines disposed along an external surface of the splined member. The splined member is disposed through an aperture in a proximal end of the first arm. The latch is configured to engage the splined member to fix the first arm about the splined member.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: February 23, 2021
    Assignee: Thule Sweden AB
    Inventors: Keith L. Prescott, John D. Fiegener, Joseph R. Flaherty, Thomas J. Hanson, Timothy J. Makris, Michael Tinstman
  • Publication number: 20210000423
    Abstract: The present invention includes systems, devices and methods for treating and/or diagnosing a heart arrhythmia, such as atrial fibrillation. Specifically, the present invention provides a system including a diagnostic catheter and an ablation catheter. The diagnostic catheter includes a shaft, multiple dipole mapping electrodes and multiple ultrasound transducers. The ablation catheter is slidingly received by the diagnostic catheter shaft.
    Type: Application
    Filed: April 29, 2020
    Publication date: January 7, 2021
    Inventors: Randell L. Werneth, Graydon E. Beatty, Timothy J. Corvi, J. Christopher Flaherty, Marcus Frederick Julian
  • Publication number: 20200398055
    Abstract: A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided.
    Type: Application
    Filed: January 24, 2020
    Publication date: December 24, 2020
    Applicant: Functional Neuromodulation, Inc.
    Inventors: J. Christopher Flaherty, Daniel J. O'Connell, Todd Langevin, R. Maxwell Flaherty
  • Patent number: 10850358
    Abstract: A spindle locking apparatus for power tools having a spindle mounted for rotation within a tubular housing. The locking apparatus includes a locking sleeve disposed between the spindle and its tubular housing, a locking collar surrounding the tubular housing radially outboard of the locking sleeve, and a set of drive pins mechanically coupling the locking collar to the locking sleeve through axial slots in the tubular collar. The inner periphery of the locking sleeve is shaped to lockingly engage a flat-sided portion of the spindle, and a spring element biases the locking sleeve away from the flat-sided portion of the spindle to unlock the spindle. The locking collar is axially shiftable against the spring bias as permitted by the slots in the tubular housing to bring the locking sleeve into locking engagement with the flat-sided portion of the spindle to prevent spindle rotation.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: December 1, 2020
    Assignee: G.A.W. Inc.
    Inventors: Robert Arthur, Nathaniel P Wenzel, Nicholas J Russell, Michael J Flaherty
  • Publication number: 20200352439
    Abstract: Provided are a localization system and method useful in the acquisition and analysis of cardiac information. The localization system and method can be used with systems that perform cardiac mapping, diagnosis and treatment of cardiac abnormalities, as examples, and in the retrieval, processing, and interpretation of such types of information. The localization system and method use high impedance inputs, improved isolation, and relatively high drive currents for pairs of electrodes used to establish a multi-axis coordinate system. The axes can be rotated and scaled to improve localization.
    Type: Application
    Filed: April 15, 2020
    Publication date: November 12, 2020
    Inventors: Daniel J. Welsh, Marcus F. Julian, Graydon E. Beatty, Xinwei Shi, Derrick R. Chou, Randell L. Werneth, J. Christopher Flaherty, Mark MacGregor
  • Publication number: 20200305972
    Abstract: An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Applicant: Fractyl Laboratories, Inc.
    Inventors: Christopher J. Kadamus, Mark A. Manasas, Andrew Coats, Jay Caplan, Harith Rajagopalan, R. Maxwell Flaherty, J. Christopher Flaherty
  • Patent number: 10787439
    Abstract: N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: September 29, 2020
    Assignees: UNIVERSITY OF KANSAS, THE REGENTS OF THE UNIVERSITY OF MICHIGAN, SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, WAYNE STATE UNIVERSITY
    Inventors: Jennifer E. Golden, Jeffrey Aube, Daniel P. Flaherty, Andrew M. Fribley, Randal J. Kaufman, Thomas D. Y. Chung, Anthony B. Pinkerton, Michael Pablo Hedrick
  • Patent number: 10765474
    Abstract: An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: September 8, 2020
    Assignee: Fractyl Laboratories, Inc.
    Inventors: Christopher J. Kadamus, Mark A. Manasas, Andrew Coats, Jay Caplan, Harith Rajagopalan, R. Maxwell Flaherty, J. Christopher Flaherty
  • Publication number: 20200276013
    Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.
