Patents by Inventor J. Matthew Velkey

J. Matthew Velkey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF DELIVERY OF NUCLEIC ACIDS TO A DEVELOPING EMBRYO
    Publication number: 20120047589
    Abstract: Methods to introduce genetic material, such as DNA, to embryos, are disclosed. In some embodiments, the method involves preparing the pregnant mother to receive the genetic material into a blood transport vessel which passes to the embryo, avoiding a maternal capillary bed and introducing the material under low pressure so as not to kill the pregnant animal. The effectiveness of the method is such that the nucleic acid has been expressed in all the cells of the embryo and in the postnatal mouse, including the primordial germ cells, thus making the nucleic acid germ line heritable.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 23, 2012
    Inventors: Theresa E. Gratsch, J. Matthew Velkey, Lisa S. D. Emmett, K. Sue O'Shea
  • Compositions and Methods for Generating Transgenic Animals
    Publication number: 20120030782
    Abstract: The present invention provides methods of altering gene expression of embryos to provide compositions and methods for efficient generation of transgenic animals. In particular, the present invention provides compositions and methods for generating germline transgenic animals by direct injection of nucleic acid molecules into animals.
    Type: Application
    Filed: October 4, 2011
    Publication date: February 2, 2012
    Applicant: The Regents of The University of Michigan
    Inventors: Lisa S. D. Emmett, Theresa Gratsch, K. Sue O'Shea, J. Matthew Velkey, Michael J. Welsh, William Wu
  • Compositions And Methods For Generating Transgenic Animals
    Publication number: 20100005535
    Abstract: The present invention provides methods of altering gene expression of embryos to provide compositions and methods for efficient generation of transgenic animals. In particular, the present invention provides compositions and methods for generating germ-line transgenic animals by direct injection of nucleic acid molecules into animals.
    Type: Application
    Filed: November 13, 2007
    Publication date: January 7, 2010
    Applicant: The Regents of The University of Michigan
    Inventors: Lisa S. D. Emmett, Theresa Gratsch, K. Sue O'Shea, J. Matthew Velkey, Michael J. Welsh, William Wu
  • METHOD OF DELIVERY OF NUCLEIC ACIDS TO A DEVELOPING EMBRYO
    Publication number: 20090235373
    Abstract: Methods to introduce genetic material, such as DNA, to embryos, are disclosed. In some embodiments, the method involves preparing the pregnant mother to receive the genetic material into a blood transport vessel which passes to the embryo, avoiding a maternal capillary bed and introducing the material under low pressure so as not to kill the pregnant animal. The effectiveness of the method is such that the nucleic acid has been expressed in all the cells of the embryo and in the postnatal mouse, including the primordial germ cells, thus making the nucleic acid germ line heritable.
    Type: Application
    Filed: October 10, 2008
    Publication date: September 17, 2009
    Applicant: The Regents of the University of Michigan
    Inventors: Theresa Gratsch, J. Matthew Velkey, Lisa S. D.Emmett, K. Sue O'Shea