Abstract: Techniques and devices are described for generating modified audio signals. The techniques include receiving an audio signal at a device, tracking a movement of the device, generating a first modified audio signal to spatialize the audio signal, generating a second modified audio signal to spatialize the audio signal, causing the first modified audio signal to be rendered using a first speaker of the device, and causing the second modified audio signal to be rendered using a second speaker of the device. In some cases, the first modified audio signal is generated using a first head-related transfer function (HRTF) and the movement of the device, and the second modified audio signal is generated using a second HRTF and the movement of the device, where the second HRTF is different from the first HRTF. Numerous variations and configurations will be apparent in view of this disclosure.

Abstract: A lockbolt swage end effector incorporates a swage tool releasably engaged by a connector assembly to hydraulic operator carried in a frame. A two piece core-bolt operably connects the swage tool and the hydraulic operator through the connector assembly. A connection flange attaches the frame to a mating flange on a robotic manipulator.

Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low.

Abstract: This disclosure relates to methods for detection and measurement of anti-drug antibodies (ADAs) against Factor XI and/or Factor XIa therapeutic antibodies, e.g., in a subject being treated with said Factor XI and/or Factor XIa therapeutic antibodies.

Abstract: Provided herein are methods of treating cancer in a human subject, comprising administering to the subject: i) an antibody-drug conjugate (ADC) comprising an antibody, a cleavable linker and a cytotoxic agent, and ii) a bispecific checkpoint inhibitor. Further provided herein are kits comprising i) an antibody-drug conjugate (ADC) comprising an antibody, a cleavable linker and a cytotoxic agent, and ii) a bispecific checkpoint inhibitor.

Abstract: A method, composition and kit for the treatment of fibrotic lung disease are disclosed. The method utilizes a combination product for inhalation comprising a therapeutic amount of a dry powder formulation provided in an inhaler to be administered to a subject in need by oral inhalation. The composition comprise diketopiperazine particles for pulmonary inhalation.

Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as low.

Abstract: A turbine shroud assembly includes a carrier segment, a blade track segment, and a retainer. The carrier segment is formed to include an attachment-receiving space. The blade track segment includes a shroud wall and attachment flanges that extends radially outward from the shroud wall into the attachment-receiving space of the carrier segment. The retainer couples the blade track segment to the carrier segment.

Abstract: A turbine section of a gas turbine engine includes a case, a plurality of flow path components, and a mounting system. The case extends circumferentially at least partway around an axis of the gas turbine engine. The plurality of flow path components includes a flow path segment and a turbine vane. The mounting system couples the flow path segment to the case to support the flow path segment radially relative to the axis of the gas turbine engine.

Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low.

Abstract: A heat shield assembly adapted for use with gas turbine engines, airframes, and aircraft includes a carrier and a heat-shield tile. The carrier is adapted to couple to the gas turbine engine, airframe, or aircraft. The heat-shield tile includes material different than the carrier and is arranged to cover the carrier to protect the carrier from high-temperature gases surrounding the heat shield assembly.

Abstract: An audio system, method, and computer program product which includes a wearable audio device and a peripheral device. Each device is capable of determining its respective absolute or relative position and orientation. Once the relative positions and orientations between the devices are known, virtual sound sources are generated at fixed positions and orientations relative to the peripheral device such that any change in position and/or orientation of the peripheral device produces a proportional change in the position and/or orientation of the virtual sound sources. Additionally, first order and second order reflected audio paths may be simulated for each virtual sound source to increase the realism of the simulated sources. Each sound path can be produced by modifying the original audio signal using head-related transfer functions (HRTFs) to simulate audio as though it were perceived by the user's left and right ears as coming from each virtual sound source.

Abstract: A turbine shroud assembly includes a carrier assembly, a blade track segment, a retainer, and a clip shim. The carrier assembly is arranged circumferentially at least partway around an axis. The blade track segment is supported by the carrier assembly to locate the blade track segment radially outward of the axis and define a portion of a gas path of the turbine shroud assembly. The retainer extends into the carrier assembly and the blade track segment. The clip shim is located between the carrier assembly and the blade track and configured to urge the blade track segment axially toward the carrier assembly.

Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as low.

Abstract: Provided herein are methods of treating cancer in an individual that has failed an anti-PD1/PD-L1 therapy, comprising selecting an individual that has failed a prior anti-PD1/PD-L1 therapy; and administering to the individual a first agent that blocks or disrupts PD-L2, RGMb, or a combination thereof, and a second agent that blocks or disrupts PD-L1, PD-1 or a combination thereof. Also provided herein are kits and therapeutic compositions for use in the methods described herein.

Abstract: The present invention is based, in part, on the discovery of monoclonal and polyclonal antibodies that specifically bind to phosphorylated PD-1, as well as immunoglobulins, polypeptides, nucleic acids thereof, and methods of using such antibodies for diagnostic, prognostic, and therapeutic purposes.

Abstract: A turbine shroud assembly adapted for use with a gas turbine engine includes a carrier, a seal segment, and a mount assembly. The carrier is configured to be coupled to a turbine case. The seal segment is shaped to define a gas path boundary of the shroud assembly. The mounting assembly is configured to couple the seal segment to the carrier.

Abstract: The present disclosure provides methods of administering bispecific antibodies and antigen-binding fragments thereof that specifically bind to human Programmed cell-death-1 (PD-1) and Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) to a subject in need thereof, for example, a subject with cancer.

Abstract: A turbine shroud assembly includes a carrier segment and a blade track segment. The carrier segment includes an outer wall, a first mount flange, and a second mount flange having a chordal seal. The blade track segment includes a shroud wall and an attachment feature. The mount assembly couples the blade track segment to the carrier segment.

Abstract: A turbine shroud assembly adapted for use with a gas turbine engine includes a shroud segment and a carrier. The shroud segment extends circumferentially partway around an axis to define a gas path boundary of the turbine shroud assembly. The carrier is configured to support the shroud segment in position radially relative to the axis.