Abstract: Provided herein are asphalt compositions comprising asphalt, a carboxylated copolymer, a polyalkyleneimine, and a photoinitiator. The carboxylated copolymer present in the asphalt compositions can be a latex composition derived from a carboxylated styrene-butadiene copolymer. The carboxylated copolymer includes from 0.5% to 25% by weight carboxylic acid monomers. The carboxylated styrene-butadiene polymer and the asphalt can be present in a weight ratio of from 1:99 to 1:10. The polyalkyleneimine present in the asphalt compositions can be in an amount of greater than 0% to up to 10% by weight of the asphalt composition. The photoinitiator can include benzophenone and/or a derivative thereof. Tack coats meeting ASTM-D-977 standard comprising the asphalt compositions disclosed herein are also provided. The tack coat can have a tack-free time of 10 minutes or less. Methods of producing the asphalt compositions and tack coats are also disclosed.

Abstract: Disclosed herein are asphalt compositions containing a block-copolymer additive, for example for use as a dispersant. In some embodiments, the asphalt compositions can include asphalt, a block-copolymer dispersant, and an SBR latex. The block-copolymers have a molecular weight exceeding 5000 g/mol with a polybutyl acrylate hydrophobic block that attaches to the asphalt particle and a sodium polystyrene sulfonate hydrophilic block for stability, wherein the block copolymer has a first block comprising of alkyl acrylate and a second block comprising units of an ethylenically unsaturated monomer with sulfonic acid groups. The asphalt compositions can include asphalt in an amount of from 50 wt. % to 95 wt. %, based on the weight of the asphalt composition. In some embodiments, the asphalt compositions can include a styrene-butadiene copolymer in an amount of from 0.05 wt. % to 10 wt. %, based on the weight of the asphalt composition. Methods of making and using the asphalt compositions are also disclosed.

Abstract: Methods of treating a tumor in a subject and methods of determining a treatment regimen for a subject with a tumor are provided herein. In exemplary aspects, the methods comprise measuring the level of expression of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof. In exemplary aspects, the subject is a subject from which a sample was obtained, wherein the level of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof, has been measured from the sample. Related kits, computer readable-storage media, systems, and methods implemented by a processor in a computer are further provided.

Abstract: Asphalt emulsions comprising asphalt present in an amount of 50% by weight or greater, based on the weight of the asphalt emulsion, an isocyanate present in an amount of 0.05% by weight or greater, based on the weight of the asphalt emulsion, and water. The isocyanate is derived from an aromatic, a cycloaliphatic, or an aliphatic isocyanate, or a mixture thereof. Preferably, the isocyanate includes methylene diphenyl diisocyanate. The asphalt emulsion can comprise one or more polyols. Methods of making the asphalt emulsions are also described.

Abstract: A vibration isolator and method of assembly utilize “flex circuits” to provide both vibration/shock isolation and integrated electrically isolated conductive paths to support lightweight devices (<100 grams) such as crystal oscillators, IC chips, MEMs devices and the like. Each flex circuit includes a least one polymer layer and at least one of the flex circuits includes at least one patterned conductive layer. The isolator may be integrally formed from a stack of polymer layers and patterned conductive layers to provide the plurality of flex circuits, platform and connectors. Most typically, flex circuits are Type 4 in which the multiple polymer layers have a loose leaf or bonded configuration. Flex circuits are easy to produce in large quantities at low cost with standardized and repeatable performance characteristics.

Abstract: A clamping and locking device that uses two main parts. The two parts are connected by an axle, which acts as a fulcrum. The assembled clamp has jaws that meet together on one end of the assembled parts. There is a multi-radius latching system on the inside of the handle arms located on the other side of the axle. The handle arms may be straight or curved. The ends of the handle arms can be straight, or have hooks, ring-holes, hand-grips, or an assortment of other useful end-of-handle designs.

Abstract: This disclosure provides methods of treating a cancer in a patient using a peptide epoxyketone proteasome inhibitor in combination with a PIM kinase inhibitor.

Abstract: Electronic modules having complex contact structures may be formed by encapsulating panels containing pluralities of electronic modules delineated by cut lines and having conductive interconnects buried within the panel along the cut lines. Holes defining contact regions along the electronic module sidewall may be cut into the panel along the cut lines to expose the buried interconnects. The panel may be metallized, e.g. by a series or processes including plating, on selected surfaces including in the holes to form the contacts and other metal structures followed by cutting the panel along the cut lines to singulate the individual electronic models. The contacts may be located in a conductive grove providing a castellated module.

Abstract: A vibration isolator and method of assembly utilize “flex circuits” to provide both vibration/shock isolation and integrated electrically isolated conductive paths to support lightweight devices (<100 grams) such as crystal oscillators, IC chips, MEMs devices and the like. Each flex circuit includes a least one polymer layer and at least one of the flex circuits includes at least one patterned conductive layer. The isolator may be integrally formed from a stack of polymer layers and patterned conductive layers to provide the plurality of flex circuits, platform and connectors. Most typically, flex circuits are Type 4 in which the multiple polymer layers have a loose leaf or bonded configuration. Flex circuits are easy to produce in large quantities at low cost with standardized and repeatable performance characteristics.

Abstract: Methods of treating a tumor in a subject and methods of determining a treatment regimen for a subject with a tumor are provided herein. In exemplary aspects, the methods comprise measuring the level of expression of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof. In exemplary aspects, the subject is a subject from which a sample was obtained, wherein the level of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof, has been measured from the sample. Related kits, computer readable-storage media, systems, and methods implemented by a processor in a computer are further provided.

Abstract: A financial analysis system retrieves data from a myriad of public and/or private data sources to develop a financial model that takes into account many life situations that an individual may experience. Together with detailed information regarding the individual such as age, race/ethnic background, marital status, occupation, family information, health data, career data, place of living/work, expected future expenditures, goals, lifestyles, etc. From these, the financial analysis system predicts future financial situations such as savings/assets, cash flow, etc., based upon the individual's data in view of the myriad of data sources that are available, providing a more accurate view of what the future financial situation shall be for that individual.

Abstract: An asphalt composition comprising 0.1 to 8 wt.-% based on the total weight of the composition of an Isocyanate as thermosetting reactive compound and 0.1 to 8 wt.-% based on the total weight of the composition of a polymer selected from the group consisting of styrene/butadiene/styrene copolymer (SBS), styrene butadiene rubber (SBR), neoprene, polyethylene, low density polyethylene, oxidized high density polyethylene, polypropylene, oxidized high density polypropylene, maleated polypropylene, ethylene-butyl-acrylate-glycidyl-methacrylate terpolymer, ethyl vinyl acetate (EVA) and polyphosphoric acid (FRA).

Abstract: Provided herein are asphalt compositions comprising asphalt, a carboxylated copolymer, a polyalkyleneimine, and a photoinitiator. The carboxylated copolymer present in the asphalt compositions can be a latex composition derived from a carboxylated styrene-butadiene copolymer. The carboxylated copolymer includes from 0.5% to 25% by weight carboxylic acid monomers. The carboxylated styrene-butadiene polymer and the asphalt can be present in a weight ratio of from 1:99 to 1:10. The polyalkyleneimine present in the asphalt compositions can be in an amount of greater than 0% to up to 10% by weight of the asphalt composition. The photoinitiator can include benzophenone and/or a derivative thereof. Tack coats meeting ASTM-D-977 standard comprising the asphalt compositions disclosed herein are also provided. The tack coat can have a tack-free time of 10 minutes or less. Methods of producing the asphalt compositions and tack coats are also disclosed.

Abstract: Methods of treating a tumor in a subject and methods of determining a treatment regimen for a subject with a tumor are provided herein. In exemplary aspects, the methods comprise measuring the level of expression of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof. In exemplary aspects, the subject is a subject from which a sample was obtained, wherein the level of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof, has been measured from the sample. Related kits, computer readable-storage media, systems, and methods implemented by a processor in a computer are further provided.

Abstract: Methods of treating a tumor in a subject and methods of determining a treatment regimen for a subject with a tumor are provided herein. In exemplary aspects, the methods comprise measuring the level of expression of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof. In exemplary aspects, the subject is a subject from which a sample was obtained, wherein the level of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof, has been measured from the sample. Related kits, computer readable-storage media, systems, and methods implemented by a processor in a computer are further provided.

Abstract: This disclosure provides methods of treating a cancer in a patient using a peptide epoxyketone proteasome inhibitor in combination with a PIM kinase inhibitor.

Abstract: The invention provides combination therapy, wherein one or more other therapeutic agents are administered agents are administered with peptide epoxyketones or a pharmaceutically acceptable salt thereof. Another aspect of the invention relates to treating cancer with a peptide epoxyketone administered in combination with another therapeutic agent.

Abstract: A system includes a payload ejector configured to contact a payload carried by a flight vehicle and to push the payload away from the flight vehicle. The payload ejector includes a piston configured to extend from the payload ejector and a shock attenuator coupled to the piston, where the shock attenuator is configured to push the payload away from the flight vehicle. The shock attenuator includes a shock attenuator housing and a plunger that is movable within the shock attenuator housing and that extends from the shock attenuator housing. The plunger is configured to be pushed at least partially into the shock attenuator housing in order to damp a shock pulse applied to the payload. The shock attenuator housing may have an interior space, and the shock attenuator may further include a spring, compliant material, or fluid within the interior space.

Abstract: A system includes a payload ejector configured to contact a payload carried by a flight vehicle and to push the payload away from the flight vehicle. The payload ejector includes a piston configured to extend from the payload ejector and a shock attenuator coupled to the piston, where the shock attenuator is configured to push the payload away from the flight vehicle. The shock attenuator includes a shock attenuator housing and a plunger that is movable within the shock attenuator housing and that extends from the shock attenuator housing. The plunger is configured to be pushed at least partially into the shock attenuator housing in order to damp a shock pulse applied to the payload. The shock attenuator housing may have an interior space, and the shock attenuator may further include a spring, compliant material, or fluid within the interior space.

Abstract: Methods of treating a tumor in a subject and methods of determining a treatment regimen for a subject with a tumor are provided herein. In exemplary aspects, the methods comprise measuring the level of expression of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof. In exemplary aspects, the subject is a subject from which a sample was obtained, wherein the level of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof, has been measured from the sample. Related kits, computer readable-storage media, systems, and methods implemented by a processor in a computer are further provided.