Patents by Inventor J. Grimaldi

J. Grimaldi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRO9925 POLYPEPTIDES
    Publication number: 20070238859
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: August 13, 2002
    Publication date: October 11, 2007
    Inventors: Kevin Baker, Luc Desnoyers, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Victoria Smith, Jean-Philippe Stephan, Colin Watanabe, William Wood
  • SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME
    Publication number: 20070207147
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: October 24, 2006
    Publication date: September 6, 2007
    Applicant: Genentech, Inc.
    Inventors: Kevin Baker, Luc Desnoyers, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Victoria Smith, Jean-Philippe Stephan, Colin Watanabe, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20070191270
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: September 22, 2005
    Publication date: August 16, 2007
    Inventors: Kevin Baker, Dan Eaton, Ellen Filvaroff, Audrey Goddard, J. Grimaldi, Austin Gurney, Victoria Smith, Jean Stephan, Colin Watanabe, William Wood, Zemin Zhang, Sherman Fong
  • NUCLEIC ACID ENCODING NOVEL TYPE-1 CYTOKINE RECEPTOR GLM-R
    Publication number: 20070174922
    Abstract: The present invention is directed to novel polypeptides having sequence similarity to Interleukin 6 receptor and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: February 24, 2003
    Publication date: July 26, 2007
    Inventors: Nico Ghilardi, Frederic de Sauvage, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, William Wood
  • Method of Diagnosing and Treating Cartilaginous Disorders
    Publication number: 20070160594
    Abstract: The present invention is directed to novel polypeptides having sequence similarity to human inter-alpha-trypsin inhibitor and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods of using the polypeptide to diagnose and treat damage to cartilage resulting from injury and/or cartilaginous disorders.
    Type: Application
    Filed: December 18, 2006
    Publication date: July 12, 2007
    Inventors: Ellen Filvaroff, J. Grimaldi, William Wood, Audrey Goddard
  • Novel polypeptides having sequence similarity to GDNFR and nucleic acids encoding the same
    Publication number: 20070154475
    Abstract: The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: February 20, 2007
    Publication date: July 5, 2007
    Inventors: J. Grimaldi, Somasekar Seshagiri, Jeremy Stinson, William Wood, Zemin Zhang
  • NOVEL TYPE-1 CYTOKINE RECEPTOR GLM-R
    Publication number: 20070136829
    Abstract: The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided are methods for detecting agents that modulate the activity of GLM-R. Also provided are methods for diagnosing and for treating disorders characterized by the over or under abundance of monocytes or macrophages.
    Type: Application
    Filed: October 11, 2006
    Publication date: June 14, 2007
    Inventors: Nico Ghilardi, Frederic De Sauvage, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, William Wood
  • Interleukin-8 homologous polypeptides and therapeutic uses thereof
    Publication number: 20070025962
    Abstract: The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
    Type: Application
    Filed: September 28, 2006
    Publication date: February 1, 2007
    Inventors: Dan Eaton, Dorothy French, J. Grimaldi, Kenneth Hillan, Maria Pisabarro, Kerstin Schmidt, Victoria Smith, Daniel Tumas, Richard Vandlen, Colin Watanabe, P. Williams, William Wood
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20070020735
    Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Application
    Filed: September 29, 2006
    Publication date: January 25, 2007
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gumey, Kenneth Hillan, Sarah Hymowitz, Hanzhong Li, James Pan, Melissa Starovasnik, Daniel Tumas, Menno Lookeren, Richard Vandlen, Colin Watanabe, P. Williams, William Wood, Daniel Yansura
  • Nucleic acid underexpressed in melanoma
    Publication number: 20070003935
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: April 7, 2005
    Publication date: January 4, 2007
    Inventors: Dan Eaton, Ellen Filvaroff, Mary Gerrilsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Colin Watanabe, William Wood
  • Interleukin-8 homologous polypeptides and therapeutic uses thereof
    Publication number: 20060210991
    Abstract: The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
    Type: Application
    Filed: March 9, 2004
    Publication date: September 21, 2006
    Inventors: Dan Eaton, Dorothy French, J. Grimaldi, Kenneth Hillan, Maria Pisabarro, Kerstin Schmidt, Victoria Smith, Daniel Tumas, Richard Vandlen, Colin Watanabe, P. Williams, William Wood
  • Novel composition and methods for the treatment of immune disorders
    Publication number: 20060210556
    Abstract: The present invention relates to compositions of matter and methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation of T-cells in either the Th1 subtype or the Th2 subtype based on the relative expression levels of the gene PRO92726, and its agonists or antagonists. The present invention further relates to a method of diagnosing Th1- and Th2-mediated diseases.
    Type: Application
    Filed: April 8, 2004
    Publication date: September 21, 2006
    Applicant: Genentech, Inc.
    Inventors: Daryl Baldwin, Hilary Clark, Henry Chiu, Grazyna Fedorowicz, Sherman Fong, J. Grimaldi, Wenjun Quyang, P. Williams
  • PR1550 polypeptides and nucleic acids encoding the same
    Publication number: 20060177897
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 27, 2005
    Publication date: August 10, 2006
    Applicant: Genentech, Inc.
    Inventors: Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Colin Watanabe, William Wood
  • Nucleic acid underexpressed in stomach tumor and lung tumor
    Publication number: 20060160186
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: March 14, 2006
    Publication date: July 20, 2006
    Inventors: Dan Eaton, Ellen Filvaroff, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Colin Watanabe, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060127983
    Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 6, 2005
    Publication date: June 15, 2006
    Inventors: Kevin Baker, David Botstein, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Mary Napier, Margaret Roy, Daniel Tumas, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060105427
    Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 6, 2005
    Publication date: May 18, 2006
    Inventors: Kevin Baker, David Botstein, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Mary Napier, Margaret Roy, Daniel Tumas, William Wood
  • Antibodies to a polypeptide encoded by a nucleic acid underexpressed in melanoma
    Publication number: 20060099657
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: April 6, 2005
    Publication date: May 11, 2006
    Inventors: Dan Eaton, Ellen Filvaroff, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Colin Watanabe, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060078964
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: August 9, 2002
    Publication date: April 13, 2006
    Inventors: Avi Ashkenazi, Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Sophia Kuo, Mary Napier, James Pan, Nicholas Paoni, Margaret Roy, David Shelton, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060073552
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: September 12, 2002
    Publication date: April 6, 2006
    Inventors: Kevin Baker, Dan Eaton, Ellen Filvaroff, Audrey Goddard, J. Grimaldi, Austin Gurney, Victoria Smith, Jean Stephan, Colin Watanabe, William Wood, Zemin Zhang, Sherman Fong
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060073549
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: September 13, 2002
    Publication date: April 6, 2006
    Inventors: Kevin Baker, Dan Eaton, Ellen Filvaroff, Audrey Goddard, J. Grimaldi, Austin Gurney, Victoria Smith, Jean Stephan, Colin Watanabe, William Wood, Zemin Zhang, Sherman Fong