Patents by Inventor J. Gregory Zeikus

J. Gregory Zeikus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermotoga neapolitana xylose isomerase polypeptides and nucleic acids encoding same
    Publication number: 20030166172
    Abstract: The present invention provides novel isolated polynucleotides encoding a novel xylose isomerases capable of catalyzing the conversion of glucose to fructose and nucleic acids encoding for such isomerase. The present invention also provides a method of producing the xylose isomerase enzymes employing DNA encoding for the enzymes, plasmids containing the DNA, and bacteria into which the plasmids have been inserted and which produce the enzymes.
    Type: Application
    Filed: January 21, 2003
    Publication date: September 4, 2003
    Applicant: Board of Trustees of MICHIGAN STATE UNIVERSITY
    Inventors: J. Gregory Zeikus, Dinlaka Sriprapundh, Claire Vieille
  • Glucose isomerases with improved affinity for D-glucose
    Patent number: 5266475
    Abstract: A genetically engineered glucose isomerase with improved affinity for D-glucose and the method of preparation of such a glucose isomerase are disclosed. The glucose isomerase is obtained by mutagenizing the gene of a naturally occurring glucose isomerase such that a smaller amino acid replaces a larger amino acid in the catalytic site. In an especially advantageous embodiment of the present invention, the Clostridium glucose isomerase sequence is mutated and the residue replaced with a smaller amino acid is either Trp.sub.139 or Val.sub.186.
    Type: Grant
    Filed: September 19, 1991
    Date of Patent: November 30, 1993
    Assignee: Michigan Biotechnology Institute
    Inventors: Chanyong Lee, Michael Bagdasarian, J. Gregory Zeikus, Menghsiao Meng