    Type: Application
    Filed: May 18, 2020
    Publication date: September 3, 2020
    Inventors: Jeffrey W. Chambers, Gregory G. Brucker, Joseph P. Higgins, Saravana B. Kumar, Jason S. Diedering, Karl A. Kabarowski, Robert J. Thatcher, James E. Flaherty, Jeffrey R. Stone
  • Publication number: 20200239447
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Application
    Filed: April 3, 2020
    Publication date: July 30, 2020
    Applicant: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel Patrick Flaherty, Jatinder Kaur
  • Publication number: 20200237494
    Abstract: A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
    Type: Application
    Filed: September 20, 2019
    Publication date: July 30, 2020
    Inventors: Mohammed S. El-Kurdi, William R. Wagner, David A. Vorp, John J. Stankus, Lorenzo Soletti, Jonathan McGrath, Yi Hong, J. Christopher Flaherty
  • Publication number: 20200222179
    Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.
    Type: Application
    Filed: March 31, 2020
    Publication date: July 16, 2020
    Inventors: Jeffrey W. Chambers, Gregory G. Brucker, Joseph P. Higgins, Saravana B. Kumar, Jason S. Diedering, Karl A. Kabarowski, Robert J. Thatcher, James E. Flaherty, Jeffrey R. Stone
  • Publication number: 20200222117
    Abstract: A robotic introducer system comprises a first assembly comprising a cable control assembly configured for use in a plurality of medical procedures, a second assembly comprising a distal link extension assembly configured for fewer uses than the first assembly, and a third assembly comprising an articulating probe assembly, coupled between the first and second assemblies and configured for fewer uses than the second assembly.
    Type: Application
    Filed: September 16, 2019
    Publication date: July 16, 2020
    Inventors: Brett Zubiate, Thomas J. Calef, Gabriel A. Johnston, Ian Joseph Darisse, Michael S. Castro, Arnold Oyola, Kevin Gilmartin, Joseph A. Stand, III, R. Maxwell Flaherty, J. Christopher Flaherty
  • Publication number: 20200171613
    Abstract: A spindle locking apparatus for power tools having a spindle mounted for rotation within a tubular housing. The locking apparatus includes a locking sleeve disposed between the spindle and its tubular housing, a locking collar surrounding the tubular housing radially outboard of the locking sleeve, and a set of drive pins mechanically coupling the locking collar to the locking sleeve through axial slots in the tubular collar. The inner periphery of the locking sleeve is shaped to lockingly engage a flat-sided portion of the spindle, and a spring element biases the locking sleeve away from the flat-sided portion of the spindle to unlock the spindle. The locking collar is axially shiftable against the spring bias as permitted by the slots in the tubular housing to bring the locking sleeve into locking engagement with the flat-sided portion of the spindle to prevent spindle rotation.
    Type: Application
    Filed: November 30, 2018
    Publication date: June 4, 2020
    Applicant: G.A.W. INC
    Inventors: ROBERT ARTHUR, NATHANIEL P WENZEL, NICHOLAS J RUSSELL, MICHAEL J FLAHERTY
  • Patent number: 10667753
    Abstract: The present invention includes systems, devices and methods for treating and/or diagnosing a heart arrhythmia, such as atrial fibrillation. Specifically, the present invention provides a system including a diagnostic catheter and an ablation catheter. The diagnostic catheter includes a shaft, multiple dipole mapping electrodes and multiple ultrasound transducers. The ablation catheter is slidingly received by the diagnostic catheter shaft.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: June 2, 2020
    Assignee: ACUTUS MEDICAL, INC.
    Inventors: Randell L. Werneth, Graydon E. Beatty, Timothy J. Corvi, J. Christopher Flaherty, Marcus Frederick Julian
  • Patent number: 10662176
    Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: May 26, 2020
    Assignee: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel P. Flaherty, Jatinder Kaur
  • Patent number: 10653318
    Abstract: Provided are a localization system and method useful in the acquisition and analysis of cardiac information. The localization system and method can be used with systems that perform cardiac mapping, diagnosis and treatment of cardiac abnormalities, as examples, and in the retrieval, processing, and interpretation of such types of information. The localization system and method use high impedance inputs, improved isolation, and relatively high drive currents for pairs of electrodes used to establish a multi-axis coordinate system. The axes can be rotated and scaled to improve localization.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: May 19, 2020
    Assignee: ACUTUS MEDICAL, INC.
    Inventors: Daniel J. Welsh, Marcus F. Julian, Graydon E. Beatty, Xinwei Shi, Derrick R. Chou, Randell L. Werneth, J. Christopher Flaherty