Patents by Inventor J. Martin Grisar

J. Martin Grisar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
    Patent number: 4367236
    Abstract: 4-Alkanoylimidazol-2-ones of the following general structure which are useful as cardiotonics in the treatment of cardiac failure ##STR1## wherein Q and T are each an oxygen atom or a divalent sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbonyl or benzoyl; R.sub.1 is hydrogen or lower alkyl; R.sub.2 is a lower aliphatic hydrocarbon radical, phenyl alkylene or heterocyclo alkylene; and the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 4, 1981
    Date of Patent: January 4, 1983
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: J. Martin Grisar, Richard A. Schnettler, Richard C. Dage
  • 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
    Patent number: 4329470
    Abstract: 2,3-Dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives having a 5-(4-phenyl-1-piperidinyl)methyl substituent, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate amine with a substituted 5-bromomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivative.
    Type: Grant
    Filed: May 4, 1981
    Date of Patent: May 11, 1982
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: J. Martin Grisar, Richard A. Schnettler, Richard C. Dage
  • 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
    Patent number: 4329471
    Abstract: 1,3-Dihydro-2H-imidazol-2-ones having 5-acyl and 4-(4-phenyl-1-piperidinyl)methyl substituents, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate substituted piperidine with a substituted 4-bromomethyl-1,3-dihydro-2H-imidazol-2-one.
    Type: Grant
    Filed: May 4, 1981
    Date of Patent: May 11, 1982
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: J. Martin Grisar, Richard A. Schnettler, Richard C. Dage
  • 2-(Diphenylalkylimino)piperidine-3-carboxanilides as inhibitors of gastrointestinal hypersecretion
    Patent number: 4281006
    Abstract: Compounds having the formula ##STR1## wherein A is a bond or C.sub.1-4 alkylene; R.sup.1, R.sup.2 and R.sup.3 are independently a halogen atom, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, CF.sub.3, SCF.sub.3 or OCF.sub.3 ; R.sup.4 is a hydrogen atom or C.sub.1-4 alkyl; and n, m and q are independently an integer from 0 to 3; and pharmaceutically acceptable acid addition salts thereof, are useful for the treatment of gastrointestinal hypersecretion.
    Type: Grant
    Filed: May 2, 1980
    Date of Patent: July 28, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, Norbert L. Wiech
  • 2-Hydroxy-5-(1-hydroxy-2-piperazinylethyl)-benzoic acid derivatives
    Patent number: 4255575
    Abstract: Derivatives of 2-hydroxy-5-(1-hydroxy-2-piperazinylethyl)benzoic acid are prepared which are useful for their blocking action on .alpha. and .beta.-adrenergic receptors. In addition, these compounds are useful as spasmolytic and antihypertensive agents.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: March 10, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton
  • Novel antihypertensive agent
    Patent number: 4221808
    Abstract: This invention is to the compound 5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]-2-me thoxybenzamide having the formula, ##STR1## pharmaceutically acceptable salts and individual optical isomers thereof, pharmaceutical compositions comprising as the active ingredient the compound of Formula 1 or salts or isomers thereof and the use of said compound, or salt or isomer thereof or pharmaceutical composition comprising same in the treatment of hypertension.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: September 9, 1980
    Assignee: Richardson-Merrell Inc.
    Inventor: J. Martin Grisar
  • 5-[2-[(2,3-Dihydro-1,4-benzodioxan-2-ylmethyl)amino]-1-hydrox yethyl]-2-hydroxybenzoic acid derivatives
    Patent number: 4206125
    Abstract: Derivatives of 5-[2-[(2,3-dihydro-1,4-benzodioxan-2-ylmethyl)amino]-1-hydroxyethyl]-2-hyd roxybenzoic acid are prepared which are useful for their blocking action on .alpha. and .beta.-adrenergic receptors. In addition, these compounds are useful as antihypertensive agents.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: June 3, 1980
    Assignee: Richardson-Merrell Inc.
    Inventor: J. Martin Grisar
  • 2-Hydro xy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]benzoic acid derivatives
    Patent number: 4200755
    Abstract: Derivatives of 2-hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]ben zoic acid are prepared which are useful for their blocking action on .alpha. and .beta.-adrenergic receptors. In addition, these compounds are useful for their spasmolytic and anti-hypertensive activity.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: April 29, 1980
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton
  • Substituted benzaldehyde hypolipidemic agents
    Patent number: 4187319
    Abstract: Substituted benzaldehydes of the following general structure are useful as hypolipidemic agents: ##STR1## wherein Y is selected from oxygen and divalent sulfur; R is selected from a straight or branched saturated hydrocarbon chain having from 10 to 20 carbon atoms and a straight or branched unsaturated hydrocarbon chain having from 10 to 20 carbon atoms and from 1 to 4 double bonds.
    Type: Grant
    Filed: June 2, 1977
    Date of Patent: February 5, 1980
    Assignee: Richardson-Merrell Inc.
    Inventors: Thomas R. Blohm, J. Martin Grisar, Roger A. Parker
  • Substituted benzaldehyde hypolipidemic agents
    Patent number: 4066788
    Abstract: Substituted benzaldehydes of the following general structure are useful as hypolipidemic agents: ##STR1## wherein Y is selected from oxygen and divalent sulfur; R is selected from a straight or branched saturated hydrocarbon chain having from 10 to 20 carbon atoms and a straight or branched unsaturated hydrocarbon chain having from 10 to 20 carbon atoms and from 1 to 4 double bonds.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: January 3, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Thomas R. Blohm, J. Martin Grisar, Roger Alan Parker
  • Lactamimide inhibitors of gastrointestinal hypersecretion
    Patent number: 4061746
    Abstract: A method of treating gastrointestinal hypersecretions which comprises administering substituted lactamimide derivatives.
    Type: Grant
    Filed: April 23, 1976
    Date of Patent: December 6, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: Thomas R. Blohm, J. Martin Grisar, Norbert L. Wiech
  • .alpha.-Alkylbenzyl lactamimides
    Patent number: 4055561
    Abstract: Novel derivatives of .alpha.-alkylbenzyl lactamimide are useful as anticoagulants.
    Type: Grant
    Filed: April 25, 1973
    Date of Patent: October 25, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton, Robert D. MacKenzie
  • N-(phenylether-substituted benzyl)alkanediamines
    Patent number: 4038412
    Abstract: Novel N-(substituted benzyl)alkanediamines are prepared which are useful for the prevention and inhibition of viral infections.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: July 26, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton
  • Process for preparing 2-azacycloalkylmethyl ketones
    Patent number: 3931155
    Abstract: A process for the preparation of 2-azacycloalkylmethyl ketones by chelating a methyl ketone with magnesium methyl carbonate and condensing the chelate with a 1-azacycloalkene in an atmosphere of carbon dioxide. The novel compounds described are useful anticoagulants.
    Type: Grant
    Filed: April 25, 1973
    Date of Patent: January 6, 1976
    Assignee: Richardson-Merrell Inc.
    Inventors: J. Martin Grisar, George P. Claxton