Patents by Inventor J. Lefebvre

J. Lefebvre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11980662
    Abstract: Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: May 14, 2024
    Assignee: FluGen, Inc.
    Inventors: Matthew Frederick LeFebvre, Yasuko Hatta, Pamuk Bilsel, Michael J. Moser
  • Patent number: 9503467
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for determining network related anomaly scores. One of the methods includes generating a network map including at least a plurality of network nodes and a plurality of edges that indicate communications paths between the plurality of network nodes, obtaining first data indicating network activity over the edges and between the plurality of network nodes for a first time period, generating a model of expected network activity over the edges and between the plurality of network nodes for a future time period using the network map and the first data, obtaining second data indicating network activity over the edges and between the plurality of network nodes for a second time period, and determining an anomaly score using a comparison between the second data and the model of expected network activity.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: November 22, 2016
    Assignee: Accenture Global Services Limited
    Inventors: Michael J. Lefebvre, Matthew Carver, Eric Ellett, Walid Negm, Louis William DiValentin, James J. Solderitsch
  • Publication number: 20060202689
    Abstract: A method of eddy current testing without the need for lift-off compensation. Signal response features similar to those used in pulsed eddy current techniques are applied to conventional (harmonic) eddy current methods. The described method provides advantages in terms of data storage, since only two response parameters, the amplitude and phase, are sufficient to reconstruct any sinusoidal signal, therefore allowing for scanning of large surfaces.
    Type: Application
    Filed: March 10, 2006
    Publication date: September 14, 2006
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: J. Lefebvre, Catalin Mandache
  • Patent number: 5513526
    Abstract: The present invention relates to measuring device for measuring a component f a force acting on a test body, such as a hydrofoil, positioned within a testing apparatus. The measuring device has a test body formed by a foil shaped center section and two adjacent end sections. Each end section is joined to the center section by a flexure member having sufficient stiffness so that there is negligible relative motion between the center section and the end sections as a fluid medium flows past the center section. At least one strain gauge is mounted to at least one flexure member to measure the forces acting on the center section. A method for measuring the load on a test body is also described.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: May 7, 1996
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Paul J. Lefebvre, William P. Barker
  • Patent number: 5320485
    Abstract: A fluid cooled guide vane is disclosed for use in a gas turbine engine which defines a plurality of separate cooling circuits to guide a cooling fluid through the interior of the vane, while at the same time minimizing the pressure drop of the cooling fluid as it passes through the vane. Each cooling circuit has a cooling fluid inlet, a cooling fluid outlet, a cavity and a chamber which is in fluid communication with the cavity and either the fluid cooling inlet, or the fluid cooling outlet. The multiple chambers are located in mounting bases attached at either end of the vane. The mounting bases define the several chambers as well as the cooling fluid inlets. The cooling fluid outlets may either be defined by the mounting bases, or may be formed by rows of orifices through the vane wall in communication with the cavities within the vane.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: June 14, 1994
    Assignee: Societe Nationale d'Etude et de Construction de Moteurs d'Aviation (S.N.E.C.M.A.)
    Inventors: Anne E. F. Bourguignon, Jacques A. A. Boury, Philippe J. Lefebvre
  • Patent number: 5307688
    Abstract: An electromagnetic flowmeter and a method for measurement of the rate of flow of a fluid under unsteady conditions are described. It uses fluid steady-state flowmeter technology and a new algorithm to measure transient rate of flow of a fluid such as water. The algorithm teaches (a) measuring the e.m.f. generated due to the rate of flow of the fluid under test moving through a tube placed in an area with uniform magnetic flux, and (b) comparing it to a simultaneously generated reference signal which is measure of the magnetic flux density generated when an electromagnetic flowmeter is energized due to the fluid flow rate at the instant of taking the flow rate data of the fluid.
    Type: Grant
    Filed: December 24, 1990
    Date of Patent: May 3, 1994
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Paul J. Lefebvre
  • Patent number: 5231883
    Abstract: An apparatus for defining the free surface of a moving column of a fluid in vertical pipe to enhance the accuracy of measurements of transient rate of flow of the fluid using electromagnetic flowmeter is described. It provides a neutrally buoyant plug which stays in contact with the free surface of the column of the fluid at all times and thus defines the free surface of the fluid moving in the vertical pipe accurately and reduces the oscillations of the free surface of the fluid.
