Patents by Inventor J. Hoekstra

J. Hoekstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metalloenzyme inhibitor compounds
    Patent number: 10370354
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: August 6, 2019
    Assignee: NQP 1598, LTD.
    Inventors: William J. Hoekstra, Christopher M. Yates
  • ANTIFUNGAL COMPOUNDS
    Publication number: 20190216087
    Abstract: The present invention relates to compounds of Formula (I): wherein R1 is as defined herein, or an acceptable salt, solvate, prodrug or hydrate thereof. The compounds of Formula I are inhibitors of metalloenzymes, such as lanosterol demethylase (CYP51).
    Type: Application
    Filed: May 17, 2016
    Publication date: July 18, 2019
    Applicant: Viamet Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Christopher M Yates, Robert J Schotzinger, Michael R LOsco, Gary D Gustafson, Michael T Sullenberger, Kimberly Steward, Javier Delgado, Xuelin Wang
  • ANTIFUNGAL COMPOUNDS AND PROCESSES FOR MAKING
    Publication number: 20190210994
    Abstract: The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: February 8, 2019
    Publication date: July 11, 2019
    Inventors: William J. Hoekstra, David Dale Wirth, Tracy Ehiwe, Thierry Bonnaud
  • Antifungal Compound Process
    Publication number: 20190194160
    Abstract: The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compounds 7, 7* and 11, 11* and substituted derivatives thereof.
    Type: Application
    Filed: September 16, 2016
    Publication date: June 27, 2019
    Inventors: David Dale WIRTH, Christopher M. YATES, William J. HOEKSTRA, Martin F. BINDL, Eduard HARTMANN
  • Antifungal Compound Process
    Publication number: 20190185429
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: February 20, 2019
    Publication date: June 20, 2019
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • Antifungal Compound Process
    Publication number: 20190185430
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: February 20, 2019
    Publication date: June 20, 2019
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • Antifungal Compound Process
    Publication number: 20190177298
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: September 17, 2018
    Publication date: June 13, 2019
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • Metalloenzyme Inhibitor Compounds
    Publication number: 20190169159
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: January 28, 2019
    Publication date: June 6, 2019
    Inventors: William J. Hoekstra, Robert J. Schotzinger, Stephen W. Rafferty
  • Antifungal Compound Process
    Publication number: 20190161469
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: January 7, 2019
    Publication date: May 30, 2019
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • Antifungal Compound Process
    Publication number: 20190161470
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: January 22, 2019
    Publication date: May 30, 2019
    Inventors: William J. HOEKSTRA, Christopher M. YATES
  • 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
    Patent number: 10301283
    Abstract: Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and 1-(2,4-difluorophenyl)-2,2-difluoro-2-(5-substituted-pyridin-2-yl)ethanones and processes for their preparation.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: May 28, 2019
    Assignee: Dow Agrosciences, LLC
    Inventors: William J. Hoekstra, Nakyen Choy, Carl DeAmicis, Daniel Knueppel, Jim Renga, Michael T. Sullenberger, Gregory Whiteker, Yuanming Zhu, Gary D. Gustafson
  • Dynamic thread execution arbitration
    Patent number: 10269088
    Abstract: A mechanism is described for facilitating thread execution arbitration for thread scheduling relating to graphics processors at computing devices. A method of embodiments, as described herein, includes assigning priority levels to threads based on stall signals communicated from the one or more shared function units to one or more execution units of a processor including a graphics processor, and selecting a first thread to be scheduled and a second thread to be ignored based on the stall signals.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: April 23, 2019
    Assignee: INTEL CORPORATION
    Inventors: Joydeep Ray, Abhishek R. Appu, Subramaniam M. Maiyuran, Eric J. Hoekstra, Prasoonkumar Surti, Balaji Vembu, Altug Koker
  • Frequent data value compression for graphics processing units
    Patent number: 10262388
    Abstract: A control surface tracks an individual cacheline in the original surface for frequent data values. If so, control surface bits are set. When reading a cacheline from memory, first the control surface bits are read. If they happen to be set, then the original memory read is skipped altogether and instead the bits from the control surface provide the value for the entire cacheline.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: April 16, 2019
    Assignee: Intel Corporation
    Inventors: Saurabh Sharma, Abhishek Venkatesh, Travis T. Schluessler, Prasoonkumar Surti, Altug Koker, Aravindh V. Anantaraman, Pattabhiraman P. K., Abhishek R. Appu, Joydeep Ray, Kamal Sinha, Vasanth Ranganathan, Bhushan M. Borole, Wenyin Fu, Eric J. Hoekstra, Linda L. Hurd
  • Intelligent graphics dispatching mechanism
    Patent number: 10235736
    Abstract: An apparatus to facilitate data intelligent dispatching is disclosed. The apparatus includes one or more processing units including a plurality of execution units (EUs) to execute a plurality of processing threads and collection logic to collect statistics data for threads executed at the processing unit during execution of an application, and dispatch logic to dispatch the threads to be executed at a subset of the plurality of EUs during a subsequent execution of the application based on the statistics data.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: March 19, 2019
    Assignee: INTEL CORPORATION
    Inventors: Balaji Vembu, Murali Ramadoss, Guei-Yuan Lueh, Subramaniam M. Maiyuran, Abhishek R. Appu, Joydeep Ray, Altug Koker, James A. Valerio, Eric J. Hoekstra, Arthur D. Hunter, Jr.
  • Metalloenzyme inhibitor compounds
    Patent number: 10221160
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: March 5, 2019
    Assignee: Mycovia Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Robert J. Schotzinger, Stephen W. Rafferty
  • Antifungal compound process
    Patent number: 10196375
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: February 5, 2019
    Assignee: MYCOVIA PHARMACEUTICALS, INC.
    Inventors: William J. Hoekstra, Christopher M. Yates
  • METALLOENZYME INHIBITOR COMPOUNDS
    Publication number: 20190016700
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: December 29, 2016
    Publication date: January 17, 2019
    Inventors: Christopher M. Yates, Sammy R. Shaver, William J. Hoekstra
  • ANTIFUNGAL COMPOUND PROCESS
    Publication number: 20190010140
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: July 9, 2018
    Publication date: January 10, 2019
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • METALLOENZYME INHIBITOR COMPOUNDS
    Publication number: 20190008861
    Abstract: Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: September 7, 2018
    Publication date: January 10, 2019
    Inventors: Steven Sparks, Christopher M. Yates, Sammy R. Shaver, William J. Hoekstra
  • Antifungal compound process
    Patent number: 10173998
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: January 8, 2019
    Assignees: Mycovia Pharmaceuticals, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry