Abstract: A computerized system is disclosed for performing various medical diagnostic tests and evaluating the results thereof. In one form, image data generated from an imaging device, such as a CAT, PET, or MRI scanner, is analyzed by computer and compared with coded information defining past images of the same patient and/or standard images in order to assess the patient's condition. The system may incorporate various types of both imaging and non-imaging modalities for providing data inputs which are stored in a database for analysis. In one particular embodiment, a computer automatically controls the performance of certain tests in accordance with its evaluation of the current input data.

Abstract: A method and apparatus are disclosed for the in vivo transfer of therapeutic genes to internal body sites. An operating head of a catheter or endoscope contains a particle bombardment device for accelerating DNA-coated particles into a target tissue. With either endoscopy or arterial catheterization, the operating head may be guided to diseased or deficient organs, or other lesions, and deliver the gene coated particles in a targeted manner. In one embodiment, a double balloon catheter is employed to isolate an intravasular space containing the lesion to be treated, with the space being cleared of blood and filled with gas before operation of the particle bombardment device. The method and apparatus may also be employed to deliver other therapeutic agents to intracellular targets.

Abstract: A catheter device for performing atherectomy procedures and the like in which cutting blades at the distal end of the catheter are extended by the application of fluid pressure to the catheter to inflate a balloon. One or more cutting blades are attached to the end of a resilient support that maintains the blade in a retracted position until engaged by the expanding balloon to extend the blade radially outward. Specific embodiments include separate expandable balloons provided on each side of the cutting blade to isolate the operative site and separate conduits for the infusion of a flushing liquid to the operative site.