Abstract: Disclosed is a compound of formula (I), in which R1, R2, R3, R4, R5, X1, X2, X3, X4, and X5 are described herein. The small molecule compounds of formula (I) activate the functional activity of relaxin family peptide receptor 2 (RXFP2), thereby providing therapeutic treatments for a variety of disorders, such as a bone disorder, hypogonadism, cryptorchidism, polycystic ovary syndrome, cancer, infertility, or an ocular wound.

Abstract: The disclosure provides methods for carrying out Real Time Cellular Thermal Shift Assays (RT-CETSA). Also provided are molecular constructs and protein constructs for use in such assays and devices suitable for carrying out such assays. Also provided are non-parametric methods for analyzing data from RT-CETSA and other biological target engagement assays.

Abstract: Systems and methods provide real-time shipping optimization recommendations for reducing the cost of shipping freight units in a shipment. System comprises a measurement system in communication with a computer system that comprises a client computer device in communication with a host computer system. The measurement system comprises multiple sensing devices, including a plurality of Light Detection and Ranging (LIDAR) cameras, to determine weight, dimensions, and other shipping parameters of the freight units in the shipment. The computer system computes a current shipping cost and density based on the shipping parameters. The computer system determines shipping recommendations including recommended adjustments to the shipping parameters that reduce the current shipping cost. The shipping recommendations are transmitted to the client computer device prior to loading the shipment onto a carrier vehicle for the shipment.

Abstract: A vehicle safety restraint provides a harness for two persons, seated inline, as upon a motorcycle, all-terrain vehicle, snowmobile, personal watercraft and the like. The harness has a forward portion, generally worn by the operator, and a rearward portion, generally worn by the passenger. The forward and rearward portions are connected by horizontally positioned straps and have vertically positioned straps for securing each portion over the torso and shoulders and away from the necks of the operator and of the passenger. A spreader maintains the straps in an X like arrangement and has a construction comfortable upon the back of a passenger. The straps are connected by quick releases, or buckles, at key junctions and have adjustors that permit length adjustments of the straps, making them suitable for persons seated upright safely upon a vehicle.

Abstract: The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for dynamic rerouting of uniform resource identifiers having different syntaxes. A method includes a server receiving from a computing device a request that includes an initial uniform resource identifier (URI) that includes a product identifier. The request can be generated by the user scanning a product tag. Based on the identifier, the server finds two or more routing policy entries associated with the product. Each policy entry can include a regular expression that specifies syntax for parsing the initial URI and at least one variable. The server eliminates any routing policy having a context specification that does not match the request's context information and any routing policy entries having a regular expression that does not match the initial URI. The server composes a target URI based on a remaining routing policy entry and redirects the computing device to the target URI.

Abstract: A heat exchanger comprising a matrix with an interior and an exterior. The matrix has an input face and an output face and one or more exterior surfaces that span between the input face and the output face. The primary media flows between the input face and the output face. The heat exchanger has a decongealing path that spans from an inlet across an entire length of the input face, spans the one or more exterior surfaces that span between the input face and the output face, and spans an entire length of the exterior output face to the outlet.

Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: Systems and methods provide real-time shipping optimization recommendations for reducing the cost of shipping freight units in a shipment. System comprises a measurement system in communication with a computer system that comprises a client computer device in communication with a host computer system. The measurement system comprises multiple sensing devices to determine weight, dimensions, and other shipping parameters of the freight units in the shipment. The computer system computes a current shipping cost and density based on the shipping parameters. The computer system determines shipping recommendations including recommended adjustments to the shipping parameters that reduce the current shipping cost. The shipping recommendations are transmitted to the client computer device prior to loading the shipment onto a carrier vehicle for the shipment.

Abstract: Systems and methods for operating an antenna with a tension cord network coupled to a plurality of anchor points of a perimeter hoop structure. The methods comprise: using the tension cord network to support a flexible antenna reflector surface such that a given shape of the flexible antenna reflector surface is provided; and allowing locations of the anchor points to change relative to the tension cord network while the antenna is in use. The flexible antenna reflector surface is held taut when the locations of the anchor points change relative to the tension cord network.

Abstract: The invention includes remote-participation of a medical device manufacturing company representative in a medical procedure, whereby the device representative uses a variety of components including a surgical grid with multiple indicators for medical objects to track and monitor devices in an operating room in “real-time,” while checking on device status and advising a surgeon through Wearable Video Technology rather than being physically present in the operating room.

Abstract: Perimeter truss reflector includes a perimeter truss assembly (PTA) comprised of a plurality of battens, each having an length which traverses a PTA thickness as defined along a direction aligned with a reflector central axis. A collapsible mesh reflector surface is secured to the PTA such that when the PTA is in a collapsed configuration, the reflector surface is collapsed for compact stowage and when the PTA is in the expanded configuration, the reflector surface is expanded to a shape that is configured to concentrate RF energy in a predetermined pattern. Each of the one or more longerons extend around at least a portion of a periphery of the PTA. These longerons each comprise a storable extendible member (SEM) which can be flattened and rolled around a spool, but exhibits beam-like structural characteristics when unspooled.

Abstract: Disclosed are systems and methods utilize networked speaker arrays and audio waveform shaping using interferometric feedback of sound transmitted by the speaker arrays. In further aspects, the systems and method employ an intelligently controlled acoustic device that can focus sound at specific locations and record the acoustic environment/reflected sound to self-calibrate for improved performance. Moreover, the device is modular and scalable with the ability to network distributed speakers to enhance the audio performance.

Abstract: The disclosure provides methods for carrying out Real Time Cellular Thermal Shift Assays (RT-CETSA). Also provided are molecular constructs and protein constructs for use in such assays and devices suitable for carrying out such assays.

Abstract: Aspects of the present disclosure relate to methods and apparatuses for relofting nonwoven substrates. During the relofting process, a substrate is directed to advance in a first direction such that a length of the substrate is in a facing relationship with a radiation source. The advancing substrate is relofted by irradiating the length of the substrate with infrared radiation from the infrared radiation source. The substrate comprises a first caliper upstream of the radiation source and the substrate comprises a second caliper downstream of the radiation source greater than the first caliper. The substrate may also be redirected around an axis to advance the substrate in a second direction, wherein the second direction is different than the first direction. The axis may be selectively movable between a first position and a second position to selectively subject the substrate to infrared radiation and remove the substrate from the infrared radiation.

Abstract: The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

Abstract: A gas turbine power plant comprises a gas turbine, a power turbine, a clutch, an electrical generator and a controller. The power turbine is fluidly connected to the gas turbine without any mechanical connection. The clutch comprises an input mechanically connected to the power turbine and an output mechanically connected to the electric generator. The controller can identify that a speed of the electric generator is greater than a speed of the power turbine, determine a difference between the speed of the electric generator and the power turbine, in response to the difference being greater than a threshold, control the gas turbine to a first maximum acceleration of the power turbine, and in response to the difference being equal or less than to the threshold, control the gas turbine to a second maximum acceleration of the power turbine that is less than the first maximum acceleration.

Abstract: Systems and methods provide real-time shipping optimization recommendations for reducing the cost of shipping freight units in a shipment. System comprises a measurement system in communication with a computer system that comprises a client computer device in communication with a host computer system. The measurement system comprises multiple sensing devices to determine weight, dimensions, and other shipping parameters of the freight units in the shipment. The computer system computes a current shipping cost and density based on the shipping parameters. The computer system determines shipping recommendations including recommended adjustments to the shipping parameters that reduce the current shipping cost. The shipping recommendations are transmitted to the client computer device prior to loading the shipment onto a carrier vehicle for the shipment.