    Type: Grant
    Filed: December 24, 1990
    Date of Patent: August 3, 1993
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Paul J. Lefebvre, William W. Durgin
  • Patent number: 5205162
    Abstract: A facility for permitting launch performance tests to be conducted on an erwater vehicle, such as a torpedo, includes a housing having an opening therethrough defining a tubular chamber for receiving a vehicle therein. A piston is also positioned within the tubular chamber. A link disposed between the piston and the vehicle has a pair of opposing end portions connected with the piston and the vehicle, respectively. A channel is positioned adjacent to the housing and has water flowing therein at a predetermined velocity. The water within the channel communicates with the tubular chamber to allow water flowing within the channel to enter the tubular chamber and surround the vehicle with the vehicle at its rest position. A drive device is operable to move the piston through the tubular chamber a preselected distance sufficient to move the vehicle and the water surrounding the vehicle out of the tubular chamber and into the channel.
    Type: Grant
    Filed: October 5, 1992
    Date of Patent: April 27, 1993
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Paul J. Lefebvre, John A. Schwemin
  • Patent number: 5078009
    Abstract: A system is described for testing a pump or a turbine impeller under transient operating conditions in a fluid flow. The system provides simultaneously, as a function of time, user defined impeller speeds, fluid flow rate and rise in fluid pressure so as to simulate real conditions. This information can be used to analyze the performance of existing impellers or for designating new impellers.
    Type: Grant
    Filed: December 24, 1990
    Date of Patent: January 7, 1992
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Paul J. Lefebvre
  • Patent number: 4773817
    Abstract: The adjustment of clearances at the time of assembly and subsequently during operation of a labyrinth seal lying between the rotor and stator of a turbomachine is effected by radial displacements of a bush radially rigid with an outer pivot pin of each blade of the stator and co-operates with a boss of the casing by means of screw-threads. Such displacements are controlled as a function of a signal provided by a computer which integrates various operational parameters of the turbomachine and acts on a control ring connected by a lever to the said bush. The internal pivot of the blade is rigid with an annular member which carries a layer of abradable material constituting a fixed part of the labyrinth seal. The rotary part of the labyrinth seal is mounted on an opposed part of the rotor. A method for effecting the adjustment of the clearances is also described.
    Type: Grant
    Filed: August 26, 1987
    Date of Patent: September 27, 1988
    Assignee: Societe Nationale d'Etude et de Construction de Moteurs d'Aviation "S.N.E.C.M.A."
    Inventors: Gerard Stangalini, Philippe J. Lefebvre
  • Patent number: 4662821
    Abstract: Apparatus associated with a labyrinth seal of a turbo machine for automatically maintaining a desired clearance between lip members and a wear seal of the labyrinth seal over a range of operational states of the turbo machine. The wear seal comprises a first part made of honeycomb material and a second smooth part spaced axially from the first part. An annular carrier supports the wear seal, and a stator supports the carrier, thereby defining between the carrier and the stator an annular chamber having radially outer orifices for admission of an air supply to the chamber. An annular sheet member disposed within the annular chamber has a plurality of holes and is spaced at a small distance from the carrier. Whereas acceleration and deceleration of the turbo machine normally would tend to alter the spacing of the wear seal and the lip members, the structure recited above corrects for this effect, thereby maintaining a desired clearance between the wear seal and the lip members.
    Type: Grant
    Filed: September 26, 1985
    Date of Patent: May 5, 1987
    Assignee: Societe Nationale d'Etude et de Construction de Moteur d'Aviation S.N.E.C.M.A.
