Abstract: The invention provides CD27 agonists comprising a first component that is an anti-CD27 antibody, or antigen-binding fragment thereof, linked to a second component comprising one or more cross-linking moieties. At least one of the cross-linking moieties does not bind to an Fc receptor and the CD27 agonist stimulates T cell activity without the need for Fc receptor interaction. The cross-linking molecule(s) can be, for example, an anti-CD27, antibody, or antigen-binding fragment thereof, that can be the same or different than the first component. Alternatively, the cross-linking molecule(s) can be a CD27 ligand or a molecule (e.g., antibody) that binds a molecule on a cell such as a T cell, a tumor cell or a stromal cell. Pharmaceutical compositions comprising the CD27 agonists, and methods of using the CD27 agonists, are also provided.

Abstract: The present invention provides anti-TREM2 antibodies, formulations thereof, and methods of use thereof.

Abstract: The invention provides monoferrocenyl compounds of general formula I. The invention also provides substrates labelled with the compounds, functionalised derivatives of the compounds and methods of using the compounds, functionalised derivatives and labelled substrates in electrochemical assays.

Abstract: A passive dual modulating regulator that responds to a pressure differential between a hydrogen-side and an oxygen-side of one or more proton-exchange membrane (PEM) cells is provided. The passive dual modulating regulator includes a flexible diaphragm that is clamped along its periphery between hemispherical chambers. A bi-directional valve assembly extends through the flexible diaphragm and includes opposing valve plugs for selectively closing the output ports of the respective hemispherical chambers. Large or sustained pressure imbalances between the hydrogen-side and the oxygen-side of a hydrogen generation system are avoided without active control inputs of any kind, and consequently a rupture of the PEM is entirely avoided.

Abstract: A rotor core is provided that includes a rotor length defined along an axis of rotation and a plurality of separation channels. The plurality of separation channels having a channel length extending along the axis of rotation a distance that is less than the rotor length. A rotor assembly is also provided that includes such a rotor core removably disposed in an outer housing.

Abstract: The invention provides monoferrocenyl compounds of general formula I. The invention also provides substrates labelled with the compounds, functionalised derivatives of the compounds and methods of using the compounds, functionalised derivatives and labelled substrates in electrochemical assays.

Abstract: The invention provides monoferrocenyl compounds of general formula I. The invention also provides substrates labelled with the compounds, functionalised derivatives of the compounds and methods of using the compounds, functionalised derivatives and labelled substrates in electrochemical assays.

Abstract: A gear box for a reciprocating kneader. A primary rotational gear is attached to a gear box primary shaft and rotates in concert therewith. A secondary rotational gear is engaged with the primary rotation gear and rotates therewith. A secondary shaft is attached to the secondary rotational gear and rotates therewith. A primary oscillation gear is attached to the gear box primary shaft and rotates therewith. A secondary oscillation gear is rotationally engaged with the primary oscillation gear and rotates on the secondary shaft. An eccentric is coupled to the secondary oscillation gear and rotates in concert therewith. A yoke is engaged with the eccentric and oscillates on an axis perpendicular to the secondary shaft in response to the lobe. The gearbox secondary shaft moves along its axis in concert with yoke oscillation. A housing is pivotally attached to the yoke and pivotally attached to a casing at a casing.

Abstract: A rotor core is provided that includes a rotor length defined along an axis of rotation and a plurality of separation channels. The plurality of separation channels having a channel length extending along the axis of rotation a distance that is less than the rotor length. A rotor assembly is also provided that includes such a rotor core removably disposed in an outer housing.

Abstract: A system is provided that includes a controller in a control cabinet, a touch screen having a plurality of control icons, a controlled device, and a single safety sensor. The controlled device is a continuous flow centrifugation system. The controller prevents operation of the controlled device without simultaneous contact by a user of both the single safety sensor and a respective one of the plurality of control icons.

Abstract: A rotor core is provided that includes a rotor length defined along an axis of rotation and a plurality of separation channels. The plurality of separation channels having a channel length extending along the axis of rotation a distance that is less than the rotor length. A rotor assembly is also provided that includes such a rotor core removably disposed in an outer housing.

