Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.

Abstract: The present invention relates to polynucleotide molecules for regulating gene expression in plants. In particular, the invention relates to promoters that are useful for regulating gene expression of heterologous polynucleotide molecules in plants. The invention also relates to expression constructs and transgenic plants containing the heterologous polynucleotide molecules.

Abstract: The present invention relates to polynucleotide molecules for regulating gene expression in plants. In particular, the invention relates to promoters that are useful for regulating gene expression of heterologous polynucleotide molecules in plants. The invention also relates to expression constructs and transgenic plants containing the heterologous polynucleotide molecules.

Abstract: A method of controlling traction in a vehicle having at least one non-driven wheel speed sensor. Actual vehicle acceleration and a wheel speed difference are detected. At least one of the actual vehicle acceleration and the wheel speed difference is compared to at least one of a predetermined vehicle acceleration and a predetermined wheel speed difference to detect vehicle wheel slip. A wheel torque is reduced in response to detected wheel slip. The foregoing method allows traction control to be installed in many types of vehicles, including vehicles without ABS. More than one type of wheel slip detection can be implemented, and various types of wheel slip can be detected.

Abstract: A manipulator for servicing tubes extending through a tube sheet having three major components: a base member, a block member, and a foot member. The base member has a holder for supporting tooling or inspection devices. The base member also has at least one gripper for releasably gripping a tube extending through the tube sheet. The block member is connected to the base member for linear movement and rotation relative to the base member. The foot member is connected to the block member for linear movement relative to the block member. The foot member has at least one, and preferably two grippers, for releasably gripping a tube extending through the tube sheet. The manipulator supports itself using the two sets of expandable and translatable grippers that anchor into the tube ends and can move from tube to tube by alternately engaging each set of grippers.

Abstract: The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

Abstract: A feedthrough apparatus for a implantable medical device having a casing includes a conductive housing having an outer side, an inner side, and a peripheral surface with a continuous assembly groove therein for mounting on the casing of the implantable medical device. The conductive housing has first and second through bores extending between the outer side and the inner side in spaced apart, generally parallel, relationship. First and second filtered feedthrough assemblies are received, respectively, in the first and second through bores. Each filtered feedthrough assembly includes an insulative terminal, a filter capacitor, and a plurality of lead wires electrically isolated from the conductive housing supported on and extending through the insulative terminal and through the filter capacitor in conductive relation therewith. Also, a backfill port is provided on the conductive housing and has a passageway extending between the inner side and the outer side.

Abstract: The invention provides a device and technique to seal an annular defect of an intervertebral disc, determine the in-situ volume of nucleus pulposus material removed, for example from a discectomy of a herniated disc, and facilitate injection of nuclear replacement material.

Abstract: An implantable cardiac system has a master pacing unit and a remote satellite pacing unit. The master pacing unit is electrically coupled to a right side of a patient's heart via a lead assembly. The satellite pacing unit is a leadless device mounted on the left side of the patient's heart and is wirelessly controlled by the master pacing unit. The satellite pacing unit is affixed to the heart by one or more mounting members. The base of the satellite unit case has a gel-like material which facilitates adhesion of the pacing unit to the heart tissue. The gel-like material promotes tissue growth to hold the pacing unit in place on the heart. The gel-like material may be composed of polyvinlpyrrolidone and may contain a steroid, such as dimethyl sulfoxide (DMSO), or dexamethazone sodium phosphate.

Abstract: The present invention includes an intervertebral prosthetic disc, a method for installing a plate into an intervertebral space, and a method for installing a prosthetic disc into an intervertebral space. The intervertebral prosthetic disc can include a superior endplate and an inferior endplate, wherein at least one of the superior endplate and the inferior endplate is adapted to receive a guidewire. In the methods for installing a plate into an intervertebral space and for installing a prosthetic disc into an intervertebral space, a guidewire is used to facilitate installing plates onto vertebral bone endplates.