    Inventors: Robert Kervistin, Philippe J. Lefebvre, Alain F. Teissier
  • Patent number: 4380935
    Abstract: A vortex-sensing fluid flowmeter has a freely rotatable vortex-shedding body suspended in a section of conduit through which a fluid stream passes, the body being oriented generally transverse to the direction of fluid flow. The body has an integrally formed upstream-facing portion adapted to shed a series of vortices within the fluid, which vortices alternately influence opposite lateral faces of the body, tending to produce a periodic rotation of the body about a firmly attached rotational shaft. The shaft is rotatably mounted to the conduit and passes at one end through the wall of the conduit to the exterior thereof. A sleeve-like tube surrounds the shaft and is fastened tightly at its bottom end to the shaft and at its top end to the conduit wall to provide a fluid-tight seal around the shaft. The tube is sufficiently flexible and pliable to exert negligible restraining force against the rotation of the shaft.
    Type: Grant
    Filed: February 20, 1981
    Date of Patent: April 26, 1983
    Assignee: The Foxboro Company
    Inventors: George E. Sgourakes, Paul J. Lefebvre
  • Patent number: 4377289
    Abstract: An electric furnace electrode seal assembly includes a seal ring mounted on the furnace adjacent the electrode opening. The seal ring is stationary and supports a telescoping arrangement of a plurality of cylindrical sealing glands which can be air or convection cooled and extend upwardly along the electrode from the seal ring. The largest diameter gland can be located on top of the seal ring and the uppermost gland can be the smallest diameter and is supported by the electrode holder. Seals are interposed respectively between adjacent glands and these seals permit vertical telescopic movement as well as lateral movement of and slight tilting of the glands relative to each other. The bottom gland can slide on the seal ring to provide for additional lateral movement of the electrode and seal assembly. The assembly prevents leakage of gases and acts as a heat shield.
    Type: Grant
    Filed: December 18, 1981
    Date of Patent: March 22, 1983
    Assignee: Qit-Fer et Titane Inc.
    Inventor: Jean J. Lefebvre
  • Patent number: 4306726
    Abstract: An electric furnace electrode seal assembly includes a seal ring mounted on the furnace adjacent the electrode opening. The seal ring is stationary and supports a telescoping arrangement of a plurality of cylindrical water cooled sealing glands that extend upwardly along the electrode from the seal ring. The largest diameter gland can be located on top of the seal ring and the uppermost gland can be the smallest diameter and is supported by the electrode holder. Seals are interposed respectively between adjacent glands and these seals permit vertical telescopic movmeent as well as lateral movement of and slight tilting of the glands relative to each other. The bottom gland can slide on the seal ring to provide for additional lateral movement of the electrode and seal assembly. The assembly prevents leakage of gases and acts as a heat shield.
    Type: Grant
    Filed: April 22, 1980
    Date of Patent: December 22, 1981
    Assignee: Qit-Fer et Titane Inc.
    Inventor: Jean J. Lefebvre
  • Patent number: 4302286
    Abstract: A reactor vessel in-service inspection assembly (17) having an improved positioning device (80) for properly and repeatedly locating the inspection transducers (75) of the assembly within a hollow portion of the reactor vessel cavity. An acoustic transducer of the positioning device of this invention is affixed to the positioning arm (40) of the inspection transducers (75). The positioning transducer is operable to generate and simultaneously, radially direct acoustic signals around the circumference of the hollow portion of the vessel cavity and receive the signals reflected off of the cavity walls at a location within the hollow cavity. Means are provided for monitoring the received signals as a function of time. The in-service inspection assembly transducer positioning arm is arranged to automatically move in response to the monitored difference in the time of reception of the received signals to locate the positioning transducer at a preestablished location within the hollow portion of the reactor cavity.
    Type: Grant
    Filed: April 24, 1979
    Date of Patent: November 24, 1981
    Assignee: Westinghouse Electric Corp.
    Inventors: Bernard J. Lefebvre, William H. Krueger
  • Patent number: H1326
    Abstract: A system is described for providing means by which the flow in a fluid such s water in a fluid flow loop can be accurately controlled to undergo user defined transients. Besides, the system allows for velocity variations over a wide range of velocities.
    Type: Grant
    Filed: December 24, 1990
    Date of Patent: July 5, 1994
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Paul J. Lefebvre