Abstract: A fluid handling system is provided that includes a controller, a plurality of valves, a pump, and an interface in communication with the controller. The valves can be operatively connected with a conduit to along a flow path. Each of the valves is controlled by the controller for selective movement between a first position and a second position. The first position closes the flow path, while the second position opens the flow path. The pump can be operatively connected with the conduit and the is controlled by the controller for selective pumping of fluid through the flow path. The interface allows selective definition of the flow path through the valves.

Abstract: A gear box for a reciprocating kneader. A primary rotational gear is attached to a gear box primary shaft and rotates in concert therewith. A secondary rotational gear is engaged with the primary rotation gear and rotates therewith. A secondary shaft is attached to the secondary rotational gear and rotates therewith. A primary oscillation gear is attached to the gear box primary shaft and rotates therewith. A secondary oscillation gear is rotationally engaged with the primary oscillation gear and rotates on the secondary shaft. An eccentric is coupled to the secondary oscillation gear and rotates in concert therewith. A yoke is engaged with the eccentric and oscillates on an axis perpendicular to the secondary shaft in response to the lobe. The gearbox secondary shaft moves along its axis in concert with yoke oscillation. A housing is pivotally attached to the yoke and pivotally attached to a casing at a casing.

Abstract: A sports training device attached to the shaft of a swinging sports apparatus, such as a baseball bat. The device includes a drag chute disposed between two rigid members, a support rod disposed between the two rigid members along the longitudinal axis of the chute, and a plurality of coupling elements connected to the support rod. Each coupling element includes an annular opening for positioning of the sports apparatus therethrough. One coupling element has a stationary component that secures the device to the sports apparatus and a rotating component that rotates 360° around the sports apparatus. As such, the entirety of the device, with exception to this stationary component, can substantially freely rotate 360° around the sports apparatus. Resistance during a swing can be adjusted by sliding the coupling mechanisms along the support rod to expose more or less of the chute.

Abstract: A sports training device attached to the shaft of a swinging sports apparatus, such as a baseball bat. The device includes a drag chute disposed between two rigid members, a support rod disposed between the two rigid members along the longitudinal axis of the chute, and a plurality of coupling elements connected to the support rod. Each coupling element includes an annular opening for positioning of the sports apparatus therethrough. One coupling element has a stationary component that secures the device to the sports apparatus and a rotating component that rotates 360° around the sports apparatus. As such, the entirety of the device, with exception to this stationary component, can substantially freely rotate 360° around the sports apparatus. Resistance during a swing can be adjusted by sliding the coupling mechanisms along the support rod to expose more or less of the chute.

Abstract: In some embodiments, an apparatus includes a control chain generation module is configured to receive, from a control database, a security guideline control to be implemented with respect to a hardware asset. The control chain generation module is configured to select, based on requirements to satisfy the security guideline and attributes of the hardware asset, a security implementation control. The control chain generation module is configured to select a control assessor to monitor the compliance of the hardware asset with the security guideline and is configured to define a control chain including the security guideline control, the security implementation control, and the control assessor. The control chain generation module is configured to send an instruction to apply the control chain to the hardware asset such that the control assessor monitors the hardware asset for compliance with the security guideline.

Abstract: The invention provides monoferrocenyl compounds of general formula I. The invention also provides substrates labelled with the compounds, functionalised derivatives of the compounds and methods of using the compounds, functionalised derivatives and labelled substrates in electrochemical assays.

Abstract: A fluid handling system is provided that includes a controller, a plurality of valves, a pump, and an interface in communication with the controller. The valves can be operatively connected with a conduit to along a flow path. Each of the valves is controlled by the controller for selective movement between a first position and a second position. The first position closes the flow path, while the second position opens the flow path. The pump can be operatively connected with the conduit and the is controlled by the controller for selective pumping of fluid through the flow path. The interface allows selective definition of the flow path through the valves.

Abstract: A method and apparatus for a reciprocating kneader. A primary rotational gear is attached to a gear box primary shaft and rotates in concert therewith and engages a secondary rotational gear. The primary rotational gear drive provides a primary source of rotation for a kneading screw and for the secondary gear as a secondary source of rotation. An adjustable eccentric is coupled to the secondary oscillation gear and rotates in concert therewith for reciprocation motion.

Abstract: A rotor core is provided that includes a rotor length defined along an axis of rotation and a plurality of separation channels. The plurality of separation channels having a channel length extending along the axis of rotation a distance that is less than the rotor length. A rotor assembly is also provided that includes such a rotor core removably disposed in an outer housing.