Abstract: An optical cannula system can include a cannula, a body, a first tube, a second tube, and a valve assembly. An outer cannula wall can define an interior space extending along an axis of the cannula. One or more inner cannula walls within the outer cannula wall can divide the interior space into a first channel and a second channel. A proximal portion of the cannula can be received within the body. The first and second tubes can extend from the body. The valve assembly can have a first configuration in which the first tube is in fluid communication with the first channel and the second tube is in fluid communication with the second channel. The valve assembly can have a second configuration in which the first tube is in fluid communication with the second channel and the second tube is in fluid communication with the first channel.

Abstract: A system including a processing circuit configured to collect at least first contact information of a beneficiary, identify a risk associated with the beneficiary, automatically calculate a risk score for an electronic transaction based on the risk, determine that the risk score exceeds a first threshold value and displaying a notification on the user device associated with the electronic transaction, receive data from the user device, wherein the data includes at least second contact information corresponding to the beneficiary, compare the first contact information and the second contact information with additional data, wherein comparing includes analyzing the call records or the emails and determining that a user conducted at least one mitigation activity of the displayed mitigation activities, recalculate the risk score based on the at least one mitigation activity, and display the recalculated risk score on the user device.

Abstract: This technology relates to polynucleotides comprising optimized FMR1 open reading frame (ORF) sequences, viral vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of FMR1, such as Fragile X syndrome (“FXS”).

Abstract: Provided herein are methods of producing a trained model for generating peptide or protein sequence information and infilling of targeted residue spans. In some embodiments, the methods include training a model using a training dataset comprising a population of reference amino acid sequence representations in which a given amino acid sequence representation in the population is conditioned on one or more conditioning tags that provide a controllable generation of selected amino acid sequence representation types. Related methods, systems, and computer program products are also provided.

Abstract: Implementations described herein are directed toward an improved orthopedic arthroscopy system that reduces the number of necessary arthroscopic portals while at the same time improving endoscopic visualization and instrumentation capability within the joint space. Main embodiments of the disclosed system replace the traditional rod endoscope with a rotatable, optical cannula through which instruments can be used to manipulate tissue and perform surgery. By adding the cannula rotation capability, visualization of instrument tool tip can be easily adjusted. The disclosed system would eliminate the need for unnecessary wrist rotation by the surgeon thereby making it easier to coordinate hand position while performing surgical tasks.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SURF1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a SURF1 polypeptide.

Abstract: A customer interfacing with a credential manager may be enabled to request and obtain securely from the credential manager additional details related to a service transaction previously effected between the customer and a service provider using a customer transaction credential managed by the credential manager. To obtain such a detailed customer receipt for presentation to a customer, the credential manager may provide an authenticatable customer receipt request to the service provider that may include certain information indicative of an active session between the credential manager and an authenticated customer and/or certain information indicative of a trusted relationship between the credential manager and service provider. When a request is authenticated, the service provider may provide a detailed customer receipt to the credential manager in a format that may be presented to the customer but that may not be used by the credential manager to easily access details conveyed by the receipt.

Abstract: A psoas stretching apparatus allows a user to release their tight psoas muscles. To help the user target difficult to reach psoas muscles that are otherwise ignored in conventional stretching regimens, the psoas stretching apparatus includes a ground engaging base connected to a pair of upwardly extending support structures. The pair of support structures, padding, and pin elements are configured to adjust the angle and height of a convex leg stabilization structure that supports and cradles the user's leg while providing leverage for the psoas stretch.

Abstract: A deflector is disclosed for deflecting air flow in a rotating electrical machine comprising a stator (8), stator windings (10) and a housing (12). The deflector comprises a sheet of material folded to form a deflecting portion (42) and a connecting portion (44). The deflecting portion (42) is arranged to deflect airflow from a gap (14) between the stator and the housing towards the stator windings (10). The connecting portion comprises one or more apertures (48; 52; 54; 56; 58) adjacent to the deflecting portion. The aperture helps to reduce or avoid the Coand{hacek over (a)} effect, and thereby improve the impingement of cooling air on the stator end windings.

