Abstract: Controlled-release dosage forms comprising opioid agonist and opioid antagonist are provided. The dosage forms release the opioid antagonist and the opioid agonist in a controlled-release manner. The dosage forms may be used to provide pain relief to patients while reducing the side effects associated with opioid agonists.

Abstract: Controlled-release dosage forms comprising opioid agonist and opioid antagonist are provided. The dosage forms release the opioid antagonist and the opioid agonist in a controlled-release manner. The dosage forms may be used to provide pain relief to patients while reducing the side effects associated with opioid agonists.

Abstract: Disclosed is an oral dosage form comprising (i) an opioid agonist in releasable form and (ii) a sequestered opioid antagonist which is substantially not released when the dosage form is administered intact, such that the ratio of the amount of antagonist released from said dosage form after tampering to the amount of said antagonist released from said intact dosage form is about 4:1 or greater, based on the in-vitro dissolution at 1 hour of said dosage form in 900 ml of Simulated Gastric Fluid using a USP Type II (paddle) apparatus at 75 rpm at 37 degrees C. wherein said agonist and antagonist are interdispersed and are not isolated from each other in two distinct layers.

Abstract: This invention is a reinforced ventilated shoe. It is formed with a strip of shoe cover material circumscribing the toe, sole, arch and heel. Reinforcing strips are provided to form an ankle band and parallel instep strips which extend from the toe portion to the ends of the ankle band. A vertically disposed strip connect the heel portion of the circumscribing strip and the back of the ankle band. Side strips connect the ankle band at one end and the other ends of the side strips are bifurcated below the ankle bone and connect the arch portion of the sole at spaced points. Other strips are provided connecting the parallel instep strips and the sole portion of the circumscribing strip; and strips horizontally disposed connecting the parallel instep strips and the vertically disposed strip at the heel. The shoe is provided with air penetratable netting in the spaces between the strips.