Patents by Inventor J. Keith Joung

J. Keith Joung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for interaction trap assays
    Patent number: 7029847
    Abstract: The present invention provides methods and compositions for interaction trap assays for detecting protein-protein, protein-DNA, or protein-RNA interactions. The methods and compositions of the invention may also be used to identify agents which may agonize or antagonize a protein-protein, protein-DNA, or protein-RNA interaction. In certain embodiments, the interaction trap system of the invention is useful for screening libraries with greater than 107 members. In other embodiments, the interaction trap system of the invention is used in conjunction with flow cytometry. The invention further provides a means for simultaneously screening a target protein or nucleic acid sequence for the ability to interact with two or more test proteins or nucleic acids.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: April 18, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: J. Keith Joung, Jeffrey Miller, Carl O. Pabo
  • Methods and compositions for interaction trap assays
    Publication number: 20040146931
    Abstract: The present invention provides methods and compositions for interaction trap assays for detecting protein-protein, protein-DNA, or protein-RNA interactions. The methods and compositions of the invention may also be used to identify agents which may agonize or antagonize a protein-protein, protein-DNA, or protein-RNA interaction. In certain embodiments, the interaction trap system of the invention is useful for screening libraries with greater than 107 members. In other embodiments, the interaction trap system of the invention is used in conjunction with flow cytometry. The invention further provides a means for simultaneously screening a target protein or nucleic acid sequence for the ability to interact with two or more test proteins or nucleic acids.
    Type: Application
    Filed: March 16, 2004
    Publication date: July 29, 2004
    Applicant: Massachusetts Institute of Technology
    Inventors: J. Keith Joung, Jeffrey Miller, Carl O. Pabo
  • Methods and compositions for interaction trap assays
    Publication number: 20030044787
    Abstract: The present invention provides methods and compositions for interaction trap assays for detecting protein-protein, protein-DNA, or protein-RNA interactions. The methods and compositions of the invention may also be used to identify agents which may agonize or antagonize a protein-protein, protein-DNA, or protein-RNA interaction. In certain embodiments, the interaction trap system of the invention is useful for screening libraries with greater than 107 members. In other embodiments, the interaction trap system of the invention is used in conjunction with flow cytometry. The invention further provides a means for simultaneously screening a target protein or nucleic acid sequence for the ability to interact with two or more test proteins or nucleic acids.
    Type: Application
    Filed: May 16, 2001
    Publication date: March 6, 2003
    Inventors: J. Keith Joung, Jeffrey Miller, Carl O. Pabo
  • Methods and compositions for interaction trap assays
    Publication number: 20020119498
    Abstract: The present invention provides methods and compositions for interaction trap assays for detecting protein-protein, protein-DNA, or protein-RNA interactions. The methods and compositions of the invention may also be used to identify agents which may agonize or antagonize a protein-protein, protein-DNA, or protein-RNA interaction. In certain embodiments, the interaction trap system of the invention is useful for screening libraries with greater than 107 members. In other embodiments, the interaction trap system of the invention is used in conjunction with flow cytometry. The invention further provides a means for simultaneously screening a target protein or nucleic acid sequence for the ability to interact with two or more test proteins or nucleic acids.
    Type: Application
    Filed: November 14, 2001
    Publication date: August 29, 2002
    Inventors: J. Keith Joung, Jeffrey Miller, Carl O. Pabo
  • Intraction trap assay, reagents and uses thereof
    Patent number: 5925523
    Abstract: The present invention makes available an interaction trap system (hereinafter "ITS") which is derived using recombinantly engineered prokaryotic cells.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: July 20, 1999
    Assignee: President & Fellows of Harvard College
    Inventors: Simon Dove, J. Keith Joung, Ann Hochschild