Patents by Inventor J. Gabriel Michael

J. Gabriel Michael has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oral therapy for the treatment of allergies and method of manufacture
    Patent number: 6174529
    Abstract: An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process. In addition to being immunogenic, when administered orally, encapsulated allergen has a therapeutic effect in the treatment of human allergies.
    Type: Grant
    Filed: October 11, 1997
    Date of Patent: January 16, 2001
    Assignee: University of Cincinnati
    Inventors: J. Gabriel Michael, Allen Litwin
  • Oral administration of therapeutic proteins for treatment of autoimmune disease, transplant rejection and infectious disease
    Patent number: 5783193
    Abstract: An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 21, 1998
    Assignee: The University of Cincinnati
    Inventors: J. Gabriel Michael, Allen Litwin
  • Oral administration of therapeutic proteins for treatment of infectious disease
    Patent number: 5629001
    Abstract: An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: May 13, 1997
    Assignee: University of Cincinnati
    Inventors: J. Gabriel Michael, Allen Litwin
  • Oral administration of therapeutic proteins for treatment of infectious disease
    Patent number: 5609871
    Abstract: An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process.
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: March 11, 1997
    Inventors: J. Gabriel Michael, Allen Litwin
  • Oral administration of immunologically active biomolecules and other therapeutic proteins
    Patent number: 5591433
    Abstract: An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process. In addition to being immunogenic, when administered orally, encapsulated allergen has a therapeutic effect in the treatment of human allergies.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: January 7, 1997
    Assignee: University of Cincinnati
    Inventors: J. Gabriel Michael, Allen Litwin
  • Polypeptide active immunosuppressant fraction
    Patent number: 4469677
    Abstract: Immunosuppressive polypeptide fractions prepared by enzymatic digestion of specific allergens are non-reactive in animals and humans and effective by parenteral administration, the immunosuppression being antigen specific, affecting production of immunoglobulins. A method of producing immunosuppressive polypeptide fractions and a method of desensitizing mammals therewith are disclosed.
    Type: Grant
    Filed: June 30, 1982
    Date of Patent: September 4, 1984
    Inventors: J. Gabriel Michael, Amadeo J. Pesce