Abstract: A tray system for robotic part processing is provided, comprising: a plurality of substantially identical trays, each including a base having an upper surface and a lower surface, a frame connected to the upper surface of the base and defining a plurality of pockets for receiving workpieces, and a plurality of spacers, each spacer including an alignment feature on the upper surface or the lower surface of the base, and at least one stacking post on another of the upper surface or the lower surface of the base of each of the plurality of trays, each stacking post including one end having a centering tip and another end configured to mate with another stacking post; wherein the trays are configured to be stacked in alignment with one another by placing the plurality of alignment features of one tray into engagement with the plurality of spacers of another tray.

Abstract: Provide herein are polynucleotides comprising a codon-optimized AP4M1 open reading frame (ORF) sequence encoding an AP4M1 polypeptide, vectors (viral or non-viral vectors) comprising the same, pharmaceutical compositions comprising the same, and methods of using the same for delivery of the polynucleotides to a cell or a subject and to treat AP4M1-related genetic disorders such as AP4M1 deficiency and spastic paraplegia type 50.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SLC6A1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a GAT1 polypeptide.

Abstract: A customer interfacing with a credential manager may be enabled to request and obtain securely from the credential manager additional details related to a service transaction previously effected between the customer and a service provider using a customer transaction credential managed by the credential manager. To obtain such a detailed customer receipt for presentation to a customer, the credential manager may provide an authenticatable customer receipt request to the service provider that may include certain information indicative of an active session between the credential manager and an authenticated customer and/or certain information indicative of a trusted relationship between the credential manager and service provider. When a request is authenticated, the service provider may provide a detailed customer receipt to the credential manager in a format that may be presented to the customer but that may not be used by the credential manager to easily access details conveyed by the receipt.

Abstract: The present disclosure provides methods and compositions for the treatment of Angelman Syndrome The methods and compositions of the present disclosure comprise isolated nucleic acid molecules, rAAV vectors and rAAV viral vectors comprising polynucleotide sequences encoding for short hairpin RNA (shRNA) molecules directed against UBE3A-ATS.

Abstract: An integral optical construction includes a lens layer including a structured first major surface having a plurality of microlenses. An optically opaque mask layer is disposed on the lens layer and defines a plurality of openings. Each of the openings extends from a first major surface of the mask layer facing the lens layer to an opposite second major surface of the mask layer. The openings are in a one-to-one correspondence with the microlenses. Regions of the mask layer between the openings have an optical density of greater than about 2 for at least a first visible wavelength in a visible wavelength range. An optical adhesive layer is disposed on, and makes physical contact with, the second major surface of the mask layer. The optical adhesive layer defines a recess at each of the openings. The recess includes a closed bottom and an opposite open top open to the opening.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SLC6A1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a GAT1 polypeptide.

Abstract: An air-boom spreader has a hopper for containing particulate material, a metering device having a plurality of sluices, a plurality of outlets transversely spaced-apart on a boom in a direction perpendicular to the direction of travel of the spreader, and a plurality of air lines connecting the plurality of sluices to the plurality of outlets for conveying the particulate material in an air stream from the plurality of sluices to the plurality of outlets. The spreader has more than twice as many outlets as sluices, and the plurality of outlets has an innermost outlet, an outermost outlet and at least three other outlets between the innermost outlet and the outermost outlet whereby each of the innermost outlet and the outermost outlet are supplied with half as much of the particulate material as each of the at least three other outlets.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to MeCP2 loss and/or misfunction, including RETT syndrome. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a MeCP2 polypeptide.

Abstract: An optical stack for sensing a presence of an analyte is provided. The optical stack includes a sensor material. The sensor material includes a first optical response including a first optical property having a second value in response to an excitation signal including the first optical property having a first value different from the second value. The first optical response includes a second optical property sensitive to the presence of the analyte. The optical stack includes a first optical film disposed proximate the sensor material and includes a third optical property having respective third and fourth values in response to the respective first and second values of the first optical property. The third value is different from the fourth value by at least a factor of 2.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and/or disorders in a subject, including, but not limited to neurological disorders such as giant axonal neuropathy. The methods described herein include direct administration of a gene therapy (e.g. an rAAV viral vector) to a subject via injection into a vagus nerve (e.g. the left vagus nerve) of the subject.